{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,11]],"date-time":"2026-09-11T07:07:20Z","timestamp":1789110440369,"version":"build-2803163510"},"reference-count":39,"publisher":"Wiley","license":[{"start":{"date-parts":[[2026,9,10]],"date-time":"2026-09-10T00:00:00Z","timestamp":1788998400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2026,9,10]],"date-time":"2026-09-10T00:00:00Z","timestamp":1788998400000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["32371407"],"award-info":[{"award-number":["32371407"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["22072060"],"award-info":[{"award-number":["22072060"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82160421"],"award-info":[{"award-number":["82160421"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Small"],"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>Nasal mucus acts as a primary immunological barrier by synergistically integrating physical trapping and chemical antimicrobial defenses. However, constructing an artificial gel system that recapitulates this multifunctionality for catalytic antibacterial therapy remains challenging. Here, we report a mucus\u2010inspired catalytic hydrogel that incorporates lysozyme nanofiber\u2013templated PtCu nanohybrids into a thermoresponsive PEO\u2013PPO\u2013PEO triblock copolymer matrix. The resulting hydrogel exhibits excellent biocompatibility, robust peroxidase\u2010like catalytic activity, NIR\u2010responsive photothermal effects, and strong adaptability to heterogeneous wound microenvironments. By confining enzyme mimics at infection sites, the hydrogel enables sustained catalytic antibacterial action while buffering bacterial toxins, thereby mitigating inflammatory injury and preserving a regenerative microenvironment. This biomimetic system synergistically combines physical bacterial trapping with chemical catalytic killing, effectively eradicating both superficial infections and deep\u2010seated periprosthetic joint infections. Moreover, it promotes wound healing, enhances osteogenesis, and suppresses pro\u2010inflammatory cytokine expression. This work provides a promising strategy for developing artificial immune systems that emulate or even surpass the functional sophistication of natural mucus barriers.<\/jats:p>","DOI":"10.1002\/smll.75710","type":"journal-article","created":{"date-parts":[[2026,9,11]],"date-time":"2026-09-11T06:35:47Z","timestamp":1789108547000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["A Biomimetic Nasal Mucus Gel System Adaptable for Catalytic Antibacterial Therapy"],"prefix":"10.1002","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-5794-5871","authenticated-orcid":false,"given":"Yonghai","family":"Feng","sequence":"first","affiliation":[{"name":"Institute for Advanced Materials School of Materials Science and Engineering Jiangsu University  Zhenjiang China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fang","family":"Yang","sequence":"additional","affiliation":[{"name":"Institute for Advanced Materials School of Materials Science and Engineering Jiangsu University  Zhenjiang China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Guangzhao","family":"Zhu","sequence":"additional","affiliation":[{"name":"Department of Orthopaedics First Affiliated Hospital of Xinjiang Medical University  Urumqi Xinjiang China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaogang","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of Orthopaedics First Affiliated Hospital of Xinjiang Medical University  Urumqi Xinjiang China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5256-9301","authenticated-orcid":false,"given":"Xiaobin","family":"Guo","sequence":"additional","affiliation":[{"name":"Department of Orthopaedics First Affiliated Hospital of Xinjiang Medical University  Urumqi Xinjiang China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0001-0214-4046","authenticated-orcid":false,"given":"Yangyang","family":"Wan","sequence":"additional","affiliation":[{"name":"Institute for Advanced Materials School of Materials Science and Engineering Jiangsu University  Zhenjiang China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6265-9412","authenticated-orcid":false,"given":"Lei","family":"Liu","sequence":"additional","affiliation":[{"name":"Institute for Advanced Materials School of Materials Science and Engineering Jiangsu University  Zhenjiang China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,9,10]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrmicro.2017.42"},{"key":"e_1_2_9_3_1","doi-asserted-by":"crossref","first-page":"2153","DOI":"10.1038\/s41564-025-02061-0","article-title":"Deep Learning Reveals Antibiotics in the Archaeal Proteome","volume":"6","author":"Torres M. D.","year":"2025","journal-title":"Nature Microbiology"},{"key":"e_1_2_9_4_1","doi-asserted-by":"crossref","DOI":"10.3389\/fsufs.2022.1043823","article-title":"Evaluation of the Antimicrobial Effects of Capsicum, Nigella sativa, Musa paradisiaca L., and Citrus limetta: A Review","volume":"6","author":"Bhatti S. A.","year":"2022","journal-title":"Frontiers in Sustainable Food Systems"},{"key":"e_1_2_9_5_1","doi-asserted-by":"crossref","DOI":"10.1016\/j.lwt.2021.112427","article-title":"Antibacterial Efficacy of Satureja montana L. essential Oil Encapsulated in Methyl\u2010\u03b2\u2010cyclodextrin\/Soy Soluble Polysaccharide Hydrogel and Its Assessment as Meat Preservative","volume":"152","author":"Cui H.","year":"2021","journal-title":"Lwt"},{"key":"e_1_2_9_6_1","doi-asserted-by":"crossref","first-page":"114","DOI":"10.1016\/j.bioactmat.2025.07.009","article-title":"Strategies and Applications of Antibacterial Surface\u2010modified