{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,18]],"date-time":"2026-08-18T10:30:23Z","timestamp":1787049023714,"version":"build-2736575974"},"reference-count":65,"publisher":"Wiley","license":[{"start":{"date-parts":[[2026,8,18]],"date-time":"2026-08-18T00:00:00Z","timestamp":1787011200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,8,18]],"date-time":"2026-08-18T00:00:00Z","timestamp":1787011200000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Small"],"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>Light\u2013mediated assembly of catalytic agents furnishes powerful means for spatiotemporal control of chemical reactions. Here, we demonstrate photo\u2010switched hierarchical assembly of catalytic amyloid fibrils, through mixing an amphiphilic cross\u2010\u00df peptide with a merocyanine photo\u2010switch. The peptide monomers, comprising phenylalanine\u2010lysine repeats, do not self\u2010assemble in water because of the electrostatic repulsion between the positively charged lysine side chains; however, upon light\u2010induced merocyanine\u2010spiropyran transformation, amyloid fibrils were formed. Interestingly, increasing the mole ratio between the merocyanine photo\u2010switch and the peptide gave rise to a remarkable assembly of aligned elongated fibrils. The process was fully reversible as light turn\u2010off resulted in fibril disintegration. Notably, the photoinduced amyloid fibrils catalyzed hydrolysis of \u03b2\u2010lactam antibiotics, offering a platform for light\u2010mediated degradation of antibiotic pollutants in water. Microscopic and spectroscopic experiments reveal that the photoinduced transient catalytic amyloids were likely formed through \u03c0\u2013\u03c0 interactions between the spiropyran moieties and the aromatic residues of the phenylalanines, while electrostatic interactions between the negative sulfonates and lysine sidechains on the fibrils\u2019 surface were responsible for the macroscale alignment. The amyloid\u2010merocyanine system represents a new concept for light\u2010regulated assembly of catalytic amyloids, which may have also played a role in prebiotic evolution processes.<\/jats:p>","DOI":"10.1002\/smll.75302","type":"journal-article","created":{"date-parts":[[2026,8,18]],"date-time":"2026-08-18T10:16:24Z","timestamp":1787048184000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Photo\u2010Switched Catalytic Amyloids"],"prefix":"10.1002","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-4965-8850","authenticated-orcid":false,"given":"Shubhra Kanti","family":"Bhaumik","sequence":"first","affiliation":[{"name":"Department of Chemistry Ben\u2010Gurion University of the Negev  Beer Sheva Israel"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0001-3095-2657","authenticated-orcid":false,"given":"Sisira 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