{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,12]],"date-time":"2026-09-12T07:12:35Z","timestamp":1789197155131,"version":"build-2803163510"},"reference-count":82,"publisher":"Wiley","license":[{"start":{"date-parts":[[2026,9,11]],"date-time":"2026-09-11T00:00:00Z","timestamp":1789084800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2026,9,11]],"date-time":"2026-09-11T00:00:00Z","timestamp":1789084800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["32372274"],"award-info":[{"award-number":["32372274"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Small"],"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>Here we report a fuel\u2010free, all\u2010optical platform that overcomes key limitations of conventional thrombolysis and offers a promising strategy for targeted, combined thrombolytic\u2010anticoagulant vascular therapy based on food\u2010derived bioactive substances. Thrombotic diseases remain difficult to treat because mature fibrin\u2010rich clots restrict drug penetration, while systemic thrombolytics carry substantial bleeding risks. To address these challenges, we developed a near\u2010infrared (NIR)\u2010propelled biomimetic nanomotor (NM) loaded with a food\u2010derived antithrombotic peptide to achieve integrated thrombolytic and anticoagulant therapy. The NM consists of a mesoporous silica core co\u2010loaded with this food\u2010derived antithrombotic peptide and a heat\u2010labile nitric oxide donor, decorated with photothermal platinum nanoparticles, and cloaked with a natural platelet membrane for active targeting. Under 808 nm NIR irradiation, the NM generates a localized temperature gradient that drives self\u2010thermophoretic motion to improve interaction with fibrin networks. Simultaneously, the photothermal effect facilitates the release of both therapeutic agents at the thrombus site. In vitro and in vivo evaluations demonstrated rapid clot dissolution (&gt;93.5% lysis in vitro, 94.2% blood flow recovery in vivo) without inducing hemolysis or systemic bleeding.<\/jats:p>","DOI":"10.1002\/smll.75718","type":"journal-article","created":{"date-parts":[[2026,9,12]],"date-time":"2026-09-12T06:50:22Z","timestamp":1789195822000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Biomimetic Silica Nanomotors Loaded with Food\u2010Derived Antithrombotic Peptides for NIR Photothermal Efficient Clot Thrombolysis\u2010Anticoagulation"],"prefix":"10.1002","author":[{"given":"Huizhen","family":"Xing","sequence":"first","affiliation":[{"name":"College of Food Science and Engineering, Key Laboratory of Grains and Oils Quality Control and Processing, Collaborative lnnovation Center for lodern Grain Circulation and Safety Nanjing University of Finance and Economics  Nanjing People's Republic of China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Huimin","family":"Dong","sequence":"additional","affiliation":[{"name":"College of Food Science and Engineering, Key Laboratory of Grains and Oils Quality Control and Processing, Collaborative lnnovation Center for lodern Grain Circulation and Safety Nanjing University of Finance and Economics  Nanjing People's Republic of China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chengzhi","family":"Guo","sequence":"additional","affiliation":[{"name":"College of Food Science and Engineering, Key Laboratory of Grains and Oils Quality Control and Processing, Collaborative lnnovation Center for lodern Grain Circulation and Safety Nanjing University of Finance and Economics  Nanjing People's Republic of China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhigao","family":"Wang","sequence":"additional","affiliation":[{"name":"College of Food Science and Engineering, Key Laboratory of Grains and Oils Quality Control and Processing, Collaborative lnnovation Center for lodern Grain Circulation and Safety Nanjing University of Finance and Economics  Nanjing People's Republic of China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9401-6059","authenticated-orcid":false,"given":"Yucheng","family":"Zou","sequence":"additional","affiliation":[{"name":"School of Food and Biological Engineering Jiangsu University  Zhenjiang Jiangsu People's Republic of China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8707-172X","authenticated-orcid":false,"given":"Xingyun","family":"Wang","sequence":"additional","affiliation":[{"name":"Guangzhou Institute of Pediatrics, Guangzhou Women and Children's Medical Center Guangzhou Medical University  Guangzhou Guangdong People's Republic of China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3341-9786","authenticated-orcid":false,"given":"Rong","family":"He","sequence":"additional","affiliation":[{"name":"College of Food Science and Engineering, Key Laboratory of Grains and Oils Quality Control and Processing, Collaborative lnnovation Center for lodern Grain Circulation and Safety Nanjing University of Finance and Economics  Nanjing People's Republic of China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,9,11]]},"reference":[{"issue":"10","key":"e_1_2_7_2_1","doi-asserted-by":"crossref","first-page":"989","DOI":"10.3390\/brainsci14100989","article-title":"Intravenous Thrombolysis with Urokinase for Acute Ischemic Stroke","volume":"14","author":"Qiao Y.","year":"2024","journal-title":"Brain 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