{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T02:59:57Z","timestamp":1790823597880,"version":"4.1.0"},"reference-count":75,"publisher":"Wiley","license":[{"start":{"date-parts":[[2026,9,30]],"date-time":"2026-09-30T00:00:00Z","timestamp":1790726400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,9,30]],"date-time":"2026-09-30T00:00:00Z","timestamp":1790726400000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Small"],"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>\n                    Metallic nanoparticles (NPs) and ultra\u2010high dose rate (UHDR, FLASH) irradiation are being developed to widen the therapeutic index of radiotherapy, but their interaction remains poorly defined. We assessed PEGylated platinum nanoparticles (Pt\u2010NPs) in 4T1 tumor spheroids and syngeneic 4T1 and MC38 mouse models exposed to conventional (CONV, 0.125\u00a0Gy\/s) or UHDR electron irradiation (\u223c200\u00a0Gy\/s mean dose rate). Pt\u2010NPs penetrated throughout 4T1 spheroids and were mainly cytoplasmic. In clonogenic assays, Pt\u2010NPs increased radiation\u2010induced loss of reproductive capacity under both dose\u2010rate conditions. LQ analysis suggested dose\u2010dependent divergence between modalities, with significantly greater radioenhancement under UHDR only at 12\u00a0Gy (SER: 65.9%\u00a0vs 40.8%, \u0394SER\u00a0=\u00a025.1 percentage points, 95% CI, 2.1\u201348.1,\n                    <jats:italic>p<\/jats:italic>\n                    \u00a0=\u00a00.034). Pt\u2010NPs did not measurably alter apoptosis or \u03b3\u2010H2AX kinetics. Micro\u2010CT confirmed intratumoral platinum at irradiation, but in vivo responses were heterogeneous. Pt\u2010NPs did not improve tumor control in the poorly immunogenic 4T1 model. In the more radiosensitive MC38 model, Pt\u2010NPs showed a nonsignificant trend toward improved tumor control and survival under CONV, with no comparable UHDR benefit. These findings identify an in vitro\u2010to\u2010in vivo disconnect and show that NP radioenhancement cannot be assumed to translate across dose\u2010rate regimens, tumor models, or host backgrounds.\n                  <\/jats:p>","DOI":"10.1002\/smll.75792","type":"journal-article","created":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T02:52:42Z","timestamp":1790823162000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Context\u2010Dependent Radioenhancement by Platinum Nanoparticles Under Conventional and Ultra\u2010High Dose\u2010Rate \u201cFLASH\u201d Radiotherapy"],"prefix":"10.1002","author":[{"given":"Cathyanne","family":"Schott","sequence":"first","affiliation":[{"name":"Molecular Radiotherapy and Therapeutic Innovation Gustave Roussy Inserm Universit\u00e9 Paris\u2010Saclay  Villejuif 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