{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,13]],"date-time":"2026-10-13T10:45:06Z","timestamp":1791888306922,"version":"4.3.4"},"reference-count":238,"publisher":"Wiley","issue":"57","license":[{"start":{"date-parts":[[2026,9,15]],"date-time":"2026-09-15T00:00:00Z","timestamp":1789430400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2026,9,15]],"date-time":"2026-09-15T00:00:00Z","timestamp":1789430400000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["22225107"],"award-info":[{"award-number":["22225107"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Small"],"published-print":{"date-parts":[[2026,10]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>Liquid\u2013liquid phase separation (LLPS) is a physical process that drives the formation of biomolecular condensates, which coordinate cellular biochemical reactions in space and time. Nevertheless, these metastable condensates are susceptible to various disturbances, which trigger the occurrence of abnormal phase transitions. In neurodegeneration, this process promotes the development of misfolded proteins into toxic fibrils. In cancer, LLPS affects multiple stages of its occurrence and progression, including oncogenic signaling, gene expression, angiogenesis, metabolic reprogramming, and invasive growth. The disordered regions of proteins play an important role in these abnormal phase transitions. However, in this area, traditional lock\u2010and\u2010key pharmacology faces major challenges. Notably, due to the large specific surface area, multivalence, and tunability, nanotechnology shows substantial potential for intervention at multiple stages of pathological phase separation. These targets encompass monomers, liquid condensates, oligomers, and fibrils. In addition to traditional strategies, emerging frontiers include nanomaterial\u2010induced synthetic condensates for component sequestration and targeted disruption of oncogenic transcriptional hubs. Furthermore, computational modeling is beginning to transform LLPS research from mechanism discovery toward material rational engineering. This review provides a strategic framework for utilizing nanotechnology as a precision intervention to modulate LLPS, offering a clear path for the intervention of pathological phase separation in diverse diseases.<\/jats:p>","DOI":"10.1002\/smll.75569","type":"journal-article","created":{"date-parts":[[2026,9,15]],"date-time":"2026-09-15T13:29:53Z","timestamp":1789478993000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Nanomaterial Interventions in Pathological Biomolecular Phase Transitions of Neurodegeneration and Cancer"],"prefix":"10.1002","volume":"22","author":[{"ORCID":"https:\/\/orcid.org\/0009-0008-7567-4049","authenticated-orcid":false,"given":"Ruonan","family":"Wang","sequence":"first","affiliation":[{"name":"Key Laboratory of Structural Chemistry Fujian Institute of Research on the Structure of Matter Chinese Academy of Sciences  Fuzhou People's Republic of China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1845-2809","authenticated-orcid":false,"given":"Wei","family":"Wu","sequence":"additional","affiliation":[{"name":"MOE Key Laboratory of High Performance Polymer Materials &amp; Technology and State Key Laboratory of Analytical Chemistry for Life Science School of Chemistry &amp; Chemical Engineering, Nanjing University  Nanjing People's Republic of China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0483-0282","authenticated-orcid":false,"given":"Xiqun","family":"Jiang","sequence":"additional","affiliation":[{"name":"MOE Key Laboratory of High Performance Polymer Materials &amp; Technology and State Key Laboratory of Analytical Chemistry for Life Science School of Chemistry &amp; Chemical Engineering, Nanjing University  Nanjing People's Republic of China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1030-5089","authenticated-orcid":false,"given":"Hongli","family":"Bao","sequence":"additional","affiliation":[{"name":"Key Laboratory of Structural Chemistry Fujian Institute