{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,12]],"date-time":"2026-09-12T07:14:28Z","timestamp":1789197268330,"version":"build-2803163510"},"reference-count":75,"publisher":"Wiley","license":[{"start":{"date-parts":[[2026,9,11]],"date-time":"2026-09-11T00:00:00Z","timestamp":1789084800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,9,11]],"date-time":"2026-09-11T00:00:00Z","timestamp":1789084800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/501100000038","name":"Natural Sciences and Engineering Research Council of Canada","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100000038","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100000266","name":"Engineering and Physical Sciences Research Council","doi-asserted-by":"publisher","award":["EP\/P001114\/1"],"award-info":[{"award-number":["EP\/P001114\/1"]}],"id":[{"id":"10.13039\/501100000266","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100000266","name":"Engineering and Physical Sciences Research Council","doi-asserted-by":"publisher","award":["EP\/T020792\/1"],"award-info":[{"award-number":["EP\/T020792\/1"]}],"id":[{"id":"10.13039\/501100000266","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100000265","name":"Medical Research Council","doi-asserted-by":"publisher","award":["MR\/R015651\/1"],"award-info":[{"award-number":["MR\/R015651\/1"]}],"id":[{"id":"10.13039\/501100000265","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100031278","name":"Department for Science, Innovation and Technology","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100031278","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100000287","name":"Royal Academy of Engineering","doi-asserted-by":"publisher","award":["CiET2021\/94"],"award-info":[{"award-number":["CiET2021\/94"]}],"id":[{"id":"10.13039\/501100000287","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Small"],"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>Oral drug delivery is widely accessible to\u00a0patients for the treatment of gastrointestinal diseases such as gastric ulcers. However, the efficacy of orally delivered drugs is often hindered by their short duration of acting and low local drug concentration, due to the dynamic environment of the gastrointestinal tract. Oral microneedle drug delivery systems offer a promising solution for achieving long\u2010term drug release at target sites by inserting microneedles into tissues to prolong drug retention. Yet, their effectiveness is compromised by poor flexibility, which impedes microneedle insertion into rugose tissues. Herein, we introduce a kirigami\u2010inspired deployable microneedle robot (KiriBot) featuring a porous network of cut patterns designed to enhance tissue attachment and facilitate microneedle insertion into the target tissue wall. KiriBot consists of a multilayer foldable microneedle patch that integrates sequential chemical and magnetic actuation to control both microneedle insertion and targeted drug release. Through in vitro and ex vivo evaluation under direct visual observation, we demonstrate that the kirigami design significantly improves flexibility and enables remote magnetic control for targeted microneedle insertion. These proof\u2010of\u2010concept results highlight the potential of KiriBot for localized gastrointestinal drug delivery, while in vivo device localization and magnetic actuation across clinically relevant conditions remain to be established.<\/jats:p>","DOI":"10.1002\/smll.75632","type":"journal-article","created":{"date-parts":[[2026,9,12]],"date-time":"2026-09-12T06:55:06Z","timestamp":1789196106000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Kirigami\u2010Inspired Deployable Microneedle Robot With Enhanced Conformability for Targeted Oral Drug Delivery"],"prefix":"10.1002","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-4109-5926","authenticated-orcid":false,"given":"Kun","family":"Zhou","sequence":"first","affiliation":[{"name":"Department of Materials Department of Bioengineering, and Institute of Biomedical Engineering Imperial College London  London 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of Biomedical Engineering Imperial College London  London UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Junliang","family":"Lin","sequence":"additional","affiliation":[{"name":"Department of Materials Department of Bioengineering, and Institute of Biomedical Engineering Imperial College London  London UK"},{"name":"Department of Physiology Anatomy and Genetics Department of Engineering Science, and Kavli Institute for Nanoscience Discovery University of Oxford  Oxford UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0000-4325-034X","authenticated-orcid":false,"given":"Yiming","family":"Ma","sequence":"additional","affiliation":[{"name":"Department of Materials Department of Bioengineering, and Institute of Biomedical Engineering Imperial College London  London UK"},{"name":"Department of Physiology Anatomy and Genetics Department of Engineering Science, and Kavli Institute for Nanoscience Discovery University of Oxford  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