{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,8]],"date-time":"2026-09-08T07:08:04Z","timestamp":1788851284986,"version":"build-2803163510"},"reference-count":63,"publisher":"Wiley","license":[{"start":{"date-parts":[[2026,9,7]],"date-time":"2026-09-07T00:00:00Z","timestamp":1788739200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2026,9,7]],"date-time":"2026-09-07T00:00:00Z","timestamp":1788739200000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["52373029"],"award-info":[{"award-number":["52373029"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Small"],"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>\n                    Chronic diabetic wounds are difficult to heal due to sustained hyperglycemia, excessive oxidative stress, bacterial biofilm infection, and impaired immune regulation. Current wound dressings often lack the ability to sense pathological glucose levels and to deliver antibacterial and regenerative functions in a controlled and coordinated manner. Here, we develop a glucose\u2010responsive catalytic hydrogel that integrates enzyme\u2010metal hybrid nanozymes within a dynamic polymer network for intelligent diabetic wound therapy. Glucose oxidase (GOx) is immobilized in a hydrogen\u2010bonded organic framework (HOF) to form stable nanozymes, while Cu\n                    <jats:sup>2+<\/jats:sup>\n                    ions are incorporated to enable glucose\u2010triggered cascade catalysis, initiating a Fenton\u2010like reaction for localized antibacterial action. These nanozymes are embedded into a self\u2010healing hydrogel based on oxidized sodium alginate (OSA), carboxymethyl chitosan (CMCS), and acrylamide (Am), forming a tough and bio\u2010adhesive scaffold through dynamic Schiff\u2010base cross\u2010linking. The resulting hydrogel exhibits glucose\u2010regulated reactive oxygen species generation, efficient biofilm eradication, redox\u2010mediated immune modulation, and enhanced angiogenesis, thereby accelerating diabetic wound healing both in vitro and in vivo. This work presents a biocompatible and spatially organized enzyme\u2010metal\u2010hydrogel platform that couples metabolic sensing with controlled chemodynamic therapy, offering a promising strategy for next\u2010generation intelligent wound dressings.\n                  <\/jats:p>","DOI":"10.1002\/smll.75658","type":"journal-article","created":{"date-parts":[[2026,9,8]],"date-time":"2026-09-08T06:21:55Z","timestamp":1788848515000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Glucose\u2010Triggered Cascade ROS\u2010Regulating via Metal\u2010Hybrid Hydrogen\u2010Bonded Organic Framework Integrated Hydrogels for Diabetic Wound Healing"],"prefix":"10.1002","author":[{"given":"Chunyang","family":"Zhang","sequence":"first","affiliation":[{"name":"Beijing Laboratory of Biomedical Materials Beijing University of Chemical Technology  Beijing People's Republic of China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zerong","family":"Hou","sequence":"additional","affiliation":[{"name":"Beijing Laboratory of Biomedical Materials Beijing University of Chemical Technology  Beijing People's Republic of China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Haibo","family":"Wang","sequence":"additional","affiliation":[{"name":"Beijing Laboratory of Biomedical Materials Beijing University of Chemical Technology  Beijing People's Republic of China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hao","family":"Zhou","sequence":"additional","affiliation":[{"name":"Beijing Laboratory of Biomedical Materials Beijing University of Chemical Technology  Beijing People's Republic of China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fulin","family":"Huai","sequence":"additional","affiliation":[{"name":"Beijing Laboratory of Biomedical Materials Beijing University of Chemical Technology  Beijing People's Republic of China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jinyuan","family":"Song","sequence":"additional","affiliation":[{"name":"School of Materials Science and Engineering Nanyang Technological University  Singapore Singapore"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Liangyu","family":"Wang","sequence":"additional","affiliation":[{"name":"Beijing Laboratory of Biomedical Materials Beijing University of Chemical Technology  Beijing People's Republic of China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jun","family":"Nie","sequence":"additional","affiliation":[{"name":"Beijing Laboratory of Biomedical Materials Beijing University of Chemical Technology  Beijing People's Republic of China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6796-1613","authenticated-orcid":false,"given":"Dongzhi","family":"Yang","sequence":"additional","affiliation":[{"name":"Jiangsu Key Laboratory of New Drug Research and Clinical Pharmacy Xuzhou Medical University  Xuzhou Jiangsu People's Republic of China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9733-0414","authenticated-orcid":false,"given":"Qidong","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of Orthopaedic Surgery China\u2010Japan Friendship Hospital  Beijing People's Republic of China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4800-2414","authenticated-orcid":false,"given":"Guiping","family":"Ma","sequence":"additional","affiliation":[{"name":"Beijing Laboratory of Biomedical Materials Beijing University of Chemical Technology  Beijing People's 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