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However, current methods for rapidly characterizing local tissue biomechanical properties remain limited. In this study, we present a novel MEMS\u2010integrated piezoelectric sensor\u2010based medical microtool (IPS\u2010MMT), this device can map the elastic modulus of local tissues in real time and at the sub\u2010millimeter scale, enabling rapid and localized measurements under controlled in vitro conditions. Our device features the integration of a 100\u00a0\u00b5m\u2011thick piezoelectric sensor onto a 300\u00a0\u00b5m\u2011diameter tungsten tip fabricated via a scalable electrochemical etching platform. This configuration transduces minute tissue deformations into quantifiable electrical signals with a spatial resolution of \u223c15\u00a0\u00b5m and a response time under 10\u00a0ms. In ex vivo studies on rat organs and human hepatocellular carcinoma specimens, the IPS\u2010MMT resolved distinct tissue\u2010stiffness differences among normal, peritumoral, and cancerous regions. Independent rheological measurements on six rat organ tissues showed a mean relative agreement of 91.83% with the IPS\u2010MMT measurements, supporting tissue elastic modulus as a promising biomechanical biomarker for tissue differentiation and highlighting the potential of biomechanics\u2010guided precision ablation.<\/jats:p>","DOI":"10.1002\/smll.75511","type":"journal-article","created":{"date-parts":[[2026,8,27]],"date-time":"2026-08-27T10:28:59Z","timestamp":1787826539000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["A Piezoelectric Microtool for In Vitro Elastic Modulus Measurement and Hepatocellular Carcinoma Boundary Identification"],"prefix":"10.1002","author":[{"given":"Xiaojun","family":"Zhang","sequence":"first","affiliation":[{"name":"School of Mechanical Engineering Qilu University of Technology (Shandong Academy of Sciences)  Jinan China"},{"name":"Shandong Institute of Mechanical Design and 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