of Research on the Structure of Matter Chinese Academy of Sciences  Fuzhou People's Republic of China"},{"name":"College of Environment &amp; Safety Engineering Fuzhou University  Fuzhou People's Republic of China"},{"name":"University of Chinese Academy of Sciences  Beijing People's Republic of China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,9,15]]},"reference":[{"key":"e_1_2_10_2_1","doi-asserted-by":"publisher","DOI":"10.1096\/fba.2025\u201000140"},{"key":"e_1_2_10_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2018.12.035"},{"key":"e_1_2_10_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.tcb.2018.02.004"},{"key":"e_1_2_10_5_1","doi-asserted-by":"publisher","DOI":"10.1146\/annurev\u2010biophys\u2010121219\u2010081629"},{"key":"e_1_2_10_6_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12915\u2010025\u201002214\u2010x"},{"key":"e_1_2_10_7_1","doi-asserted-by":"publisher","DOI":"10.1002\/mco2.640"},{"key":"e_1_2_10_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.supmat.2023.100049"},{"key":"e_1_2_10_9_1","doi-asserted-by":"publisher","DOI":"10.1038\/s12276\u2010024\u201001337\u20105"},{"key":"e_1_2_10_10_1","doi-asserted-by":"publisher","DOI":"10.3390\/ijms21165908"},{"key":"e_1_2_10_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.matt.2022.07.001"},{"key":"e_1_2_10_12_1","doi-asserted-by":"publisher","DOI":"10.1146\/annurev\u2010biophys\u2010030722\u2010111729"},{"key":"e_1_2_10_13_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41586\u2010022\u201005138\u20106"},{"key":"e_1_2_10_14_1","doi-asserted-by":"publisher","DOI":"10.1146\/annurev\u2010biophys\u2010062920\u2010063704"},{"key":"e_1_2_10_15_1","doi-asserted-by":"publisher","DOI":"10.1021\/acs.langmuir.5c03118"},{"key":"e_1_2_10_16_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41467\u2010022\u201030521\u20102"},{"key":"e_1_2_10_17_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41557\u2010023\u201001289\u20109"},{"key":"e_1_2_10_18_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41557\u2010020\u20100465\u20109"},{"key":"e_1_2_10_19_1","doi-asserted-by":"publisher","DOI":"10.1146\/annurev\u2010biochem\u2010061516\u2010045115"},{"key":"e_1_2_10_20_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41467\u2010025\u201058335\u2010y"},{"key":"e_1_2_10_21_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.abb8032"},{"key":"e_1_2_10_22_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41392\u2010021\u201000678\u20101"},{"key":"e_1_2_10_23_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.tcb.2022.01.011"},{"key":"e_1_2_10_24_1","doi-asserted-by":"publisher","DOI":"10.1021\/acscentsci.4c01319"},{"key":"e_1_2_10_25_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.str.2016.07.007"},{"key":"e_1_2_10_26_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1912055117"},{"key":"e_1_2_10_27_1","doi-asserted-by":"publisher","DOI":"10.1186\/s10020\u2010025\u201001208\u20103"},{"key":"e_1_2_10_28_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jmb.2020.166731"},{"key":"e_1_2_10_29_1","doi-asserted-by":"publisher","DOI":"10.1021\/acs.jcim.3c00997"},{"key":"e_1_2_10_30_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.2012460117"},{"key":"e_1_2_10_31_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.tibs.2020.12.005"},{"key":"e_1_2_10_32_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41568\u2010022\u201000444\u20107"},{"key":"e_1_2_10_33_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41392\u2010022\u201001076\u2010x"},{"key":"e_1_2_10_34_1","doi-asserted-by":"publisher","DOI":"10.1111\/febs.15765"},{"key":"e_1_2_10_35_1","doi-asserted-by":"publisher","DOI":"10.3389\/fcell.2021.631486"},{"key":"e_1_2_10_36_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2020.09.002"},{"key":"e_1_2_10_37_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.biopha.2024.117448"},{"key":"e_1_2_10_38_1","doi-asserted-by":"publisher","DOI":"10.1021\/accountsmr.1c00193"},{"key":"e_1_2_10_39_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.nantod.2019.100837"},{"key":"e_1_2_10_40_1","doi-asserted-by":"publisher","DOI":"10.1021\/acs.chemrev.3c00131"},{"key":"e_1_2_10_41_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbagen.2021.130061"},{"key":"e_1_2_10_42_1","doi-asserted-by":"publisher","DOI":"10.3390\/ijms251810187"},{"key":"e_1_2_10_43_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pcbi.1012144"},{"key":"e_1_2_10_44_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrm.2017.7"},{"key":"e_1_2_10_45_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.181.4096.223"},{"key":"e_1_2_10_46_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.6801762"},{"key":"e_1_2_10_47_1","doi-asserted-by":"publisher","DOI":"10.1021\/bi00040a037"},{"key":"e_1_2_10_48_1","doi-asserted-by":"publisher","DOI":"10.1006\/jmbi.1999.3110"},{"key":"e_1_2_10_49_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1093\u20103263(00)00138\u20108"},{"key":"e_1_2_10_50_1","doi-asserted-by":"publisher","DOI":"10.1093\/bioinformatics\/btu310"},{"key":"e_1_2_10_51_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2009.02.044"},{"key":"e_1_2_10_52_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.brainres.2012.01.016"},{"key":"e_1_2_10_53_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2012.04.017"},{"key":"e_1_2_10_54_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bpj.2022.05.042"},{"key":"e_1_2_10_55_1","doi-asserted-by":"publisher","DOI":"10.1038\/nature10879"},{"key":"e_1_2_10_56_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2018.06.006"},{"key":"e_1_2_10_57_1","doi-asserted-by":"publisher","DOI":"10.1146\/annurev.cellbio.16.1.273"},{"key":"e_1_2_10_58_1","first-page":"1","volume-title":"Sumptibus Leopoldi Vossii: Lipsiae","author":"Wagner R.","year":"1836"},{"key":"e_1_2_10_59_1","first-page":"129","article-title":"Un Sencillo M\u00e9todo de Coloraci\u00f3n Selectiva del Ret\u00edculo Protopl\u00e1smico y Su Resultado en los Centros Nerviosos y en la Periferia","volume":"2","author":"Cajal S. R.","year":"1903","journal-title":"Trabajos del Laboratorio de Investigaciones Biol\u00f3gicas de la Universidad de Madrid"},{"key":"e_1_2_10_60_1","doi-asserted-by":"publisher","DOI":"10.1002\/ca.980080612"},{"key":"e_1_2_10_61_1","doi-asserted-by":"publisher","DOI":"10.1192\/bjp.74.306.533\u2010a"},{"key":"e_1_2_10_62_1","doi-asserted-by":"publisher","DOI":"10.1038\/197192b0"},{"key":"e_1_2_10_63_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0021\u20109258(17)38495\u20108"},{"key":"e_1_2_10_64_1","first-page":"229","article-title":"Mise En \u00c9vidence Immunologique de la Prot\u00e9ine Tau au Niveau Des L\u00e9sions de D\u00e9g\u00e9n\u00e9rescence Neurofibrillaire de la Maladie D'Alzheimer","volume":"95","author":"Brion J.\u2010P.","year":"1985","journal-title":"Archives of Biology (Bruxelles)"},{"key":"e_1_2_10_65_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.83.11.4044"},{"key":"e_1_2_10_66_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.83.11.4040"},{"key":"e_1_2_10_67_1","doi-asserted-by":"publisher","DOI":"10.1093\/oxfordjournals.jbchem.a135662"},{"key":"e_1_2_10_68_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.83.13.4913"},{"key":"e_1_2_10_69_1","doi-asserted-by":"publisher","DOI":"10.1093\/oxfordjournals.jbchem.a135625"},{"key":"e_1_2_10_70_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.82.12.4245"},{"key":"e_1_2_10_71_1","doi-asserted-by":"publisher","DOI":"10.1038\/349704a0"},{"key":"e_1_2_10_72_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.1566067"},{"key":"e_1_2_10_73_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.95.11.6448"},{"key":"e_1_2_10_74_1","doi-asserted-by":"publisher","DOI":"10.1038\/42166"},{"key":"e_1_2_10_75_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.276.5321.2045"},{"key":"e_1_2_10_76_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.1134108"},{"key":"e_1_2_10_77_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbrc.2006.10.093"},{"key":"e_1_2_10_78_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.1165942"},{"key":