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Here, we developed a drug\u2010loaded passive cooling nanocomposite hydrogel that can simultaneously regulate the physical temperature and biochemical wound microenvironment. The hydrogel is constructed from a poly(vinyl alcohol)\u2010sorbitol network incorporating sulfated cellulose nanocrystals, silica nanoparticles, and salidroside, a potent anti\u2010inflammatory phytochemical, achieving both exceptional passive cooling with a temperature drop of 6.2\u00b0C compared to non\u2010covered control under sunlight and the sustained release of salidroside. In vitro, the hydrogel exhibits time\u2010dependent antibacterial efficacy over 97% bacterial inhibition and effectively suppresses inflammation. In a murine full\u2010thickness wound model, the hydrogel promoted local cooling and accelerated wound closure, achieving near\u2010complete healing by day 11, earlier than the phosphate\u2010buffered saline control. Histological analyses confirm attenuated inflammation and enhanced tissue remodeling, as evidenced by suppressed TNF\u2010\u03b1 expression and CD68 macrophage infiltration, increased \u03b1\u2010SMA myofibroblasts, and organized collagen deposition. This work introduces a cooling\u2010and\u2010curing strategy, where material enables physical cooling and localized drug delivery to operate synergistically to disrupt the inflammatory cycle, offering a transformative platform for intelligent wound management.<\/jats:p>","DOI":"10.1002\/smll.75552","type":"journal-article","created":{"date-parts":[[2026,9,15]],"date-time":"2026-09-15T11:15:22Z","timestamp":1789470922000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Drug\u2010Loaded Passive Cooling Hydrogels for Synergistic Thermal and Anti\u2010Inflammatory Regulation of Skin Wounds"],"prefix":"10.1002","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-6079-5760","authenticated-orcid":false,"given":"Li","family":"Ding","sequence":"first","affiliation":[{"name":"Department of Food Science and Nutrition The Hong Kong Polytechnic University  Hong Kong 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