{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,10]],"date-time":"2026-09-10T11:10:15Z","timestamp":1789038615718,"version":"build-2803163510"},"reference-count":16,"publisher":"Wiley","license":[{"start":{"date-parts":[[2026,9,10]],"date-time":"2026-09-10T00:00:00Z","timestamp":1788998400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2026,9,10]],"date-time":"2026-09-10T00:00:00Z","timestamp":1788998400000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Small"],"abstract":"ABSTRACT<\/jats:title>\n \n The low utilization efficiency of nitrogen fertilizers poses significant economic and environmental challenges. To address this issue, the development of dual\u2010functional inhibitors capable of simultaneously delaying urea hydrolysis and nitrification is highly desirable. In this study, two new copper\u2010based coordination polymers, [Cu\n 2<\/jats:sub>\n (3\u2010padpe)\n 2<\/jats:sub>\n (5\u2010MIP)\n 2<\/jats:sub>\n (H\n 2<\/jats:sub>\n O)\n 2<\/jats:sub>\n ]\n n<\/jats:sub>\n (\n Cu\u2010CP\u20101<\/jats:bold>\n ) and {[Cu(3\u2010padpe)(2,5\u2010tdca)(H\n 2<\/jats:sub>\n O)]\u00b7H\n 2<\/jats:sub>\n O}\n n<\/jats:sub>\n (\n Cu\u2010CP\u20102<\/jats:bold>\n ), were rationally designed and synthesized via hydrothermal methods. Both compounds exhibited potent urease inhibitory activity with IC\n 50<\/jats:sub>\n values of 3.40 \u00b1 0.01 \u00b5M and 9.15 \u00b1 0.04 \u00b5M, respectively, significantly surpassing their organic ligands and reference inhibitors. Kinetic and molecular docking studies revealed that they act as uncompetitive inhibitors, binding to the enzyme\u2010substrate complex through multiple hydrogen bonds and hydrophobic interactions. Soil incubation experiments demonstrated that\n Cu\u2010CP\u20101<\/jats:bold>\n and\n Cu\u2010CP\u20102<\/jats:bold>\n significantly prolonged NH\n 4<\/jats:sub>\n +<\/jats:sup>\n \u2010N retention and reduced NO\n 3<\/jats:sub>\n \u2212<\/jats:sup>\n \u2010N and NO\n 2<\/jats:sub>\n \u2212<\/jats:sup>\n \u2010N accumulation compared to the control, suggesting a potential for improving nitrogen availability in soil. This work presents two promising candidates for nitrogen management and provides a foundation for future studies on structure\u2010guided design of multifunctional agrochemical materials.\n <\/jats:p>","DOI":"10.1002\/smll.75747","type":"journal-article","created":{"date-parts":[[2026,9,10]],"date-time":"2026-09-10T10:34:48Z","timestamp":1789036488000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Rational Design and Evaluation of Two Novel Copper\u2010Based Coordination Polymers as High\u2010Performance Dual\u2010Functional Inhibitors for Enhanced Nitrogen Use Efficiency in Agriculture"],"prefix":"10.1002","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-3851-0829","authenticated-orcid":false,"given":"Jian","family":"Luan","sequence":"first","affiliation":[{"name":"College of Science Shenyang University of Chemical Technology Shenyang People's Republic of China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Si\u2010Qi","family":"Wang","sequence":"additional","affiliation":[{"name":"College of Science Shenyang University of Chemical Technology Shenyang People's Republic of China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhen\u2010Xue","family":"He","sequence":"additional","affiliation":[{"name":"Guizhou Tianbaofeng Original Ecological Agriculture Technology Co., Ltd. Guiyang People's Republic of China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nan","family":"Su","sequence":"additional","affiliation":[{"name":"College of Science Shenyang University of Chemical Technology Shenyang People's Republic of China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0002-0732-9813","authenticated-orcid":false,"given":"Wen\u2010Ze","family":"Li","sequence":"additional","affiliation":[{"name":"College of Science Shenyang University of Chemical Technology Shenyang People's Republic of China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zong\u2010Yun","family":"Lu","sequence":"additional","affiliation":[{"name":"Guizhou Tianbaofeng Original Ecological Agriculture Technology Co., Ltd. Guiyang People's Republic of China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wen\u2010Long","family":"Duan","sequence":"additional","affiliation":[{"name":"College of Science Shenyang University of Chemical Technology Shenyang People's Republic of China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,9,10]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1002\/adfm.202500944"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.soilbio.2025.110000"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1021\/acs.jafc.4c07972"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ecoenv.2021.112338"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.7668\/hbnxb.2017.S1.051"},{"key":"e_1_2_8_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ica.2022.121184"},{"key":"e_1_2_8_8_1","doi-asserted-by":"publisher","DOI":"10.1039\/D3DT01375H"},{"key":"e_1_2_8_9_1","doi-asserted-by":"publisher","DOI":"10.1002\/adfm.202425522"},{"key":"e_1_2_8_10_1","doi-asserted-by":"publisher","DOI":"10.1021\/acsami.5c16933"},{"key":"e_1_2_8_11_1","doi-asserted-by":"publisher","DOI":"10.1021\/acsami.5c12805"},{"key":"e_1_2_8_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cclet.2024.109716"},{"key":"e_1_2_8_13_1","doi-asserted-by":"publisher","DOI":"10.1002\/smll.202500706"},{"key":"e_1_2_8_14_1","doi-asserted-by":"publisher","DOI":"10.1021\/acs.inorgchem.6b01157"},{"key":"e_1_2_8_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jinorgbio.2025.113187"},{"key":"e_1_2_8_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bioorg.2025.109086"},{"key":"e_1_2_8_17_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ecoenv.2022.113323"}],"container-title":["Small"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/smll.75747","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1002\/smll.75747","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/smll.75747","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,9,10]],"date-time":"2026-09-10T10:34:50Z","timestamp":1789036490000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/smll.75747"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,9,10]]},"references-count":16,"alternative-id":["10.1002\/smll.75747"],"URL":"https:\/\/doi.org\/10.1002\/smll.75747","archive":["Portico"],"relation":{},"ISSN":["1613-6810","1613-6829"],"issn-type":[{"value":"1613-6810","type":"print"},{"value":"1613-6829","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,9,10]]},"assertion":[{"value":"2026-02-03","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-09-05","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-09-10","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e75747"}}