{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T19:59:14Z","timestamp":1790884754595,"version":"4.1.0"},"reference-count":42,"publisher":"Wiley","issue":"55","license":[{"start":{"date-parts":[[2026,8,20]],"date-time":"2026-08-20T00:00:00Z","timestamp":1787184000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,8,20]],"date-time":"2026-08-20T00:00:00Z","timestamp":1787184000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Small"],"published-print":{"date-parts":[[2026,10]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>\n                    Poly(\n                    <jats:italic>N<\/jats:italic>\n                    \u2010acryloyl glycine) (PNAG) bulk hydrogels are known to exhibit pH\u2010 and ion\u2010responsive behavior. In this study, PNAG hydrogel particles were prepared by droplet\u2010based microfluidics in combination with in situ photopolymerization. Rheological investigations led to the optimization of the PNAG gelation kinetics by the choice of photoinitiators, buffer media (pH 3, 7.4, or 9), and calcium ion (Ca\n                    <jats:sup>2+<\/jats:sup>\n                    ) concentrations (none or 5\u00a0wt.% CaCl\n                    <jats:sub>2<\/jats:sub>\n                    ). The microparticles demonstrated a strong swelling response, with a volume increase of over 5000\u00a0vol.% upon pH shifts. Rheology and multiple\u2010quantum nuclear magnetic resonance (MQ\u2010NMR) further revealed pronounced differences in network constraints and chain mobility between the investigated conditions. Via pH\u2010induced swelling, model biopharmaceuticals such as glutathione (GSH) were loaded into the particles by soaking, followed by compound entrapment through Ca\n                    <jats:sup>2+<\/jats:sup>\n                    \u2010induced network constriction, leading to high drug payloads &gt;20 wt.%. Drug release studies revealed an initial burst release, followed by a remarkable prolonged diffusion\u2010controlled release for about 2 weeks. As PNAG hydrogel particles demonstrated their potential for drug delivery, further studies could explore the tailoring of mesh sizes and broaden the spectrum of investigated biopharmaceuticals.\n                  <\/jats:p>","DOI":"10.1002\/smll.75268","type":"journal-article","created":{"date-parts":[[2026,8,20]],"date-time":"2026-08-20T09:40:05Z","timestamp":1787218805000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Dual\u2010Stimuli Responsive Poly(\n                    <i>N<\/i>\n                    \u2010acryloyl glycine) Microgels: Investigation of Network Structures and Application for Loading and Release of Biologics"],"prefix":"10.1002","volume":"22","author":[{"ORCID":"https:\/\/orcid.org\/0009-0002-8528-0437","authenticated-orcid":false,"given":"Yusuf","family":"Dursun","sequence":"first","affiliation":[{"name":"Institute of Pharmacy Martin\u2010Luther\u2010University Halle\u2010Wittenberg  Halle Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Burak","family":"Aydin","sequence":"additional","affiliation":[{"name":"Faculty of Pharmacy Bezmialem Vak\u0131f University  Istanbul Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5354-9775","authenticated-orcid":false,"given":"Bidit","family":"Lamsal","sequence":"additional","affiliation":[{"name":"Institute of Physics Martin\u2010Luther\u2010University Halle\u2010Wittenberg  Halle Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6853-3493","authenticated-orcid":false,"given":"Deniz","family":"Ceylan","sequence":"additional","affiliation":[{"name":"Faculty of Pharmacy Bezmialem Vak\u0131f University  Istanbul Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6246-4770","authenticated-orcid":false,"given":"Kay","family":"Saalw\u00e4chter","sequence":"additional","affiliation":[{"name":"Institute of Physics Martin\u2010Luther\u2010University Halle\u2010Wittenberg  Halle Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5531-9033","authenticated-orcid":false,"given":"Christian","family":"Wischke","sequence":"additional","affiliation":[{"name":"Institute of Pharmacy Martin\u2010Luther\u2010University Halle\u2010Wittenberg  Halle Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,8,20]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.1517\/17425247.2015.961420"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.1002\/jps.23018"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.1021\/jacs.7b00513"},{"key":"e_1_2_9_5_1","doi-asserted-by":"publisher","DOI":"10.1021\/acsami.6b00912"},{"key":"e_1_2_9_6_1","doi-asserted-by":"publisher","DOI":"10.1155\/2019\/8252036"},{"key":"e_1_2_9_7_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1201122109"},{"key":"e_1_2_9_8_1","unstructured":"Human Metabolome Database HMDB0001843 \u2013 N\u2010Acryloylglycine.https:\/\/hmdb.ca\/metabolites\/HMDB0001843(accessed 12. 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