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Here, we investigate the loading of various reporter dyes into non\u2010porous and porous cerasomes, a hybrid nanoscopic biomimetic material, and how pH\u2010dependent supramolecular adenosine 5\u2032\u2010triphosphate (ATP) binding at the polyaminic gatekeepers anchored at the cerasomes\u2019 pore outlets is influencing pH gating. Such organic\u2010inorganic nanovesicles are composed of a siliceous crosslinked lipid bilayer enclosing a liquid\u2010filled void. Preparation of porous cerasomes was achieved by inserting poloxamer block\u2010co\u2010polymers into the membrane during synthesis. To our knowledge, this is the first example of porous cerasomes and their use in gating applications. We successfully encapsulated or loaded reporter molecules into these objects, with the loading preference depending on their charge, hydrophobicity and chemical structure. The addition of molecular gates, responding to pH and\/or anions such as ATP, allowed the pores\u2019 controlled opening, thereby modulating proton influx, which can be read out via fluorescence response. Considering the corresponding pH sensitivity, dye loaded cerasomes are promising reagents for detecting ATP in relevant concentrations (0.02 to 1000\u00a0\u00b5\n                    <jats:sc>M<\/jats:sc>\n                    ) with distinctly faster fluorescence responses as compared to standard gated mesoporous materials.\n                  <\/jats:p>","DOI":"10.1002\/smll.75507","type":"journal-article","created":{"date-parts":[[2026,8,31]],"date-time":"2026-08-31T07:30:36Z","timestamp":1788161436000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Fluorescence Sensing of Anions Like Adenosine 5\u02b9\u2010Triphosphate With pH\u2010Gated Porous Dye\u2010Loaded Cerasomes"],"prefix":"10.1002","author":[{"ORCID":"https:\/\/orcid.org\/0009-0005-2455-2541","authenticated-orcid":false,"given":"Romane","family":"Vinot","sequence":"first","affiliation":[{"name":"Chemical and Optical Sensing Division Bundesanstalt 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