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However, this regenerative transition remains incomplete in intrauterine adhesions, suggesting that insufficient metabolic support may represent an underappreciated barrier to functional repair. Here, we show that an inflammation\u2010homing biomimetic nanoplatform enables preferential NMN delivery to the injured uterus, restoring mitochondrial membrane potential, the NAD\n                    <jats:sup>+<\/jats:sup>\n                    \/NADH ratio, and ATP production in metabolically compromised epithelial cells. Treatment was associated with epithelial proliferation, angiogenic responses, reduced myofibroblast activation, and decreased collagen accumulation. Transcriptomic profiling revealed broad changes from inflammation\u2010 and fibrosis\u2010associated signaling toward a more regeneration\u2010permissive state. In a murine model, treatment increased endometrial thickness, gland number, and vascular density, reduced fibrosis, and improved embryo implantation and live\u2010birth outcomes; pup body weight at postnatal day 12 did not differ detectably among groups. These findings support spatially controlled NAD\n                    <jats:sup>+<\/jats:sup>\n                    delivery as a promising metabolism\u2010oriented strategy for endometrial regeneration.\n                  <\/jats:p>","DOI":"10.1002\/smll.75782","type":"journal-article","created":{"date-parts":[[2026,9,16]],"date-time":"2026-09-16T11:42:37Z","timestamp":1789558957000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Targeted NAD\n                    <sup>+<\/sup>\n                    Metabolic Reprogramming Enables Functional Endometrial Regeneration and Fertility Restoration in Intrauterine Adhesions"],"prefix":"10.1002","author":[{"given":"Yijia","family":"Zhou","sequence":"first","affiliation":[{"name":"Department of Obstetrics and Gynecology The First Affiliated Hospital Sun Yat\u2010sen University  Guangzhou Guangdong People's Republic of China"},{"name":"Guangdong Provincial Clinical Research 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