{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,17]],"date-time":"2026-08-17T05:25:28Z","timestamp":1786944328432,"version":"build-2736575974"},"reference-count":41,"publisher":"Wiley","license":[{"start":{"date-parts":[[2026,8,16]],"date-time":"2026-08-16T00:00:00Z","timestamp":1786838400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2026,8,16]],"date-time":"2026-08-16T00:00:00Z","timestamp":1786838400000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82301149"],"award-info":[{"award-number":["82301149"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Small"],"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>Periodontal tissue regeneration in chronic periodontitis associated with diabetes mellitus (CPDM) remains challenging. Oxidative stress and host immune dysregulation driven by hyperglycemia further exacerbate periodontal tissue destruction. Therefore, strategies that reduce oxidative stress and remodel the periodontal immune microenvironment are critical for promoting periodontal regeneration in CPDM. However, the application of supramolecular hydrogels in CPDM therapy remains largely unexplored. In this study, a novel proanthocyanidin B2\u2010based adenosine supramolecular hydrogel\u2014guanosine\u2010adenosine\u2010proanthocyanidin B2 (GAOPCB2)\u2014was developed to enhance tissue regeneration in CPDM. Proanthocyanidin B2 exhibited potent reactive oxygen species (ROS)\u2010scavenging and anti\u2010inflammatory properties, promoting both HUVEC tube formation and stem cell osteogenic differentiation. The natural nucleoside adenosine further enhanced the osteogenic differentiation of stem cells. These findings indicate that the biomimetic GAOPCB2 supramolecular hydrogel possesses robust ROS\u2010scavenging, anti\u2010inflammatory, and osteogenic properties. Therefore, this multifunctional scaffold represents a promising platform for periodontal tissue regeneration in inflammatory environments. As demonstrated by both the in vitro and in vivo findings, the GAOPCB2 hydrogel is a promising therapeutic candidate for CPDM.<\/jats:p>","DOI":"10.1002\/smll.75230","type":"journal-article","created":{"date-parts":[[2026,8,17]],"date-time":"2026-08-17T05:02:50Z","timestamp":1786942970000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Proanthocyanidin B2\u2010Based Adenosine Supramolecular Hydrogel Promotes Tissue Regeneration in Diabetic Periodontitis"],"prefix":"10.1002","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-4371-1868","authenticated-orcid":false,"given":"Jiajia","family":"Qi","sequence":"first","affiliation":[{"name":"Department of Pediatric Dentistry Shanghai Key Laboratory of Craniomaxillofacial Development and Diseases Shanghai Stomatological Hospital &amp; School of Stomatology Fudan University  Shanghai 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