{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,23]],"date-time":"2026-09-23T13:59:50Z","timestamp":1790171990398,"version":"4.1.0"},"reference-count":59,"publisher":"Wiley","license":[{"start":{"date-parts":[[2026,9,23]],"date-time":"2026-09-23T00:00:00Z","timestamp":1790121600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2026,9,23]],"date-time":"2026-09-23T00:00:00Z","timestamp":1790121600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82372127"],"award-info":[{"award-number":["82372127"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Small"],"abstract":"ABSTRACT<\/jats:title>\n \n While singlet oxygen (\n 1<\/jats:sup>\n O\n 2<\/jats:sub>\n )\u2010based therapies like photodynamic therapy (PDT) demonstrate clinical anticancer efficacy, their dependence on external light and substantial O\n 2<\/jats:sub>\n consumption significantly limits their broader application. To surmount these constraints, we develop a chemiexcited (light\u2010independent) PDT platform by encapsulating bis[2,4,5\u2010trichloro\u20106\u2010(pentyloxycarbonyl) phenyl] oxalate (CPPO) and chlorin e6 (Ce6) within the 1,2\u2010distearoyl\u2010\n sn<\/jats:italic>\n \u2010glycero\u20103\u2010phosphoethanolamine\u2010\n N<\/jats:italic>\n \u2010[methoxy(poly\u00adethyleneglycol)\u20102000] (ammonium salt) (DSPE\u2010PEG\n 2000<\/jats:sub>\n \u2010OMe) micelle (termed CCM). The CCM is then incorporated along with vitamin C (Vc) into a Ca\n 2+<\/jats:sup>\n \u2013alginate hydrogel, forming a final product denoted as CCMVH. Following intratumoral injection of CCMVH, the sustained Vc release continuously elevates the tumoral H\n 2<\/jats:sub>\n O\n 2<\/jats:sub>\n level. Subsequent reaction of H\n 2<\/jats:sub>\n O\n 2<\/jats:sub>\n with CPPO generates chemical energy, activating Ce6 to produce\n 1<\/jats:sup>\n O\n 2<\/jats:sub>\n without light. More importantly, we employ hyperbaric oxygen (HBO) to sustain the high intratumoral O\n 2<\/jats:sub>\n level during chemiexcited PDT. The synergy between Vc\u2010driven H\n 2<\/jats:sub>\n O\n 2<\/jats:sub>\n generation and HBO\u2010mediated O\n 2<\/jats:sub>\n supply creates a dual\u2010pronged amplification effect that significantly enhances\n 1<\/jats:sup>\n O\n 2<\/jats:sub>\n production. In addition, this light\u2010independent PDT induces marked immunogenic cell death, promotes the infiltration of antitumor immune cells, and reprograms the immunosuppressive tumor microenvironment, resulting in potent tumor inhibition. This work provides a facile strategy for overcoming the fundamental limitations of conventional PDT, offering a translatable approach for cancer immunotherapy.\n <\/jats:p>","DOI":"10.1002\/smll.75619","type":"journal-article","created":{"date-parts":[[2026,9,23]],"date-time":"2026-09-23T13:02:58Z","timestamp":1790168578000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Dual\u2010Pronged Light\u2010Free Photodynamic Immunotherapy Enabled by a Chemiexcited Hydrogel"],"prefix":"10.1002","author":[{"given":"Rufeng","family":"Zhang","sequence":"first","affiliation":[{"name":"State Key Laboratory of Digital Medical Engineering Jiangsu Key Laboratory for Biomaterials and Devices School of Biological Science and Medical Engineering Southeast University Nanjing P. R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8649-7809","authenticated-orcid":false,"given":"Xiaoyang","family":"Liu","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Digital Medical Engineering Jiangsu Key Laboratory for Biomaterials and Devices School of Biological Science and Medical Engineering Southeast University Nanjing P. R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shi\u2010Hao","family":"Wang","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Digital Medical Engineering Jiangsu Key Laboratory for Biomaterials and Devices School of Biological Science and Medical Engineering Southeast University Nanjing P. R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rong","family":"Zhou","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Digital Medical Engineering Jiangsu Key Laboratory for Biomaterials and Devices School of Biological Science and Medical Engineering Southeast University Nanjing P. R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qi","family":"Gong","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Digital Medical Engineering Jiangsu Key Laboratory for Biomaterials and Devices School of Biological Science and Medical Engineering Southeast University Nanjing P. R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zi\u2010Xi","family":"Wang","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Digital Medical Engineering Jiangsu Key Laboratory for Biomaterials and Devices School of Biological Science and Medical Engineering Southeast University Nanjing P. R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2839-6305","authenticated-orcid":false,"given":"Ke\u2010Fei","family":"Xu","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Digital Medical Engineering Jiangsu Key Laboratory for Biomaterials and Devices School of Biological Science and Medical Engineering Southeast University Nanjing P. R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yi","family":"Luo","sequence":"additional","affiliation":[{"name":"Zhejiang University\u2013University of Edinburgh Institute Zhejiang University Hangzhou P. R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3307-1652","authenticated-orcid":false,"given":"Shouhua","family":"Luo","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Digital Medical Engineering Jiangsu Key Laboratory for Biomaterials and Devices School of Biological Science and Medical Engineering Southeast University Nanjing P. R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yidong","family":"Zhong","sequence":"additional","affiliation":[{"name":"Department of Pharmacy and Shandong Provincial Key Traditional Chinese Medical Discipline of Clinical Chinese Pharmacy Shandong Cancer Hospital and Institute Shandong First Medical University and Shandong Academy of Medical Sciences Jinan P. R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0498-1323","authenticated-orcid":false,"given":"Qiming","family":"Xu","sequence":"additional","affiliation":[{"name":"Beijing Jishuitan Hospital Capital Medical University Beijing P. R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1773-2868","authenticated-orcid":false,"given":"Fu\u2010Gen","family":"Wu","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Digital Medical Engineering Jiangsu Key Laboratory for Biomaterials and Devices School of Biological Science and Medical Engineering Southeast University Nanjing P. R. China"},{"name":"Nanjing Key Laboratory of Intelligent Obstetrics and Gynecology Medicine Department of Obstetrics and Gynecology Zhongda Hospital School of Medicine Southeast University Nanjing P. R. 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