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Herein, we have successfully synthesized dual\u2010functional nanoconfined metal\u2013organic frameworks encapsulating Pt\u2010A\u2010COOH complexes (Pt@UiO\u201067 MOFs) as electrochemiluminescence emitters and co\u2010reaction accelerators by a ligand\u2010similarity\u2010driven doping strategy. The dual\u2010functional Pt@UiO\u201067 MOFs unlocked aggregation\u2010induced electrochemiluminescence and expedited interfacial reaction kinetics by spatial nanoconfinement, the electrochemiluminescence efficiency of which was\n                    <jats:italic>ca<\/jats:italic>\n                    . 5.4\u2010fold higher than that of the Pt\u2010A\u2010COOH as co\u2010reactant to catalyze the decomposition of S\n                    <jats:sub>2<\/jats:sub>\n                    O\n                    <jats:sub>8<\/jats:sub>\n                    <jats:sup>2\u2212<\/jats:sup>\n                    . Density functional theory calculations and electrochemical electron paramagnetic resonance measurements indicated that the nanoconfinement structure reduced the activation energy barrier for the reduction of S\n                    <jats:sub>2<\/jats:sub>\n                    O\n                    <jats:sub>8<\/jats:sub>\n                    <jats:sup>2\u2212<\/jats:sup>\n                    , thereby optimizing the kinetics of SO\n                    <jats:sub>4<\/jats:sub>\n                    <jats:sup>\u2022\u2212<\/jats:sup>\n                    (0.92 eV) and OH\n                    <jats:sup>\u2022<\/jats:sup>\n                    (0.63 eV) radical generation. Based on the Pt@UiO\u201067 MOFs and DNAzyme motor, the ultrasensitive biosensor has been successfully constructed and had wide linear range (from \u223c10 aM to \u223c10 nM) and an ultralow detection limit of \u223c4.1 aM. In the preliminary proof\u2010of\u2010concept evaluation using acute kidney injury clinical samples, the assay results had excellent concordance with those of quantitative reverse transcription polymerase chain reaction. This work provides a paradigm integrating supramolecular engineering with DNA nanotechnology, which paves the way for sensitive biodetection and preliminary clinical screening.\n                  <\/jats:p>","DOI":"10.1002\/smll.75344","type":"journal-article","created":{"date-parts":[[2026,8,21]],"date-time":"2026-08-21T09:51:27Z","timestamp":1787305887000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Dual\u2010Functional Nanoconfined Metal\u2010Organic Frameworks with Aggregation\u2010Induced Electrochemiluminescence Coupled with DNAzyme Motor for Ultrasensitive miRNA\u201021 Biosensing"],"prefix":"10.1002","volume":"22","author":[{"given":"Wanzhen","family":"Chen","sequence":"first","affiliation":[{"name":"School of Chemistry and Chemical Engineering Key Lab of Fuel Cell Technology of Guangdong Province South China University of Technology  Guangzhou China"},{"name":"State Key Laboratory of Organ Failure 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