{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,27]],"date-time":"2026-08-27T14:39:46Z","timestamp":1787841586653,"version":"build-2784847793"},"reference-count":41,"publisher":"Wiley","license":[{"start":{"date-parts":[[2026,8,27]],"date-time":"2026-08-27T00:00:00Z","timestamp":1787788800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2026,8,27]],"date-time":"2026-08-27T00:00:00Z","timestamp":1787788800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/501100012166","name":"National Key Research and Development Program of China","doi-asserted-by":"publisher","award":["2024YFC2311503"],"award-info":[{"award-number":["2024YFC2311503"]}],"id":[{"id":"10.13039\/501100012166","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82322042"],"award-info":[{"award-number":["82322042"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82102444"],"award-info":[{"award-number":["82102444"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82272248"],"award-info":[{"award-number":["82272248"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Small"],"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>Effective management of diabetic wound healing remains challenging due to the complex wound microenvironment, characterized by persistent infections and inflammation, as well as obstacles in tissue repair, including impaired extracellular matrix (ECM) remodeling and re\u2010epithelialization. Herein, we propose a sequential integrating microenvironment regulation and re\u2010epithelialization promotion (SIMREP) strategy based on zinc\u2010doped glycyrrhizinate carbon dots loaded with aggregation\u2010induced emission luminogens (AIEgens), namely TTPy\u2010Zn@GCDs for accelerated diabetic wound healing. TTPy\u2010Zn@GCDs effectively inhibit bacterial infection through AIEgen\u2010based photodynamic therapy and promote the M2\u2010phenotype polarization of macrophages by eliminating reactive oxygen species. Remarkably, TTPy\u2010Zn@GCDs not only present a superior ECM remodeling ability by suppressing the overexpression of matrix metalloproteinase (MMP)\u20109 in diabetic wounds, but also promote keratinocyte migration and accelerate the re\u2010epithelialization process by activating the hypoxia\u2010inducible factor\u20101\u03b1 (HIF\u20101\u03b1) signaling pathway. Together, the SIMREP strategy offers a promising approach for accelerating the healing process of infected diabetic wounds.<\/jats:p>","DOI":"10.1002\/smll.75314","type":"journal-article","created":{"date-parts":[[2026,8,27]],"date-time":"2026-08-27T14:04:31Z","timestamp":1787839471000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Sequential Integration of Microenvironment Regulation Utilizing Aggregation\u2010Induced Emission Luminogen\u2010Based Carbon Dots for Diabetic Wound Treatment"],"prefix":"10.1002","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-5016-700X","authenticated-orcid":false,"given":"Judun","family":"Zheng","sequence":"first","affiliation":[{"name":"Molecular Diagnosis and Treatment Center For Infectious Diseases Dermatology Hospital Southern Medical University  Guangzhou P. R. 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