{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,25]],"date-time":"2026-08-25T13:23:24Z","timestamp":1787664204955,"version":"build-2736575974"},"reference-count":50,"publisher":"Wiley","license":[{"start":{"date-parts":[[2026,8,25]],"date-time":"2026-08-25T00:00:00Z","timestamp":1787616000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2026,8,25]],"date-time":"2026-08-25T00:00:00Z","timestamp":1787616000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["22478363"],"award-info":[{"award-number":["22478363"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["22404043"],"award-info":[{"award-number":["22404043"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Small"],"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>\n                    The regulation of death programs is central to malignant behaviors and immune evasion of tumor cells and represents a promising therapeutic target in cancer therapy. The main challenge lies in how to utilize associated signaling among different cell death processes for amplifying antitumor effect. This study proposes an effective \u201csignal crosstalk\u201d strategy driven by the disruption of intracellular messenger homeostasis, which triggers concurrent death pathways and immune activation to suppress metastasis. The CaS@ZIF\u20108 nanomessengers are engineered to augment intracellular Ca\n                    <jats:sup>2+<\/jats:sup>\n                    , Zn\n                    <jats:sup>2+,<\/jats:sup>\n                    and H\n                    <jats:sub>2<\/jats:sub>\n                    S concentrations. Through molecular interlink of the downstream signaling network, a \u201cnecroptosis\u2010anoikis\u2010apoptosis\u201d crosstalk pattern is elicited to realize efficient immunogenic cell death (ICD) effect. The sufficient ICD effect reverses the immunosuppressive microenvironment to facilitate antigen presentation and the intratumoral infiltration of immune cells. Furthermore, the crosstalk pattern effectively downregulates adhesion\u2010 and metastasis\u2010associated factors to prevent tumor cells re\u2010implantation. The strategy thereby fosters adaptive antitumor immunity and reinstates immune surveillance against tumor metastasis. Our findings elucidate the mechanism of nanomessenger\u2010mediated multithreading death program and provide a crucial basis for targeted intervention of cell death patterns to treat diseases.\n                  <\/jats:p>","DOI":"10.1002\/smll.75440","type":"journal-article","created":{"date-parts":[[2026,8,25]],"date-time":"2026-08-25T13:03:11Z","timestamp":1787662991000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Nanomessenger\u2010Mediated Signal Crosstalk Encodes Multithreading Death Program Against Tumor Metastasis"],"prefix":"10.1002","author":[{"given":"Mengyang","family":"Wang","sequence":"first","affiliation":[{"name":"School of Life Sciences Anhui Medical University  Hefei Anhui China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yijing","family":"Zhang","sequence":"additional","affiliation":[{"name":"School of Life Sciences Anhui Medical University  Hefei Anhui 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