Biomaterials","volume":"53","author":"Su Q.","year":"2025","journal-title":"Bioactive Materials"},{"key":"e_1_2_9_7_1","doi-asserted-by":"crossref","first-page":"436","DOI":"10.1016\/j.bioactmat.2022.09.004","article-title":"Shifting Focus From Bacteria to Host Neutrophil Extracellular Traps of Biodegradable Pure Zn to Combat Implant\u2010Centered Infection","volume":"21","author":"Peng F.","year":"2023","journal-title":"Bioactive Materials"},{"key":"e_1_2_9_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1473\u20103099(01)00094\u20109"},{"key":"e_1_2_9_9_1","doi-asserted-by":"publisher","DOI":"10.1002\/adma.202506119"},{"key":"e_1_2_9_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.indcrop.2021.113441"},{"key":"e_1_2_9_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.fm.2019.103344"},{"key":"e_1_2_9_12_1","doi-asserted-by":"publisher","DOI":"10.1002\/fsn3.70688"},{"key":"e_1_2_9_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jff.2021.104752"},{"key":"e_1_2_9_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.celbio.2025.100217"},{"key":"e_1_2_9_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.celbio.2025.100074"},{"key":"e_1_2_9_16_1","doi-asserted-by":"publisher","DOI":"10.1002\/adma.202308029"},{"key":"e_1_2_9_17_1","doi-asserted-by":"publisher","DOI":"10.1002\/agt2.700"},{"key":"e_1_2_9_18_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2022.11.030"},{"key":"e_1_2_9_19_1","doi-asserted-by":"publisher","DOI":"10.1021\/acs.nanolett.4c03228"},{"key":"e_1_2_9_20_1","doi-asserted-by":"publisher","DOI":"10.3390\/medicina59071259"},{"key":"e_1_2_9_21_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaci.2018.08.046"},{"key":"e_1_2_9_22_1","doi-asserted-by":"publisher","DOI":"10.1038\/35090602"},{"key":"e_1_2_9_23_1","doi-asserted-by":"crossref","first-page":"307","DOI":"10.1016\/j.freeradbiomed.2016.06.026","article-title":"Flavonoids as Promoters of the (pseudo\u2010) Halogenating Activity of Lactoperoxidase and Myeloperoxidase","volume":"97","author":"Gau J.","year":"2016","journal-title":"Free Radical Biology and Medicine"},{"key":"e_1_2_9_24_1","doi-asserted-by":"crossref","DOI":"10.1016\/j.foodchem.2025.144449","article-title":"Facile Fabrication of Surface Imprinted Polymers Based on Nanofibrous Aerogels for Specific Capture of Lysozyme Form Egg White","volume":"484","author":"Qiao Y.","year":"2025","journal-title":"Food Chemistry"},{"key":"e_1_2_9_25_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.2103995118"},{"key":"e_1_2_9_26_1","doi-asserted-by":"publisher","DOI":"10.3390\/pharmaceutics15082102"},{"key":"e_1_2_9_27_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0087681"},{"key":"e_1_2_9_28_1","doi-asserted-by":"crossref","DOI":"10.3389\/fbioe.2022.916354","article-title":"Passive and Active Microrheology for Biomedical Systems","volume":"10","author":"Mao Y.","year":"2022","journal-title":"Frontiers in Bioengineering Biotechnology"},{"key":"e_1_2_9_29_1","doi-asserted-by":"publisher","DOI":"10.1002\/mame.202400356"},{"key":"e_1_2_9_30_1","doi-asserted-by":"publisher","DOI":"10.3390\/polym16233422"},{"key":"e_1_2_9_31_1","doi-asserted-by":"publisher","DOI":"10.1080\/03639045.2023.2291463"},{"key":"e_1_2_9_32_1","doi-asserted-by":"publisher","DOI":"10.1002\/adfm.202110432"},{"key":"e_1_2_9_33_1","doi-asserted-by":"publisher","DOI":"10.1038\/s44222\u2010024\u201000205\u20101"},{"key":"e_1_2_9_34_1","doi-asserted-by":"publisher","DOI":"10.1002\/adfm.202511530"},{"key":"e_1_2_9_35_1","doi-asserted-by":"crossref","first-page":"0710","DOI":"10.34133\/research.0710","article-title":"Nitrite Reductases in Biomedicine: From Natural Enzymes to Artificial Mimics","volume":"8","author":"Zhu S.","year":"2025","journal-title":"Research"},{"key":"e_1_2_9_36_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41467\u2010023\u201044463\u2010w"},{"key":"e_1_2_9_37_1","doi-asserted-by":"publisher","DOI":"10.1126\/sciadv.adp5935"},{"key":"e_1_2_9_38_1","doi-asserted-by":"crossref","DOI":"10.1016\/j.mtbio.2023.100730","article-title":"Amyloid\u2010Like Nanofibrous Network Confined and Aligned Ultrafine Bimetallic Nanozymes for Smart Antibacterial Therapy","volume":"22","author":"Feng Y.","year":"2023","journal-title":"Materials Today Bio"},{"issue":"3","key":"e_1_2_9_39_1","doi-asserted-by":"crossref","first-page":"265","DOI":"10.1016\/S0927-7765(01)00278-8","article-title":"Comparison of Adsorption Performances of Metal\u2013Chelated Polyamide Hollow Fibre Membranes in Lysozyme Separation","volume":"24","author":"\u015eenel S.","year":"2002","journal-title":"Colloids and Surfaces B"},{"key":"e_1_2_9_40_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.colsurfa.2005.07.029"}],"container-title":["Small"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/smll.75710","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1002\/smll.75710","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/smll.75710","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,9,11]],"date-time":"2026-09-11T06:35:50Z","timestamp":1789108550000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/smll.75710"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,9,10]]},"references-count":39,"alternative-id":["10.1002\/smll.75710"],"URL":"https:\/\/doi.org\/10.1002\/smll.75710","archive":["Portico"],"relation":{},"ISSN":["1613-6810","1613-6829"],"issn-type":[{"value":"1613-6810","type":"print"},{"value":"1613-6829","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,9,10]]},"assertion":[{"value":"2026-02-25","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-09-01","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-09-10","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e75710"}}