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Herein, we report a curcumin (Cur)\u2010adapted nano\u2010composites (BiO\n                    <jats:sub>2\u2010X<\/jats:sub>\n                    \/Cur), integrated into a dissolvable microneedles (MNs) patch, for synergistic piezo\u2010sono\u2010thermal therapy against drug\u2010resistant skin infections. The natural compound Cur is engineered not merely as an anti\u2010inflammatory agent but as a critical molecular adapter that precisely tunes the interfacial charge dynamics and energy landscape at the composites interface, which extends carrier lifetime to 0.63 ns and significantly enhances oxygen adsorption capacity (\n                    <jats:italic>E<\/jats:italic>\n                    <jats:sub>ads<\/jats:sub>\n                    = \u20101.821 eV). Under ultrasound irradiation, the patch demonstrates superior piezo\u2010sonocatalytic activity (\u22480.6 V piezoelectric output and\n                    <jats:italic>d<\/jats:italic>\n                    <jats:sub>33<\/jats:sub>\n                    value of \u22122.9 \u00d7 10\n                    <jats:sup>\u221212<\/jats:sup>\n                    C\/N) to release reactive oxygen species and simultaneously delivers a substantial sono\u2010thermal effect (\u0394T &gt; 20 \u00b0C). The dissolvable MNs platform ensures precise and painless intradermal delivery of BiO\n                    <jats:sub>2\u2010X<\/jats:sub>\n                    \/Cur, enabling in vitro and in vivo near\u2010complete eradication (&gt;99.97%) of\n                    <jats:italic>Propionibacterium acnes<\/jats:italic>\n                    and methicillin\u2010resistant\n                    <jats:italic>Staphylococcus aureus<\/jats:italic>\n                    , downregulating pro\u2010inflammatory cytokines (IL\u20106, TNF\u2010\u03b1, HIF\u20101\u03b1) while upregulating reparative markers (IL\u201010, Nrf2). This work establishes an emerging paradigm of using natural molecules as precision adapters for engineering high\u2010performance composites, offering an intelligent and versatile platform for treating complex infectious diseases.\n                  <\/jats:p>","DOI":"10.1002\/smll.75811","type":"journal-article","created":{"date-parts":[[2026,9,16]],"date-time":"2026-09-16T12:03:49Z","timestamp":1789560229000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Curcumin\u2010Adapted Nano\u2010Composites within Dissolvable Microneedles for Precision\u2010Tuned Piezo\u2010Sono\u2010Thermal Antibiotic\u2010Free Acne Therapy"],"prefix":"10.1002","author":[{"given":"Yan","family":"Li","sequence":"first","affiliation":[{"name":"Biomedical Materials Engineering Research Center, Hubei Key Laboratory of Polymer Materials, Ministry\u2010of\u2010Education Key Laboratory for the Green Preparation and Application of Functional 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