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Herein, we engineered a Ti\n                    <jats:sub>3<\/jats:sub>\n                    C\n                    <jats:sub>2<\/jats:sub>\n                    MXene\/Cobalt\u2010based Metal\u2010Organic Framework (Co\u2010MOF) heterostructured nanozyme (CMX) via interfacial Ti\u2013O\u2013Co coordination between conductive Ti\n                    <jats:sub>3<\/jats:sub>\n                    C\n                    <jats:sub>2<\/jats:sub>\n                    MXene and redox\u2010active Co\u2010MOF. Different from physically mixed MXene\/MOF systems or externally stimulated antibacterial nanozymes, CMX was designed to strengthen interfacial catalytic synergy, modulate the local catalytic environment of Co sites, and boost Fenton\u2010like reactive oxygen species (ROS) generation under mild conditions. Consequently, the interface\u2010engineered CMX system exhibits strong bactericidal activity, markedly reducing the viability of\n                    <jats:italic>Escherichia coli<\/jats:italic>\n                    (\n                    <jats:italic>E. coli<\/jats:italic>\n                    ),\n                    <jats:italic>Staphylococcus aureus<\/jats:italic>\n                    (\n                    <jats:italic>S. aureus<\/jats:italic>\n                    ), and\n                    <jats:italic>methicillin\u2010resistant S. aureus<\/jats:italic>\n                    (\n                    <jats:italic>MRSA<\/jats:italic>\n                    ) by &gt;99% within 2\u00a0h at 200\u00a0\u00b5g\u00a0mL\n                    <jats:sup>\u22121<\/jats:sup>\n                    . In vivo evaluations in rat infected wound models demonstrate that topical CMX + H\n                    <jats:sub>2<\/jats:sub>\n                    O\n                    <jats:sub>2<\/jats:sub>\n                    treatment reduced bacterial burden and showed no obvious systemic toxicity within the tested observation period. Furthermore, the CMX\u2010based treatment alleviated local inflammation, promoted collagen deposition and angiogenesis\u2010associated marker expression, and accelerated wound closure, reaching \u223c95.2% closure by Day 10. This Ti\u2013O\u2013Co interface\u2010engineered nanozyme provides a promising topical non\u2010antibiotic strategy for antibacterial therapy and infected wound repair.\n                  <\/jats:p>","DOI":"10.1002\/smll.75822","type":"journal-article","created":{"date-parts":[[2026,9,21]],"date-time":"2026-09-21T15:17:16Z","timestamp":1790003836000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Interface\u2010Engineered Ti\n                    <sub>3<\/sub>\n                    C\n                    <sub>2<\/sub>\n                    MXene\/Co\u2010MOF Nanozymes With Electron Fast\u2010Track for Synergistic Pathogen Eradication and Wound Repair"],"prefix":"10.1002","author":[{"ORCID":"https:\/\/orcid.org\/0009-0006-5689-9977","authenticated-orcid":false,"given":"Han","family":"Zhang","sequence":"first","affiliation":[{"name":"Department of Orthopedics The Affiliated Hospital of Qingdao University  Qingdao 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