{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,30]],"date-time":"2026-09-30T06:56:09Z","timestamp":1790751369159,"version":"4.1.0"},"reference-count":64,"publisher":"Wiley","license":[{"start":{"date-parts":[[2026,9,29]],"date-time":"2026-09-29T00:00:00Z","timestamp":1790640000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2026,9,29]],"date-time":"2026-09-29T00:00:00Z","timestamp":1790640000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Small"],"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>The pathological aggregation of misfolded proteins into \u03b2\u2010sheet\u2010rich amyloid fibrils underlies a broad spectrum of debilitating diseases, yet strategies capable of effectively reversing these supramolecular assemblies remain an open challenge. Here, we demonstrate that a selective electrode\u2010fibril interaction could be achieved by quantifying the ratio of solvent\u2010exposed hydrophobic to polar residues. The interaction between insulin fibrils and graphite electrodes, compared to platinum, facilitates localization and selective degradation of \u03b2\u2010sheet\u2010rich amyloid fibrils under DC and pulsed\u2010DC stimulation. Importantly, the higher ratio of solvent\u2010exposed oxidation\u2010prone amino acids assists the reactive oxygen species (ROS)\u2010mediated catalytic oxidation and the selective degradation of insulin fibrils over lysozyme fibrils. Electrochemical stimulation not only disassembles fibrils but also reduces toxicity and restores insulin's biological activity. Overall, our findings highlight the critical roles of electrode\u2010fibril interaction, surface\u2010exposed oxidation\u2010prone amino acids, and proximity\u2010driven catalytic oxidation in dismantling fibrils, providing a foundation for amyloid\u2010targeting electrotherapeutics.<\/jats:p>","DOI":"10.1002\/smll.75888","type":"journal-article","created":{"date-parts":[[2026,9,30]],"date-time":"2026-09-30T06:04:04Z","timestamp":1790748244000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Structure\u2010Activity\u2010Based Electrode\u2010Fibril Interaction and Selective Electrochemical Disassembly of Fibrils via ROS\u2010Mediated Structural Collapse"],"prefix":"10.1002","author":[{"given":"Sarani","family":"Biswas","sequence":"first","affiliation":[{"name":"Department of Chemical Sciences Indian Institute of Science Education and Research Kolkata  Mohanpur 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