"e_1_2_10_79_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.1166066"},{"key":"e_1_2_10_80_1","doi-asserted-by":"publisher","DOI":"10.1016\/0092\u20108674(93)90635\u20104"},{"key":"e_1_2_10_81_1","doi-asserted-by":"publisher","DOI":"10.1038\/nature05695"},{"key":"e_1_2_10_82_1","doi-asserted-by":"publisher","DOI":"10.1021\/acs.jpclett.2c01986"},{"key":"e_1_2_10_83_1","doi-asserted-by":"publisher","DOI":"10.1063\/1.1723621"},{"key":"e_1_2_10_84_1","doi-asserted-by":"publisher","DOI":"10.1002\/jcp.1030490404"},{"key":"e_1_2_10_85_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.1172046"},{"key":"e_1_2_10_86_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.aaw4951"},{"key":"e_1_2_10_87_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41594\u2010019\u20100193\u20102"},{"key":"e_1_2_10_88_1","doi-asserted-by":"publisher","DOI":"10.7554\/eLife.21337"},{"key":"e_1_2_10_89_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2020.03.049"},{"key":"e_1_2_10_90_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2016.07.008"},{"key":"e_1_2_10_91_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.aar3958"},{"key":"e_1_2_10_92_1","doi-asserted-by":"publisher","DOI":"10.1038\/nature11922"},{"key":"e_1_2_10_93_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2015.09.015"},{"key":"e_1_2_10_94_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2015.07.047"},{"key":"e_1_2_10_95_1","doi-asserted-by":"publisher","DOI":"10.1093\/jmcb\/mjaa049"},{"key":"e_1_2_10_96_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1614462114"},{"key":"e_1_2_10_97_1","doi-asserted-by":"publisher","DOI":"10.3389\/fnmol.2019.00025"},{"key":"e_1_2_10_98_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41467\u2010017\u201000480\u20100"},{"key":"e_1_2_10_99_1","doi-asserted-by":"publisher","DOI":"10.3390\/biom13050726"},{"key":"e_1_2_10_100_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0022\u20102836(02)00848\u20103"},{"key":"e_1_2_10_101_1","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M112.340638"},{"key":"e_1_2_10_102_1","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.RA118.003285"},{"key":"e_1_2_10_103_1","doi-asserted-by":"publisher","DOI":"10.4161\/pri.27776"},{"key":"e_1_2_10_104_1","doi-asserted-by":"publisher","DOI":"10.1021\/acs.accounts.7b00473"},{"key":"e_1_2_10_105_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.molcel.2018.08.027"},{"key":"e_1_2_10_106_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41556\u2010019\u20100433\u2010z"},{"key":"e_1_2_10_107_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41586\u2010021\u201003662\u20105"},{"key":"e_1_2_10_108_1","doi-asserted-by":"publisher","DOI":"10.1002\/1878\u20100261.13259"},{"key":"e_1_2_10_109_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.canlet.2025.217508"},{"key":"e_1_2_10_110_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jare.2025.03.013"},{"key":"e_1_2_10_111_1","doi-asserted-by":"publisher","DOI":"10.1083\/jcb.202008030"},{"key":"e_1_2_10_112_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.aaz4427"},{"key":"e_1_2_10_113_1","doi-asserted-by":"publisher","DOI":"10.1007\/978-1-0716-2663-4_4"},{"key":"e_1_2_10_114_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41589\u2010022\u201001175\u20104"},{"key":"e_1_2_10_115_1","doi-asserted-by":"publisher","DOI":"10.1103\/PRXLife.2.023011"},{"key":"e_1_2_10_116_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41589\u2010022\u201001046\u2010y"},{"key":"e_1_2_10_117_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.molcel.2024.12.021"},{"key":"e_1_2_10_118_1","doi-asserted-by":"publisher","DOI":"10.1186\/s43556\u2010025\u201000350\u2010y"},{"key":"e_1_2_10_119_1","doi-asserted-by":"publisher","DOI":"10.1021\/acs.chemrev.4c00138"},{"key":"e_1_2_10_120_1","doi-asserted-by":"publisher","DOI":"10.1038\/s42254\u2010023\u201000598\u20109"},{"key":"e_1_2_10_121_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.2401307122"},{"key":"e_1_2_10_122_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41467\u