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Here, we report an innovative pH\u2010responsive catalytic microneedle system (GZIF@Fe MN) designed to combat bacterial infections by disrupting bacterial redox homeostasis through a cascade Fenton reaction, generating highly reactive hydroxyl radicals (\u00b7OH). The system utilizes a Schiff base reaction between oxidized hyaluronic acid and carboxymethyl chitosan to construct a pH\u2010sensitive microneedle matrix capable of transdermal and delivery of embedded glucose oxidase (GOx) and Fe\n                    <jats:sup>3+<\/jats:sup>\n                    \u2010modified metal\u2010organic framework ZIF\u20108 (ZIF@Fe) for deep tissue release. The catalytic product of GOx, gluconic acid, creates an acidic microenvironment that facilitates the degradation of ZIF@Fe, leading to the rapid release of Fe\n                    <jats:sup>3+<\/jats:sup>\n                    . Simultaneously, GOx catalyzes glucose metabolism to generate H\n                    <jats:sub>2<\/jats:sub>\n                    O\n                    <jats:sub>2<\/jats:sub>\n                    , which drives continuous production of \u00b7OH, enhancing the bactericidal effect. In vitro studies demonstrate that the cascade reaction achieves nearly 99% bactericidal efficacy against\n                    <jats:italic>S. aureus<\/jats:italic>\n                    and\n                    <jats:italic>E. coli<\/jats:italic>\n                    . In vivo experiments reveal that GZIF@Fe MN promotes macrophage polarization toward the anti\u2010inflammatory M2 phenotype, thereby reducing excessive inflammation and facilitating tissue regeneration, with wound closure exceeding 90%. Overall, the GZIF@Fe MN system provides an effective antibacterial wound therapy strategy and offers new insights into the development of next\u2010generation antibacterial biomaterials.\n                  <\/jats:p>","DOI":"10.1002\/smll.75291","type":"journal-article","created":{"date-parts":[[2026,8,18]],"date-time":"2026-08-18T09:34:26Z","timestamp":1787045666000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Environmentally Responsive Catalytic Microneedles Enable Cascade Fenton Reaction for Antibacterial Therapy and Accelerated Infected Wound Healing"],"prefix":"10.1002","volume":"22","author":[{"given":"Yongjie","family":"Cai","sequence":"first","affiliation":[{"name":"Institute of Biomedical Engineering College of Medicine Southwest Jiaotong University  Chengdu 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