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Dehiscence, inflammation, and scarring can complicate outcomes with conventional wound approximation and closure devices. To overcome these challenges, we leveraged the antibacterial properties of silver ion\u2010exchanged nanostructured zeolites (AgNZeo) embedded within silk fibroin\u2010based laser\u2010activated sealant (LASE) films containing silver nanoprisms (AgNPr). AgNPr enabled efficient absorption of near\u2010infrared (NIR) light, resulting in photothermal conversion of this energy and sealing of full\u2010thickness incisional wounds in mice. AgNZeo\u2010LASE films showed excellent antibacterial activity against methicillin\u2010resistant\n                    <jats:italic>Staphylococcus aureus<\/jats:italic>\n                    (MRSA) bacteria in in vitro antimicrobial susceptibility assays. AgNZeo\u2010LASE films, upon laser irradiation, were able to seal incisional wounds in diabetic and obese mice, and protected against surgical site MRSA infections, demonstrating performance comparable to commercial antibacterial sutures. Immunohistochemical analyses indicated similar neutrophil recruitment and macrophage polarization with AgNZeo\u2010LASE compared to suture controls. Our results support the use of silver ion\u2010loaded nanozeolites as effective antibacterial agents and suggest that AgNZeo\u2010LASE films may be useful for topical infection control.\n                  <\/jats:p>","DOI":"10.1002\/smll.75380","type":"journal-article","created":{"date-parts":[[2026,9,4]],"date-time":"2026-09-04T03:28:31Z","timestamp":1788492511000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Silver Nanozeolite\u2010Loaded Skin Sealants Combat Surgical Site Infection in Diabetic and Obese Mice"],"prefix":"10.1002","volume":"22","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-0372-7494","authenticated-orcid":false,"given":"Shubham","family":"Pallod","sequence":"first","affiliation":[{"name":"Center for Biomaterials Innovation and Translation Biodesign Institute Arizona State University  Tempe Arizona USA"},{"name":"Biological Design Graduate Program School for Engineering of Matter Transport, and Energy Arizona State University  Tempe Arizona USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9295-3022","authenticated-orcid":false,"given":"Yannik A.","family":"Haller","sequence":"additional","affiliation":[{"name":"Center for Bioelectronics and Biosensors Biodesign Institute Arizona State University  Tempe Arizona USA"},{"name":"School of Life Sciences Arizona State University  Tempe Arizona USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"D'Kiehl","family":"Cole\u2010Cash","sequence":"additional","affiliation":[{"name":"Center for Biomaterials Innovation and Translation Biodesign Institute Arizona State University  Tempe Arizona USA"},{"name":"Biological Design Graduate Program School for Engineering of Matter Transport, and Energy Arizona State University  Tempe Arizona 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