2010022\u201032940\u20107"},{"key":"e_1_2_10_123_1","doi-asserted-by":"publisher","DOI":"10.1063\/5.0236610"},{"key":"e_1_2_10_124_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.2210177119"},{"key":"e_1_2_10_125_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.2220014120"},{"key":"e_1_2_10_126_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41589\u2010022\u201001204\u20102"},{"key":"e_1_2_10_127_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.aaf4382"},{"key":"e_1_2_10_128_1","doi-asserted-by":"publisher","DOI":"10.7150\/thno.127750"},{"key":"e_1_2_10_129_1","doi-asserted-by":"publisher","DOI":"10.3390\/ijms27020837"},{"key":"e_1_2_10_130_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41589\u2010025\u201001893\u20105"},{"key":"e_1_2_10_131_1","doi-asserted-by":"publisher","DOI":"10.3390\/nano15100704"},{"key":"e_1_2_10_132_1","doi-asserted-by":"publisher","DOI":"10.3389\/fcell.2021.642623"},{"key":"e_1_2_10_133_1","doi-asserted-by":"publisher","DOI":"10.3390\/ijms232113428"},{"key":"e_1_2_10_134_1","doi-asserted-by":"publisher","DOI":"10.1146\/annurev\u2010biophys\u2010080124\u2010122953"},{"key":"e_1_2_10_135_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2023.11.025"},{"key":"e_1_2_10_136_1","doi-asserted-by":"publisher","DOI":"10.3389\/fbioe.2020.00532"},{"key":"e_1_2_10_137_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41467\u2010025\u201063459\u20102"},{"key":"e_1_2_10_138_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41467\u2010025\u201063458\u20103"},{"key":"e_1_2_10_139_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.nano.2016.10.006"},{"key":"e_1_2_10_140_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.nantod.2022.101388"},{"key":"e_1_2_10_141_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41467\u2010019\u201011762\u20100"},{"key":"e_1_2_10_142_1","doi-asserted-by":"publisher","DOI":"10.1021\/acs.chemmater.1c01947"},{"key":"e_1_2_10_143_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jcis.2024.05.193"},{"key":"e_1_2_10_144_1","doi-asserted-by":"publisher","DOI":"10.1002\/advs.201901844"},{"key":"e_1_2_10_145_1","doi-asserted-by":"publisher","DOI":"10.1002\/anie.201400735"},{"key":"e_1_2_10_146_1","doi-asserted-by":"publisher","DOI":"10.1021\/acsmacrolett.8b00495"},{"key":"e_1_2_10_147_1","doi-asserted-by":"publisher","DOI":"10.1021\/acs.nanolett.5c03426"},{"key":"e_1_2_10_148_1","doi-asserted-by":"publisher","DOI":"10.1021\/acscentsci.5c00519"},{"key":"e_1_2_10_149_1","doi-asserted-by":"publisher","DOI":"10.1021\/acsami.5c12708"},{"key":"e_1_2_10_150_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.2403049121"},{"key":"e_1_2_10_151_1","doi-asserted-by":"publisher","DOI":"10.1021\/acsnano.3c08823"},{"key":"e_1_2_10_152_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41467\u2010023\u201041489\u2010y"},{"key":"e_1_2_10_153_1","doi-asserted-by":"publisher","DOI":"10.1021\/jacs.5c00105"},{"key":"e_1_2_10_154_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12274\u2010016\u20101000\u20106"},{"key":"e_1_2_10_155_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.biomaterials.2016.05.005"},{"key":"e_1_2_10_156_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41565\u2010018\u20100179\u2010y"},{"key":"e_1_2_10_157_1","doi-asserted-by":"publisher","DOI":"10.1126\/sciadv.adl2991"},{"key":"e_1_2_10_158_1","doi-asserted-by":"publisher","DOI":"10.7150\/thno.76574"},{"key":"e_1_2_10_159_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41467\u2010018\u201004255\u2010z"},{"key":"e_1_2_10_160_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.nantod.2024.102168"},{"key":"e_1_2_10_161_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.apsb.2021.04.022"},{"key":"e_1_2_10_162_1","doi-asserted-by":"publisher","DOI":"10.1002\/EXP.20230048"},{"key":"e_1_2_10_163_1","doi-asserted-by":"publisher","DOI":"10.1021\/acsnano.0c10690"},{"key":"e_1_2_10_164_1","doi-asserted-by":"publisher","DOI":"10.1002\/adma.202313869"},{"key":"e_1_2_10_165_1","doi-asserted-by":"publisher","DOI":"10.3390\/jfb14040