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For this purpose, a multifunctional borate bioactive glass (B\u2010BG) with dynamic pH was designed. In vitro studies indicated, within 2 days, a significant increase in pH up to \u223c8.3 was generated to inhibit tumor cells. In the meantime, the increase of surrounding pH generated the formation of apatite\u2010like minerals on the glass surface due to higher supersaturation with respect to hydroxyapatite, thus slow down the degradation rate of B\u2010BG to generate the second stage, a moderate pH range between 7.5 and 8.0, thus increasing the expression of angiogenic genes in HUVECs at 2 days to 2 weeks, and then osteogenic genes in hADSCs after 2 weeks. Such results were further confirmed by implanting B\u2010BG in a mouse CDX osteosarcoma model, a rabbit tumor metastatic model, and a rabbit femoral condyle defect model. The intelligence of such composition indicates the ability to spontaneously meet the surrounding environment respectively tumor inhibition and bone formation. In summary, multifunctional borate bioactive glass (B\u2010BG) may provide a promising strategy for the treatment of bone tumors and the repair of bone defects.<\/jats:p>","DOI":"10.1002\/smll.75378","type":"journal-article","created":{"date-parts":[[2026,9,3]],"date-time":"2026-09-03T10:59:38Z","timestamp":1788433178000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Bifunctional Borate Bioactive Glass (B\u2010BG) Spontaneously Inhibits Bone Tumor and Time\u2010Sequentially Promotes Bone Regeneration"],"prefix":"10.1002","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-3330-2895","authenticated-orcid":false,"given":"Renxian","family":"Wang","sequence":"first","affiliation":[{"name":"JST sarcopenia Research Centre National Center for Orthopaedics Beijing Research Institute of Traumatology and Orthopaedics Beijing Jishuitan Hospital Capital Medical University  Beijing 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https:\/\/www.nccn.org\/patients\/guidelines\/content\/PDF\/bone\u2010patient.pdf."},{"key":"e_1_2_10_3_1","doi-asserted-by":"crossref","first-page":"77","DOI":"10.1038\/s41572-022-00409-y","article-title":"Osteosarcoma","volume":"8","author":"Beird H. 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A.","year":"2016","journal-title":"Biomaterials"},{"key":"e_1_2_10_29_1","doi-asserted-by":"crossref","first-page":"8785","DOI":"10.1007\/s10853-016-0563-7","article-title":"Angiogenic Potential of Boron\u2010Containing Bioactive Glasses: In Vitro Study","volume":"52","author":"Balasubramanian P.","year":"2017","journal-title":"Journal of Materials Science"},{"issue":"3","key":"e_1_2_10_30_1","doi-asserted-by":"crossref","first-page":"855","DOI":"10.1016\/j.jeurceramsoc.2017.11.001","article-title":"Boron\u2010Containing Bioactive Glasses in Bone and Soft Tissue Engineering","volume":"38","author":"Balasubramanian P.","year":"2018","journal-title":"Journal of the European Ceramic Society"},{"issue":"3","key":"e_1_2_10_31_1","doi-asserted-by":"crossref","first-page":"1186","DOI":"10.1002\/jbm.b.33930","article-title":"Development of a Novel Bioactive Glass Suitable for Osteosarcoma\u2010Related Bone Grafts","volume":"106","author":"Rahimnejad Yazdi A.","year":"2018","journal-title":"Journal of Biomedical Materials Research Part B: Applied Biomaterials"},{"issue":"1","key":"e_1_2_10_32_1","doi-asserted-by":"crossref","first-page":"303","DOI":"10.1111\/j.1551-2916.2006.01358.x","article-title":"In Vitro Bioactive Characteristics of Borate\u2010Based Glasses With Controllable Degradation Behavior","volume":"90","author":"Yao A. 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