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Developing hemostatic materials with rapid expansion, effective coagulation promotion, good biocompatibility, and tissue regeneration is still urgently needed. This study reports a simple regioselective dual\u2010oxidation (RDO) strategy for fabricating crosslinker\u2010free hemostatic sponges from bacterial cellulose (BC) with high porosity. Carboxyl and aldehyde groups were both introduced into the BC scaffold after TEMPO\u2010mediated oxidation and sodium periodate oxidation. The dual\u2010oxidation BC (DOBC) sponges retained the 3D nanofibrous architecture and rapid shape recovery, associated with aldehyde\u2010driven hemiacetal network formation and enhanced blood interactions. Meanwhile, the sponges exhibited favorable mechanical properties, excellent biocompatibility, high liquid absorption capacity, antibacterial activity, and rapid whole\u2010blood coagulation. Notably, DOBC sponges effectively enrich red blood cells and platelets, further promoting rapid hemostasis. In vivo studies demonstrate that DOBC sponges effectively control bleeding in rat models of NCH and outperform gauze and commercial gelatin sponges. Moreover, they promoted cell infiltration, angiogenesis, and liver tissue regeneration. This study proposes a simple dual\u2010oxidation, crosslinker\u2010free strategy for preparing hemostatic sponges, thereby offering a promising solution for rapid hemostasis and subsequent tissue repair in non\u2010compressible wounds.<\/jats:p>","DOI":"10.1002\/smll.75607","type":"journal-article","created":{"date-parts":[[2026,9,7]],"date-time":"2026-09-07T10:27:16Z","timestamp":1788776836000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Dual\u2010Oxidation Bacterial Cellulose Sponges with Rapid Shape Recovery for Crosslinker\u2010Free Noncompressible Hemostasis and Tissue Regeneration"],"prefix":"10.1002","author":[{"given":"Yiting","family":"Jiang","sequence":"first","affiliation":[{"name":"Hubei Engineering Center of Natural Polymers\u2010based Medical Materials Key Laboratory of Biomedical Polymers of Ministry of Education College of Chemistry and Molecular Sciences Wuhan University  Wuhan 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