{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,27]],"date-time":"2026-08-27T09:17:20Z","timestamp":1787822240485,"version":"build-2784847793"},"reference-count":31,"publisher":"Wiley","license":[{"start":{"date-parts":[[2026,8,27]],"date-time":"2026-08-27T00:00:00Z","timestamp":1787788800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2026,8,27]],"date-time":"2026-08-27T00:00:00Z","timestamp":1787788800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Small"],"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>Environmental polyethylene terephthalate micro\u2010 and nanoplastics (PET\u2010MNPs) are biologically accessible contaminants, but their effects on clear cell renal cell carcinoma (ccRCC) progression remain unclear. Using 786\u2010O and CAKI\u20101 cells and subcutaneous and orthotopic xenograft models, we found that PET\u2010MNP exposure enhanced malignant phenotypes and tumor growth, accompanied by increased intracellular and mitochondrial ROS. Mitochondrial superoxide accumulation was associated with membrane depolarization, reduced ATP levels, ultrastructural abnormalities, and decreased SOD2 expression and Mn\u2010SOD activity. Mechanistically, PET\u2010MNP exposure increased AKT and inhibitory GSK3\u03b2 Ser9 phosphorylation, reduced degradation\u2010associated phosphorylation and ubiquitination of \u03b2\u2010catenin, and enhanced \u03b2\u2010catenin stability, nuclear accumulation, and transcriptional activity. Time\u2010course analysis indicated that AKT activation preceded prominent GSK3\u03b2 and \u03b2\u2010catenin changes. MitoTEMPO, pharmacological AKT or \u03b2\u2010catenin inhibition, AKT knockdown, \u03b2\u2010catenin\u2010S33Y rescue, and GSK3\u03b2\u2010S9A experiments further supported the functional involvement of mitochondrial ROS\u2010associated AKT\/GSK3\u03b2\/\u03b2\u2010catenin regulation. ChIP\u2010qPCR and RT\u2010qPCR showed increased \u03b2\u2010catenin recruitment to MYC and CCND1 regulatory regions and enhanced transcription. These findings support a role for mitochondrial ROS\u2010associated AKT\/GSK3\u03b2\/\u03b2\u2010catenin regulation in PET\u2010MNP\u2010promoted ccRCC progression.<\/jats:p>","DOI":"10.1002\/smll.75494","type":"journal-article","created":{"date-parts":[[2026,8,27]],"date-time":"2026-08-27T08:18:59Z","timestamp":1787818739000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Environmental Polyethylene Terephthalate Micro\u2010 and Nanoplastics Promote Clear Cell Renal Cell Carcinoma Progression Through Mitochondrial ROS\u2010Associated AKT\/GSK3\u03b2\/\u03b2\u2010Catenin Signaling"],"prefix":"10.1002","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-8916-9237","authenticated-orcid":false,"given":"Xiao\u2010Hui","family":"Wu","sequence":"first","affiliation":[{"name":"Department of Urology Urology Research Institute, the First Affiliated Hospital Fujian Medical University  Fuzhou Fujian China"},{"name":"Department 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