{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,31]],"date-time":"2026-08-31T06:15:19Z","timestamp":1788156919496,"version":"build-2803163510"},"reference-count":42,"publisher":"Wiley","license":[{"start":{"date-parts":[[2026,8,30]],"date-time":"2026-08-30T00:00:00Z","timestamp":1788048000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2026,8,30]],"date-time":"2026-08-30T00:00:00Z","timestamp":1788048000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["U25A2073 22275129"],"award-info":[{"award-number":["U25A2073 22275129"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100031910","name":"Changping Laboratory","doi-asserted-by":"publisher","award":["2025B\u201007\u201011"],"award-info":[{"award-number":["2025B\u201007\u201011"]}],"id":[{"id":"10.13039\/100031910","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Small"],"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>Lipoic acid (LA) scavenges free radicals and was clinically tested for ischemic stroke. However, the short half\u2010life and weak efficacy in penetrating the blood\u2010brain barrier (BBB) limit its use in the brain. Here, we developed poly (lipoic acid) nanoparticles (pLANs) with a half\u2010life of more than 15 h and a high efficiency to penetrate the BBB for ischemic stroke treatment. With intraperitoneal injection, imaging studies using fluorescently labelled pLANs of different sizes revealed that 30 nm pLANs entered the brain most rapidly and provided the strongest protection against ischemic injury. In vitro, 30 nm pLANs significantly prevented cell death induced by oxygen\u2010glucose deprivation (OGD), reduced total ROS and lipid peroxides, and inhibited GPX4\u2010dependent ferroptosis. In rat models of cerebral ischemia\/reperfusion, 30 nm pLANs extended the therapeutic window by 3 h relative to LA monomer and prevented neuronal damage effectively at only half the dose. These findings demonstrate that 30 nm pLANs effectively cross the BBB, sustain drug levels in blood, and protect against neuronal death by suppressing ferroptosis, offering a promising strategy for ischemic stroke and other neurological disorders associated with oxidative stress.<\/jats:p>","DOI":"10.1002\/smll.75529","type":"journal-article","created":{"date-parts":[[2026,8,31]],"date-time":"2026-08-31T05:36:00Z","timestamp":1788154560000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Poly (Lipoic Acid) Nanoparticles With High Blood\u2010Brain Barrier Permeability and Enhanced Anti\u2010Ferroptotic Activity for Ischemic Stroke Treatment"],"prefix":"10.1002","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-8639-3789","authenticated-orcid":false,"given":"Qing\u2010Zhang","family":"Tuo","sequence":"first","affiliation":[{"name":"Department of Geriatrics and State Key Laboratory of Biotherapy National Clinical Research Center for Geriatrics West China Hospital, Sichuan University  Chengdu Sichuan Province China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Juan","family":"Tan","sequence":"additional","affiliation":[{"name":"College of Biomedical Engineering and National Engineering Research Center for Biomaterials Sichuan University  Chengdu Sichuan Province China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hong\u2010Fa","family":"Yan","sequence":"additional","affiliation":[{"name":"Department of Geriatrics and State Key Laboratory of Biotherapy National Clinical Research Center for Geriatrics West China Hospital, Sichuan University  Chengdu Sichuan Province China"},{"name":"Department of Neurology and State Key Laboratory of Biotherapy West China Hospital Sichuan University  Chengdu Sichuan Province China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xueying","family":"Zhou","sequence":"additional","affiliation":[{"name":"College of 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