{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,23]],"date-time":"2026-10-23T02:39:12Z","timestamp":1792723152480,"version":"4.5.0"},"reference-count":62,"publisher":"Wiley","issue":"59","license":[{"start":{"date-parts":[[2026,8,17]],"date-time":"2026-08-17T00:00:00Z","timestamp":1786924800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2026,8,17]],"date-time":"2026-08-17T00:00:00Z","timestamp":1786924800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["12435001"],"award-info":[{"award-number":["12435001"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Small"],"published-print":{"date-parts":[[2026,10]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>\n                    Chronic bacterial infections pose a therapeutic challenge in eliminating bacteria while suppressing inflammation. Conventional antibiotics are often limited by drug resistance and poor biofilm penetration, contributing to a global health threat of antibiotic misuse. Reactive oxygen species (ROS) modulation offers a promising alternative, yet requires precise balance: insufficient ROS compromises antibacterial efficacy, but excess exacerbates inflammation. Here, we present a bidirectional ROS\u2010regulation strategy for programmed antibacterial and anti\u2010inflammatory therapy using Au\u2010edged cuprous oxide (Cu\n                    <jats:sub>2<\/jats:sub>\n                    O)\u00a0nanocubes on MXene (Au\u2010Cu\n                    <jats:sub>2<\/jats:sub>\n                    O\/MXene). Under near\u2010infrared (NIR) irradiation, this nanocomposite induces moderate ROS, eliminating &gt;99% of planktonic bacteria and &gt;97% of mature biofilms. After cessation of NIR irradiation, the nanocomposite itself switches to scavenge the residual excessive ROS in the inflammatory microenvironment, which alleviates oxidative stress. Our skin wound infection model further demonstrates that Au\u2010Cu\n                    <jats:sub>2<\/jats:sub>\n                    O\/MXene markedly reduces bacterial burden, suppresses inflammatory responses, and accelerates wound closure. Theoretical computations reveal that Au\u2010capping weakens O\n                    <jats:sub>2<\/jats:sub>\n                    adsorption through weak O 2p\u2010Au 5d orbital hybridization and hinders photogenerated electron transfer with high work function, suppressing ROS overproduction; it also lowers the free energy barrier for H\n                    <jats:sub>2<\/jats:sub>\n                    O\/O\n                    <jats:sub>2<\/jats:sub>\n                    desorption, promoting ROS decomposition. This work offers an effective antibiotic\u2010free immunomodulation strategy for programmed biofilm eradication, infected wound repair, and inflammation suppression via context\u2010dependent ROS modulation.\n                  <\/jats:p>","DOI":"10.1002\/smll.75279","type":"journal-article","created":{"date-parts":[[2026,8,17]],"date-time":"2026-08-17T07:10:52Z","timestamp":1786950652000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Bidirectional ROS Modulation for Programmed Anti\u2010Infective and Anti\u2010Inflammatory Therapy With Au\u2010Cu\n                    <sub>2<\/sub>\n                    O\/MXene Nanocomposite"],"prefix":"10.1002","volume":"22","author":[{"given":"Min","family":"Zhang","sequence":"first","affiliation":[{"name":"School of Physics State Key Laboratory of Bioreactor Engineering East China University of Science and Technology  Shanghai 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Technology  Shanghai China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3641-2803","authenticated-orcid":false,"given":"Ying","family":"Hou","sequence":"additional","affiliation":[{"name":"School of Physics State Key Laboratory of Bioreactor Engineering East China University of Science and Technology  Shanghai China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Junjie","family":"Mou","sequence":"additional","affiliation":[{"name":"School of Physics State Key Laboratory of Bioreactor Engineering East China University of Science and Technology  Shanghai China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Haoming","family":"Xia","sequence":"additional","affiliation":[{"name":"School of Physics State Key Laboratory of Bioreactor Engineering East China University of Science and Technology  Shanghai 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and Technology  Shanghai China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0007-4556-1281","authenticated-orcid":false,"given":"Hui","family":"He","sequence":"additional","affiliation":[{"name":"Fashion Design College of Lstituto Marangoni (School of International Education) Zhejiang Sci\u2010Tech University  Zhejiang, Linping China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2746-8055","authenticated-orcid":false,"given":"Chunhua","family":"Zeng","sequence":"additional","affiliation":[{"name":"Faculty of Science Kunming University of Science and Technology  Yunan, Kunming China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yingying","family":"Huang","sequence":"additional","affiliation":[{"name":"School of Physics State Key Laboratory of Bioreactor Engineering East China University of Science and Technology  Shanghai 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