207"},{"key":"e_1_2_10_166_1","doi-asserted-by":"publisher","DOI":"10.1002\/adfm.202401208"},{"key":"e_1_2_10_167_1","doi-asserted-by":"publisher","DOI":"10.1126\/sciadv.ado4927"},{"key":"e_1_2_10_168_1","doi-asserted-by":"publisher","DOI":"10.1002\/anie.202405605"},{"key":"e_1_2_10_169_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12967\u2010023\u201004082\u2010x"},{"key":"e_1_2_10_170_1","doi-asserted-by":"publisher","DOI":"10.1038\/s42004\u2010024\u201001289\u2010x"},{"key":"e_1_2_10_171_1","doi-asserted-by":"publisher","DOI":"10.1172\/jci.insight.170340"},{"key":"e_1_2_10_172_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.molcel.2021.07.040"},{"key":"e_1_2_10_173_1","doi-asserted-by":"publisher","DOI":"10.1101\/gad.351667.124"},{"key":"e_1_2_10_174_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cub.2023.04.012"},{"key":"e_1_2_10_175_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.tibs.2021.01.002"},{"key":"e_1_2_10_176_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41467\u2010025\u201064623\u20104"},{"key":"e_1_2_10_177_1","doi-asserted-by":"publisher","DOI":"10.3389\/fmolb.2022.869851"},{"key":"e_1_2_10_178_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41467\u2010021\u201023985\u20101"},{"key":"e_1_2_10_179_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bpj.2022.10.013"},{"key":"e_1_2_10_180_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41419\u2010024\u201006429\u20108"},{"key":"e_1_2_10_181_1","doi-asserted-by":"publisher","DOI":"10.1021\/nn5014484"},{"key":"e_1_2_10_182_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.nano.2014.09.005"},{"key":"e_1_2_10_183_1","doi-asserted-by":"publisher","DOI":"10.1021\/acsbiomaterials.9b00006"},{"key":"e_1_2_10_184_1","doi-asserted-by":"publisher","DOI":"10.1038\/mt.2015.225"},{"key":"e_1_2_10_185_1","doi-asserted-by":"publisher","DOI":"10.1039\/C6BM00449K"},{"key":"e_1_2_10_186_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12274\u2010019\u20102308\u20109"},{"key":"e_1_2_10_187_1","doi-asserted-by":"publisher","DOI":"10.1126\/scitranslmed.aaw1565"},{"key":"e_1_2_10_188_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41467\u2010022\u201028279\u20108"},{"key":"e_1_2_10_189_1","doi-asserted-by":"publisher","DOI":"10.1002\/cac2.12511"},{"key":"e_1_2_10_190_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.2304966120"},{"key":"e_1_2_10_191_1","doi-asserted-by":"publisher","DOI":"10.1021\/jacs.4c17920"},{"key":"e_1_2_10_192_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jconrel.2022.07.020"},{"key":"e_1_2_10_193_1","doi-asserted-by":"publisher","DOI":"10.1002\/advs.202500825"},{"key":"e_1_2_10_194_1","doi-asserted-by":"publisher","DOI":"10.1021\/acs.jmedchem.5c00670"},{"key":"e_1_2_10_195_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijbiomac.2025.140765"},{"key":"e_1_2_10_196_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41467\u2010022\u201032268\u20102"},{"key":"e_1_2_10_197_1","doi-asserted-by":"publisher","DOI":"10.1021\/acsnano.3c04112"},{"key":"e_1_2_10_198_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41565\u2010023\u201001562\u20105"},{"key":"e_1_2_10_199_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12951\u2010023\u201001867\u20106"},{"key":"e_1_2_10_200_1","doi-asserted-by":"publisher","DOI":"10.1002\/anie.202212671"},{"key":"e_1_2_10_201_1","doi-asserted-by":"publisher","DOI":"10.1002\/adfm.202312610"},{"key":"e_1_2_10_202_1","doi-asserted-by":"publisher","DOI":"10.1021\/acsami.2c18020"},{"key":"e_1_2_10_203_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41467\u2010024\u201047080\u20103"},{"key":"e_1_2_10_204_1","doi-asserted-by":"publisher","DOI":"10.1002\/advs.202307278"},{"key":"e_1_2_10_205_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12951\u2010022\u201001647\u20108"},{"key":"e_1_2_10_206_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41586\u2010024\u201008421\u2010w"},{"key":"e_1_2_10_207_1","doi-asserted-by":"publisher","DOI":"10.1038\/s43018\u2010023\u201000522\u20101"},{"key":"e_1_2_10_208