{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,8]],"date-time":"2026-09-08T09:11:01Z","timestamp":1788858661280,"version":"build-2803163510"},"reference-count":62,"publisher":"Wiley","license":[{"start":{"date-parts":[[2026,9,8]],"date-time":"2026-09-08T00:00:00Z","timestamp":1788825600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2026,9,8]],"date-time":"2026-09-08T00:00:00Z","timestamp":1788825600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["32171314"],"award-info":[{"award-number":["32171314"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Small"],"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>\n                    Osteolytic bone metastasis remains difficult to treat because effective tumor eradication and bone regeneration must be achieved simultaneously. Current calcification\u2010based strategies are constrained by their reliance on exogenous phosphate, and poor integration with controllable therapeutic modalities. Herein, we report a tumor adhesive metal\u2010phenolic network nanoplatform that enables phosphate\u2010independent membrane biomineralization combined with photothermal amplification. The Ru\/Ca\u2010TA\u2010ALN network, assembled from ruthenium ions (Ru\n                    <jats:sup>3+<\/jats:sup>\n                    ), calcium ions (Ca\n                    <jats:sup>2+<\/jats:sup>\n                    ), tannic acid (TA), and alendronate (ALN), co\u2010integrates Ca\n                    <jats:sup>2+<\/jats:sup>\n                    and phosphate\u2010bearing moieties within a single coordination framework, allowing autonomous mineral deposition upon adhesion to tumor cell membranes. This membrane\u2010confined calcified interface induced S\u2010phase arrest, and impaired tumor viability. Under 1064\u00a0nm near\u2010infrared (NIR) irradiation, Ru\n                    <jats:sup>3+<\/jats:sup>\n                    \u2010mediated photothermal activation amplifies tumor cell apoptosis. Beyond tumor inhibition, the calcified nano\u2010bio interface promoted osteogenic differentiation while suppressing osteoclastogenesis, shifting the bone microenvironment toward regeneration. In a murine breast cancer bone metastasis model, calcification\u2010photothermal synergy significantly reduced tumor burden, mitigated bone destruction, and prolonged survival, while maintaining favorable biocompatibility. By transforming biomineralization into a controllable interfacial therapeutic modality, this work establishes a strategy that couples tumor suppression with bone reconstruction for metastatic bone disease.\n                  <\/jats:p>","DOI":"10.1002\/smll.75689","type":"journal-article","created":{"date-parts":[[2026,9,8]],"date-time":"2026-09-08T08:45:11Z","timestamp":1788857111000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Tumor\u2010Adhesive Ru\/Ca\u2010Tannic Acid Network Enables Phosphate\u2010Independent Calcification and Photothermal\u2010Synergistic Therapy for Osteolytic Bone Metastasis"],"prefix":"10.1002","author":[{"given":"Xinyi","family":"Li","sequence":"first","affiliation":[{"name":"School of Biomedical and Pharmaceutical Sciences Guangdong University of Technology  Guangzhou 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