{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,13]],"date-time":"2026-10-13T02:45:51Z","timestamp":1791859551491,"version":"4.3.4"},"reference-count":43,"publisher":"Wiley","license":[{"start":{"date-parts":[[2026,9,23]],"date-time":"2026-09-23T00:00:00Z","timestamp":1790121600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,9,23]],"date-time":"2026-09-23T00:00:00Z","timestamp":1790121600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/501100006322","name":"Institute for Molecular Science","doi-asserted-by":"publisher","award":["JPMXP1225MS5010"],"award-info":[{"award-number":["JPMXP1225MS5010"]}],"id":[{"id":"10.13039\/501100006322","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Small"],"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>\n                    Quantitative pH imaging is important for understanding pathological tissue environments and diagnosing diseases such as tumors and inflammation. MRI\u2010based pH quantification has been developed based on several approaches including chemical exchange saturation transfer and ratiometric probes. However,\u00a0existing approaches involve trade\u2010offs in sensitivity, probe complexity, and reversibility, and robust quantitative pH imaging remains challenging. Previously, we reported ratiometric MRI probes based on a simple core\u2013shell architecture in which a gadolinium\u2010loaded core and a pH\u2010responsive hydrogel shell independently contribute to longitudinal relaxivity (\n                    <jats:italic>r<\/jats:italic>\n                    <jats:sub>1<\/jats:sub>\n                    ) and transverse relaxivity (\n                    <jats:italic>r<\/jats:italic>\n                    <jats:sub>2<\/jats:sub>\n                    ), respectively. These probes enabled pH quantification using\n                    <jats:italic>r<\/jats:italic>\n                    <jats:sub>2<\/jats:sub>\n                    \/\n                    <jats:italic>r<\/jats:italic>\n                    <jats:sub>1<\/jats:sub>\n                    ratiometry although their pH responses were not optimized for the physiological pH range and their usable probe concentrations were limited. Here, we optimized the crosslinked network of the shell using tetraethylene glycol dimethacrylate, achieving substantial pH\u2010dependent changes in\n                    <jats:italic>r<\/jats:italic>\n                    <jats:sub>2<\/jats:sub>\n                    around physiological pH while preserving\n                    <jats:italic>r<\/jats:italic>\n                    <jats:sub>1<\/jats:sub>\n                    and extending the usable probe concentration range. Electron microscopy confirmed the core\u2013shell structure and elemental distribution of the probe. The resulting probe enabled quantitative pH imaging over pH 6.0\u20137.5 across probe concentrations from 0.5 to 1.5 wt.%. These findings establish a practical strategy for MRI\u2010based pH quantification, offering a step toward standardized non\u2010invasive pH measurements.\n                  <\/jats:p>","DOI":"10.1002\/smll.75796","type":"journal-article","created":{"date-parts":[[2026,9,23]],"date-time":"2026-09-23T13:00:42Z","timestamp":1790168442000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["A Ratiometric MRI Probe With a Tuned Crosslinked Network for Quantitative Imaging of Physiological pH"],"prefix":"10.1002","author":[{"ORCID":"https:\/\/orcid.org\/0009-0009-5908-437X","authenticated-orcid":false,"given":"Ken","family":"Kato","sequence":"first","affiliation":[{"name":"Core for Spin Life Sciences Okazaki Collaborative Platform National Institutes of Natural Sciences  Okazaki Aichi Japan"},{"name":"Exploratory Research Center on Life and Living Systems (ExCELLS) National Institutes of Natural Sciences  Okazaki Aichi 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Integrated Research Institute of Science Tokyo  Yokohama Kanagawa Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7187-9612","authenticated-orcid":false,"given":"Koichi","family":"Kato","sequence":"additional","affiliation":[{"name":"Core for Spin Life Sciences Okazaki Collaborative Platform National Institutes of Natural Sciences  Okazaki Aichi Japan"},{"name":"Exploratory Research Center on Life and Living Systems (ExCELLS) National Institutes of Natural Sciences  Okazaki Aichi Japan"},{"name":"Institute for Molecular Science (IMS) National Institutes of Natural Sciences  Okazaki Aichi Japan"},{"name":"Graduate School of Pharmaceutical Sciences Nagoya City University  Nagoya Aichi Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7103-1275","authenticated-orcid":false,"given":"Kazuya","family":"Kikuchi","sequence":"additional","affiliation":[{"name":"Core for Spin Life Sciences 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