_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41589\u2010022\u201001151\u2010y"},{"key":"e_1_2_10_209_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41422\u2010021\u201000504\u2010x"},{"key":"e_1_2_10_210_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41467\u2010023\u201041864\u20109"},{"key":"e_1_2_10_211_1","doi-asserted-by":"publisher","DOI":"10.1021\/acs.chemrev.2c00586"},{"key":"e_1_2_10_212_1","doi-asserted-by":"publisher","DOI":"10.1039\/c5ra20182a"},{"key":"e_1_2_10_213_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jcis.2022.04.134"},{"key":"e_1_2_10_214_1","doi-asserted-by":"publisher","DOI":"10.1039\/c8nr04506b"},{"key":"e_1_2_10_215_1","doi-asserted-by":"publisher","DOI":"10.1002\/adma.202510115"},{"key":"e_1_2_10_216_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41594\u2010019\u20100250\u2010x"},{"key":"e_1_2_10_217_1","doi-asserted-by":"publisher","DOI":"10.1021\/acs.jpcb.0c06288"},{"key":"e_1_2_10_218_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41467\u2010021\u201021181\u20109"},{"key":"e_1_2_10_219_1","doi-asserted-by":"publisher","DOI":"10.1021\/jacs.2c13647"},{"key":"e_1_2_10_220_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41586\u2010023\u201006329\u20105"},{"key":"e_1_2_10_221_1","doi-asserted-by":"publisher","DOI":"10.1038\/s43588\u2010021\u201000155\u20103"},{"key":"e_1_2_10_222_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.2111696118"},{"key":"e_1_2_10_223_1","doi-asserted-by":"publisher","DOI":"10.1021\/acs.jctc.2c01273"},{"key":"e_1_2_10_224_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pcbi.1012737"},{"key":"e_1_2_10_225_1","doi-asserted-by":"publisher","DOI":"10.1021\/acscentsci.4c01617"},{"key":"e_1_2_10_226_1","doi-asserted-by":"publisher","DOI":"10.1002\/cbic.202200450"},{"key":"e_1_2_10_227_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.2201250119"},{"key":"e_1_2_10_228_1","doi-asserted-by":"publisher","DOI":"10.3390\/ijms24086896"},{"key":"e_1_2_10_229_1","doi-asserted-by":"publisher","DOI":"10.1002\/advs.202511545"},{"key":"e_1_2_10_230_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41467\u2010023\u201036443\u2010x"},{"key":"e_1_2_10_231_1","doi-asserted-by":"publisher","DOI":"10.1021\/acs.jcim.5c01281"},{"key":"e_1_2_10_232_1","doi-asserted-by":"publisher","DOI":"10.1002\/advs.202511636"},{"key":"e_1_2_10_233_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.2019053118"},{"key":"e_1_2_10_234_1","doi-asserted-by":"publisher","DOI":"10.7554\/eLife.97709"},{"key":"e_1_2_10_235_1","doi-asserted-by":"publisher","DOI":"10.1021\/jacsau.5c00291"},{"key":"e_1_2_10_236_1","doi-asserted-by":"publisher","DOI":"10.1093\/bioinformatics\/btaf321"},{"key":"e_1_2_10_237_1","doi-asserted-by":"publisher","DOI":"10.1021\/acsnano.4c12259"},{"key":"e_1_2_10_238_1","doi-asserted-by":"publisher","DOI":"10.1039\/D5NA00425J"},{"key":"e_1_2_10_239_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.2113297119"}],"container-title":["Small"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/smll.75569","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1002\/smll.75569","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/smll.75569","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,10,13]],"date-time":"2026-10-13T09:48:33Z","timestamp":1791884913000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/smll.75569"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,9,15]]},"references-count":238,"journal-issue":{"issue":"57","published-print":{"date-parts":[[2026,10]]}},"alternative-id":["10.1002\/smll.75569"],"URL":"https:\/\/doi.org\/10.1002\/smll.75569","archive":["Portico"],"relation":{},"ISSN":["1613-6810","1613-6829"],"issn-type":[{"value":"1613-6810","type":"print"},{"value":"1613-6829","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,9,15]]},"assertion":[{"value":"2026-05-19","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-08-24","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-09-15","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e75569"}}