{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,8]],"date-time":"2026-09-08T10:14:57Z","timestamp":1788862497904,"version":"build-2803163510"},"reference-count":34,"publisher":"Wiley","license":[{"start":{"date-parts":[[2026,9,8]],"date-time":"2026-09-08T00:00:00Z","timestamp":1788825600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2026,9,8]],"date-time":"2026-09-08T00:00:00Z","timestamp":1788825600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82272055"],"award-info":[{"award-number":["82272055"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82272137"],"award-info":[{"award-number":["82272137"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["32571586"],"award-info":[{"award-number":["32571586"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82302363"],"award-info":[{"award-number":["82302363"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Small"],"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>\n                    Early\u2010stage hepatocellular carcinoma diagnosis is hindered by the inability of conventional MRI to concurrently detect tiny tumors and delineate their microvascular networks. To address this, we engineered sequence\u2010programmable iron oxide nanoparticles with precisely tuned magnetic properties that enable dual\u2010phase T\n                    <jats:sub>1<\/jats:sub>\n                    \u2010weighted imaging tailored to specific MRI sequences. Under ultra\u2010short TR\/TE angiography sequences, these nanoparticles produce strong T\n                    <jats:sub>1<\/jats:sub>\n                    \u2010positive enhancement, allowing high\u2010resolution visualization of tumor neovasculature down to 0.3\u00a0mm (in rabbits) at one\u2010quarter of the standard gadolinium dose. Following selective uptake and aggregation by Kupffer cells, the same nanoparticles induce localized magnetic field inhomogeneity, generating pronounced T\n                    <jats:sub>1<\/jats:sub>\n                    \u2010negative contrast in normal liver parenchyma on conventional sequences and thereby highlighting HCC lesions independent of OATP expression with detection sensitivity down to 0.4\u00a0mm (in mouse). This single\u2010agent, dual\u2010phase strategy integrates sensitive lesion detection with detailed vascular phenotyping, and is enabled by a green, scalable synthesis using an FDA\u2010approved biocompatible polymer. By overcoming key limitations of current gadolinium\u2010based agents, our platform provides a versatile and high\u2010performance imaging solution for comprehensive early\u2010stage HCC evaluation.\n                  <\/jats:p>","DOI":"10.1002\/smll.75669","type":"journal-article","created":{"date-parts":[[2026,9,8]],"date-time":"2026-09-08T09:51:25Z","timestamp":1788861085000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Sequence\u2010Programmable Iron Oxide Nanoparticles Enable Dual\u2010Phase T\n                    <sub>1<\/sub>\n                    \u2010Weighted MRI of Ultrasmall Hepatocellular Carcinoma and Tumor Vascular Architecture"],"prefix":"10.1002","author":[{"ORCID":"https:\/\/orcid.org\/0009-0007-7096-2757","authenticated-orcid":false,"given":"Tianming","family":"Cui","sequence":"first","affiliation":[{"name":"Shanghai Research Institute for Intelligent Autonomous Systems Tongji University  Shanghai China"},{"name":"Department of Medical Imaging, Tongji Hospital Shanghai Frontiers Science Center of Nanocatalytic Medicine the Institute for Biomedical Engineering &amp; Nano Science School of Medicine Tongji University  Shanghai China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yun","family":"Xu","sequence":"additional","affiliation":[{"name":"Department of Medical Imaging, Tongji Hospital Shanghai Frontiers Science Center of Nanocatalytic Medicine the Institute for Biomedical Engineering &amp; Nano Science School of Medicine Tongji University  Shanghai China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1657-292X","authenticated-orcid":false,"given":"Weitao","family":"Yang","sequence":"additional","affiliation":[{"name":"Department of Medical Imaging, Tongji Hospital Shanghai Frontiers Science Center of Nanocatalytic Medicine the Institute for Biomedical Engineering &amp; Nano Science School of Medicine Tongji University  Shanghai China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wenli","family":"Yang","sequence":"additional","affiliation":[{"name":"Department of Medical Imaging, Tongji Hospital Shanghai Frontiers Science Center of Nanocatalytic Medicine the Institute for Biomedical Engineering &amp; Nano Science School of Medicine Tongji University  Shanghai China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Youyi","family":"Yu","sequence":"additional","affiliation":[{"name":"Department of Medical Imaging, Tongji