{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,24]],"date-time":"2026-09-24T16:07:21Z","timestamp":1790266041724,"version":"4.1.0"},"reference-count":72,"publisher":"Wiley","license":[{"start":{"date-parts":[[2026,9,24]],"date-time":"2026-09-24T00:00:00Z","timestamp":1790208000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2026,9,24]],"date-time":"2026-09-24T00:00:00Z","timestamp":1790208000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/501100006407","name":"Natural Science Foundation of Henan Province","doi-asserted-by":"publisher","award":["222300420533"],"award-info":[{"award-number":["222300420533"]}],"id":[{"id":"10.13039\/501100006407","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100006407","name":"Natural Science Foundation of Henan Province","doi-asserted-by":"publisher","award":["222300420283"],"award-info":[{"award-number":["222300420283"]}],"id":[{"id":"10.13039\/501100006407","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82504236"],"award-info":[{"award-number":["82504236"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Small"],"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>\n                    Downregulating oncogenic microRNAs (miRNAs) is an attractive strategy for reversing drug resistance in cancer therapy. Compared to antisense, DNAzyme (Dz) possesses advantages such as recyclability and stability. However, it still suffers from insufficient stability and inadequate endogenous cofactors. Herein, by using miRNA\u201021 (miR\u201021) as target, MCF\u20107\/ADR as tumor model, a multi\u2010modality, polyvalent, Spherical Nucleic Acids (SNAs)\u2010type drug delivery system (DDS) was developed. A Y\u2010DNA nanoassembly was synthesized, and directional immobilized on polydopamine@MnO\n                    <jats:sub>2<\/jats:sub>\n                    (PDM) nanoparticles. The Y\u2010DNA contains two Dz sequences for cleaving miR\u201021, and a tumor\u2010targeting aptamer. Doxorubicin was loaded at a loading rate of 23.33%. The DDS dramatically improved the Dz stability, self\u2010supplied cofactors, efficiently targeted tumor tissues and cells. Additionally, it relieved hypoxia, depleted glutathione, generated reaction oxygen species, and transferred near\u2010infrared light to heat. Consequently, highly responsive, and DNase resistant cleavage of miR\u201021 was realized. Intracellular miR\u201021 was efficiently downregulated. Doxorubicin was controllably and efficiently released. With the PDM@Y\u2010DNA@D (Laser+) treatment, the cancer cell viability lowered to \u22643%, and tumor growth inhibition reached to 86%. Molecular mechanisms involved in the drug resistance reversal were investigated. The DDS provides a promisingly transformable therapeutic platform for drug resistant cancers, and for targeting other and multiple oncogenic miRNAs.\n                  <\/jats:p>","DOI":"10.1002\/smll.75736","type":"journal-article","created":{"date-parts":[[2026,9,24]],"date-time":"2026-09-24T15:23:48Z","timestamp":1790263428000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["DNA Nanoassembly Modified Polydopamine@MnO\n                    <sub>2<\/sub>\n                    Nanoparticles: Enhancement of miRNA\u201021 Downregulation for Reversal of Breast Cancer Drug\u2010Resistance"],"prefix":"10.1002","author":[{"given":"Qian","family":"Guo","sequence":"first","affiliation":[{"name":"School of Life Sciences Zhengzhou University  Zhengzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0001-0483-5975","authenticated-orcid":false,"given":"Junyang","family":"Chen","sequence":"additional","affiliation":[{"name":"School of Life Sciences Zhengzhou University  Zhengzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yu\u2010Lu","family":"Wang","sequence":"additional","affiliation":[{"name":"School of Life Sciences Zhengzhou University  Zhengzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qi\u2010Yan","family":"Lv","sequence":"additional","affiliation":[{"name":"School of Life Sciences Zhengzhou University  Zhengzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiao\u2010Qing","family":"Ling","sequence":"additional","affiliation":[{"name":"School of Life Sciences Zhengzhou University  Zhengzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2988-2209","authenticated-orcid":false,"given":"Xiaojie","family":"Song","sequence":"additional","affiliation":[{"name":"School of Life Sciences Zhengzhou University  Zhengzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7270-4491","authenticated-orcid":false,"given":"Hui\u2010Fang","family":"Cui","sequence":"additional","affiliation":[{"name":"School of Life Sciences Zhengzhou University  Zhengzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,9,24]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1300\/J013v26n01_01"},{"key":"e_1_2_8_3_1","doi-asserted-by":"crossref","first-page":"88","DOI":"10.1007\/s12032-023-01954-6","article-title":"Chemotherapy: How to Reduce Its Adverse Effects While Maintaining the Potency?","volume":"40","author":"Brianna S. H. L.","year":"2023","journal-title":"Medical Oncology"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.3390\/ijms21093233"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.canlet.2014.03.013"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.canlet.2015.10.010"},{"key":"e_1_2_8_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.drup.2020.100682"},{"key":"e_1_2_8_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.biopha.2018.03.088"},{"key":"e_1_2_8_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.arcmed.2011.06.008"},{"key":"e_1_2_8_10_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.0510565103"},{"key":"e_1_2_8_11_1","doi-asserted-by":"publisher","DOI":"10.1109\/TIM.2019.2911756"},{"key":"e_1_2_8_12_1","doi-asserted-by":"publisher","DOI":"10.2147\/IJGM.S275016"},{"key":"e_1_2_8_13_1","doi-asserted-by":"publisher","DOI":"10.1159\/000488831"},{"key":"e_1_2_8_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.abb.2018.10.021"},{"key":"e_1_2_8_15_1","doi-asserted-by":"publisher","DOI":"10.3390\/molecules24132489"},{"key":"e_1_2_8_16_1","doi-asserted-by":"publisher","DOI":"10.2147\/IJN.S122171"},{"key":"e_1_2_8_17_1","doi-asserted-by":"publisher","DOI":"10.1158\/1535\u20107163.MCT\u201008\u20100021"},{"key":"e_1_2_8_18_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.94.9.4262"},{"key":"e_1_2_8_19_1","doi-asserted-by":"publisher","DOI":"10.1038\/srep24516"},{"key":"e_1_2_8_20_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.tibs.2016.04.010"},{"key":"e_1_2_8_21_1","doi-asserted-by":"publisher","DOI":"10.1021\/jacs.5c11409"},{"key":"e_1_2_8_22_1","doi-asserted-by":"publisher","DOI":"10.1002\/anie.201411417"},{"key":"e_1_2_8_23_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ccr.2022.214651"},{"key":"e_1_2_8_24_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1582\u20104934.2009.00994.x"},{"key":"e_1_2_8_25_1","doi-asserted-by":"publisher","DOI":"10.3390\/cells9122628"},{"key":"e_1_2_8_26_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0043726"},{"key":"e_1_2_8_27_1","doi-asserted-by":"publisher","DOI":"10.4161\/cbt.12.10.17681"},{"key":"e_1_2_8_28_1","doi-asserted-by":"publisher","DOI":"10.1021\/acsnano.5c17672"},{"key":"e_1_2_8_29_1","doi-asserted-by":"publisher","DOI":"10.1002\/adfm.202503885"},{"key":"e_1_2_8_30_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12951\u2010025\u201003531\u20107"},{"key":"e_1_2_8_31_1","doi-asserted-by":"publisher","DOI":"10.1002\/agt2.652"},{"key":"e_1_2_8_32_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12951\u2010022\u201001701\u20105"},{"key":"e_1_2_8_33_1","doi-asserted-by":"publisher","DOI":"10.1021\/acs.analchem.5c03309"},{"key":"e_1_2_8_34_1","doi-asserted-by":"publisher","DOI":"10.1002\/anie.202410353"},{"key":"e_1_2_8_35_1","doi-asserted-by":"publisher","DOI":"10.1021\/nl802958f"},{"key":"e_1_2_8_36_1","doi-asserted-by":"publisher","DOI":"10.1093\/nar\/gkn967"},{"key":"e_1_2_8_37_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cej.2022.138138"},{"key":"e_1_2_8_38_1","doi-asserted-by":"publisher","DOI":"10.1021\/acs.nanolett.1c01727"},{"key":"e_1_2_8_39_1","doi