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Although smart dressings with flexible sensing show promise, current systems remain limited to single\u2010signal detection without therapeutic efficacy. Herein, we propose a multimodal humidity\u2010temperature responsive dressing for real\u2010time monitoring and accelerated wound healing. The smart dressing (MSCP\/CS\/E\u2010MSCP, ECP) comprises three layers: a hydrophobic bottom MSCP layer of polylactic acid (PLA) nanofiber membranes loaded with MXene@sodium alginate (SA)@carboxylated polyaniline (C\u2010PANI) composite particles for humidity\u2010temperature sensing; a chitosan (CS) aerogel transport layer for exudate management; and a hydrophilic top E\u2010MSCP layer from ethanol\u2010treated MSCP. It achieves unidirectional water transport and manages the wound microenvironment, with exceptional sensitivity (\u2212 99.32%, \u22654.19\u00b0C\n                    <jats:sup>\u22121<\/jats:sup>\n                    ), resolution (1%RH, 0.1\u00b0C), and response range (11%\u201398%RH, 33\u00b0C\u201343\u00b0C) for real\u2010time monitoring. Using a standard acute full\u2010thickness wound model, in vitro and in vivo assays show that the ECP accelerates healing by promoting cell migration, collagen deposition, angiogenesis, and immunomodulation. Real\u2010time data are processed by a convolutional neural network (CNN) and wirelessly sent to a smartphone, enabling wound status visualization and healing prediction. Therefore, this dressing provides a potential strategy for real\u2010time monitoring and offers insights into chronic wound microenvironment regulation.\n                  <\/jats:p>","DOI":"10.1002\/smll.75275","type":"journal-article","created":{"date-parts":[[2026,8,18]],"date-time":"2026-08-18T09:08:00Z","timestamp":1787044080000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["A Smart Dressing With Multimodal Humidity\u2010Temperature Sensing for Real\u2010Time Monitoring and Accelerated Wound Healing"],"prefix":"10.1002","volume":"22","author":[{"ORCID":"https:\/\/orcid.org\/0009-0006-1205-2504","authenticated-orcid":false,"given":"Huijie","family":"Zhang","sequence":"first","affiliation":[{"name":"Beijing Key Laboratory of Clothing Materials R &amp; D and Assessment Beijing Engineering Research Center of Textile Nanofiber School of Materials Design &amp; Engineering Beijing Institute of Fashion Technology  Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jia","family":"Guo","sequence":"additional","affiliation":[{"name":"Beijing Institute of Hepatology Beijing Youan Hospital Capital Medical University  Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Buxin","family":"Kou","sequence":"additional","affiliation":[{"name":"Beijing Institute of Hepatology Beijing Youan Hospital Capital Medical University  Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mengyin","family":"Chai","sequence":"additional","affiliation":[{"name":"Beijing Institute of Hepatology Beijing Youan Hospital Capital Medical University  Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shuang","family":"Dou","sequence":"additional","affiliation":[{"name":"Beijing Institute of Hepatology Beijing Youan Hospital Capital Medical University  Beijing 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Materials Design &amp; Engineering Beijing Institute of Fashion Technology  Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiuqin","family":"Zhang","sequence":"additional","affiliation":[{"name":"Beijing Key Laboratory of Clothing Materials R &amp; D and Assessment Beijing Engineering Research Center of Textile Nanofiber School of Materials Design &amp; Engineering Beijing Institute of Fashion Technology  Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4957-9987","authenticated-orcid":false,"given":"Bin","family":"Wang","sequence":"additional","affiliation":[{"name":"Beijing Key Laboratory of Clothing Materials R &amp; D and Assessment Beijing Engineering Research Center of Textile Nanofiber School of Materials Design &amp; Engineering Beijing Institute of Fashion Technology  Beijing 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