Hospital Shanghai Frontiers Science Center of Nanocatalytic Medicine the Institute for Biomedical Engineering &amp; Nano Science School of Medicine Tongji University  Shanghai China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dinghua","family":"Liu","sequence":"additional","affiliation":[{"name":"Department of Medical Imaging, Tongji Hospital Shanghai Frontiers Science Center of Nanocatalytic Medicine the Institute for Biomedical Engineering &amp; Nano Science School of Medicine Tongji University  Shanghai China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mengdi","family":"Liu","sequence":"additional","affiliation":[{"name":"Department of Medical Imaging, Tongji Hospital Shanghai Frontiers Science Center of Nanocatalytic Medicine the Institute for Biomedical Engineering &amp; Nano Science School of Medicine Tongji University  Shanghai China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gongyao","family":"Yu","sequence":"additional","affiliation":[{"name":"Department of Medical Imaging, Tongji Hospital Shanghai Frontiers Science Center of Nanocatalytic Medicine the Institute for Biomedical Engineering &amp; Nano Science School of Medicine Tongji University  Shanghai China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yanjing","family":"Yun","sequence":"additional","affiliation":[{"name":"Shanghai Research Institute for Intelligent Autonomous Systems Tongji University  Shanghai China"},{"name":"Department of Medical Imaging, Tongji Hospital Shanghai Frontiers Science Center of Nanocatalytic Medicine the Institute for Biomedical Engineering &amp; Nano Science School of Medicine Tongji University  Shanghai China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kexin","family":"Bian","sequence":"additional","affiliation":[{"name":"Department of Medical Imaging, Tongji Hospital Shanghai Frontiers Science Center of Nanocatalytic Medicine the Institute for Biomedical Engineering &amp; Nano Science School of Medicine Tongji University  Shanghai China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shuang","family":"Wu","sequence":"additional","affiliation":[{"name":"Department of Medical Imaging, Tongji Hospital Shanghai Frontiers Science Center of Nanocatalytic Medicine the Institute for Biomedical Engineering &amp; Nano Science School of Medicine Tongji University  Shanghai China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hui","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Medical Imaging, Tongji Hospital Shanghai Frontiers Science Center of Nanocatalytic Medicine the Institute for Biomedical Engineering &amp; Nano Science School of Medicine Tongji University  Shanghai China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chang","family":"Liu","sequence":"additional","affiliation":[{"name":"Department of Medical Imaging, Tongji Hospital Shanghai Frontiers Science Center of Nanocatalytic Medicine the Institute for Biomedical Engineering &amp; Nano Science School of Medicine Tongji University  Shanghai China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hao","family":"Wang","sequence":"additional","affiliation":[{"name":"Shanghai Chenguang Medical Technology Co., Ltd.  Shanghai China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9216-025X","authenticated-orcid":false,"given":"Pu\u2010Yeh","family":"Wu","sequence":"additional","affiliation":[{"name":"GE Healthcare  Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qiong\u2010Lan","family":"Yuan","sequence":"additional","affiliation":[{"name":"Shanghai Research Institute for Intelligent Autonomous Systems Tongji University  Shanghai China"},{"name":"Department of Neurology Department of Human Anatomy School of Medicine Shanghai Tongji Hospital Histology &amp; Embryology Tongji University  Shanghai China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0981-7071","authenticated-orcid":false,"given":"Bingbo","family":"Zhang","sequence":"additional","affiliation":[{"name":"Shanghai Research Institute for Intelligent Autonomous Systems Tongji University  Shanghai China"},{"name":"Department of Medical Imaging, Tongji Hospital Shanghai Frontiers Science Center of Nanocatalytic Medicine the Institute for Biomedical Engineering &amp; Nano Science School of Medicine Tongji University  Shanghai China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,9,8]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1002\/cncr.35444"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1148\/rg.220087"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00330\u2010004\u20102236\u20101"},{"key":"e_1_2_8_5_1","doi-asserted-by":"crossref","first-page":"421","DOI":"10.1016\/j.jhep.2012.01.031","article-title":"Primovist, Eovist: What to Expect?","volume":"57","author":"Van Beers B. 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