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Here, we develop a flexible microsensor that achieves self\u2010compensated quad\u2011functional sensing of strain, pressure, liquid\u2010state water molecules, and proximity within an effective compact footprint of 9\u00a0mm\u00a0\u00d7\u00a010\u00a0mm. Through spatial structural isolation, functional unit multiplexing, and a synergistic strategy of multi\u2011valued mapping analysis, the sensor enables independent signal readout and crosstalk compensation under concurrent mechanical and moisture stimuli. Under simultaneous stretching and compression, anisotropic deformations driven by the Poisson effect establish a one\u2011to\u2011one multi\u2011valued mapping with planar and parallel\u2011plate capacitance values, allowing determination of strain and pressure. The exceptional phase\u2011selective hydrophilicity of silk\u2011fibroin and distinct dielectric responses of functional materials reduce interference between liquid\u2010state water\u2010molecule sensing and mechanical sensing. As proof\u2011of\u2011concept applications, we demonstrate mute communication encoding via motion recognition and an AI\u2011driven respiratory monitor that achieves high accuracy in keyword recognition. This work establishes a scalable design paradigm for multifunction independent flexible microsensors, offering a promising pathway toward next\u2011generation wearable electronics and intelligent human\u2010machine interactions.<\/jats:p>","DOI":"10.1002\/smll.75760","type":"journal-article","created":{"date-parts":[[2026,10,9]],"date-time":"2026-10-09T12:50:34Z","timestamp":1791550234000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Self\u2010Compensated Quad\u2010Functional Microsensor for Human\u2010Machine Multi\u2010Dimensional Interaction"],"prefix":"10.1002","author":[{"ORCID":"https:\/\/orcid.org\/0009-0002-2498-6233","authenticated-orcid":false,"given":"Hao","family":"Zheng","sequence":"first","affiliation":[{"name":"School of Integrated Circuit Science and Engineering University of Electronic Science and Technology of China  Chengdu China"},{"name":"State Key Laboratory of Electronic Thin Films and 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