-asserted-by":"publisher","DOI":"10.1021\/nn405773r"},{"key":"e_1_2_8_40_1","doi-asserted-by":"publisher","DOI":"10.1021\/acsami.6b15247"},{"key":"e_1_2_8_41_1","doi-asserted-by":"publisher","DOI":"10.1002\/anie.201712027"},{"key":"e_1_2_8_42_1","doi-asserted-by":"publisher","DOI":"10.1002\/adma.201204683"},{"key":"e_1_2_8_43_1","doi-asserted-by":"publisher","DOI":"10.1039\/c9tb02002k"},{"key":"e_1_2_8_44_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.colsurfb.2025.114748"},{"key":"e_1_2_8_45_1","doi-asserted-by":"publisher","DOI":"10.1021\/ac504206n"},{"key":"e_1_2_8_46_1","doi-asserted-by":"publisher","DOI":"10.1039\/d0nr08845e"},{"key":"e_1_2_8_47_1","doi-asserted-by":"publisher","DOI":"10.1021\/acs.langmuir.7b03797"},{"key":"e_1_2_8_48_1","doi-asserted-by":"publisher","DOI":"10.1002\/adtp.202200108"},{"key":"e_1_2_8_49_1","doi-asserted-by":"publisher","DOI":"10.1021\/acsabm.3c00544"},{"key":"e_1_2_8_50_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.colsurfa.2022.130495"},{"key":"e_1_2_8_51_1","doi-asserted-by":"publisher","DOI":"10.1095\/biolreprod.102.012435"},{"key":"e_1_2_8_52_1","doi-asserted-by":"publisher","DOI":"10.3233\/CBM\u2010170967"},{"key":"e_1_2_8_53_1","doi-asserted-by":"publisher","DOI":"10.1080\/17425247.2019.1575808"},{"key":"e_1_2_8_54_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijpharm.2019.118483"},{"key":"e_1_2_8_55_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijpharm.2019.118483"},{"key":"e_1_2_8_56_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.biomaterials.2020.120649"},{"key":"e_1_2_8_57_1","doi-asserted-by":"publisher","DOI":"10.1155\/2013\/972913"},{"key":"e_1_2_8_58_1","doi-asserted-by":"publisher","DOI":"10.1002\/ijc.11260"},{"key":"e_1_2_8_59_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.arbres.2023.07.001"},{"key":"e_1_2_8_60_1","doi-asserted-by":"publisher","DOI":"10.3892\/or.2017.5717"},{"key":"e_1_2_8_61_1","doi-asserted-by":"publisher","DOI":"10.3390\/cancers11081076"},{"key":"e_1_2_8_62_1","doi-asserted-by":"publisher","DOI":"10.3390\/cells7070064"},{"key":"e_1_2_8_63_1","doi-asserted-by":"publisher","DOI":"10.1002\/ijc.20596"},{"key":"e_1_2_8_64_1","doi-asserted-by":"publisher","DOI":"10.1186\/s13046\u2010016\u20100399\u20107"},{"key":"e_1_2_8_65_1","doi-asserted-by":"publisher","DOI":"10.3892\/mmr.2016.5010"},{"key":"e_1_2_8_66_1","doi-asserted-by":"publisher","DOI":"10.1007\/s13277\u2010016\u20105073\u20103"},{"key":"e_1_2_8_67_1","doi-asserted-by":"publisher","DOI":"10.1038\/sj.emboj.7601727"},{"key":"e_1_2_8_68_1","doi-asserted-by":"publisher","DOI":"10.1021\/acs.molpharmaceut.8b01298"},{"key":"e_1_2_8_69_1","doi-asserted-by":"publisher","DOI":"10.2174\/1871520615666150129212723"},{"key":"e_1_2_8_70_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0360\u20103016(02)02848\u20101"},{"key":"e_1_2_8_71_1","doi-asserted-by":"publisher","DOI":"10.3389\/fonc.2022.964934"},{"key":"e_1_2_8_72_1","doi-asserted-by":"publisher","DOI":"10.3390\/ijms18091851"},{"key":"e_1_2_8_73_1","doi-asserted-by":"publisher","DOI":"10.1039\/d0ay01878c"}],"container-title":["Small"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/smll.75736","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1002\/smll.75736","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/smll.75736","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,9,24]],"date-time":"2026-09-24T15:23:49Z","timestamp":1790263429000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/smll.75736"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,9,24]]},"references-count":72,"alternative-id":["10.1002\/smll.75736"],"URL":"https:\/\/doi.org\/10.1002\/smll.75736","archive":["Portico"],"relation":{},"ISSN":["1613-6810","1613-6829"],"issn-type":[{"value":"1613-6810","type":"print"},{"value":"1613-6829","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,9,24]]},"assertion":[{"value":"2026-01-05","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-09-03","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-09-24","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e75736"}}