{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,24]],"date-time":"2026-09-24T15:05:09Z","timestamp":1790262309611,"version":"4.1.0"},"reference-count":37,"publisher":"Wiley","license":[{"start":{"date-parts":[[2026,9,24]],"date-time":"2026-09-24T00:00:00Z","timestamp":1790208000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2026,9,24]],"date-time":"2026-09-24T00:00:00Z","timestamp":1790208000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/501100012166","name":"National Key Research and Development Program of China","doi-asserted-by":"publisher","award":["2025YFE0100100"],"award-info":[{"award-number":["2025YFE0100100"]}],"id":[{"id":"10.13039\/501100012166","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100012166","name":"National Key Research and Development Program of China","doi-asserted-by":"publisher","award":["2023YFA1406503"],"award-info":[{"award-number":["2023YFA1406503"]}],"id":[{"id":"10.13039\/501100012166","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["52573163"],"award-info":[{"award-number":["52573163"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["52373006"],"award-info":[{"award-number":["52373006"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["52521002"],"award-info":[{"award-number":["52521002"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Small"],"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>\n                    The advent of copolymerization techniques involving \u03b1\u2010lipoic acid (LA) and vinyl monomers has significantly transformed the synthetic paradigms of self\u2010immolative poly(disulfide)s. Further leveraging their structure\u2013function\u2013property\u2013design interplay and eventually creating advanced materials are highly appreciated yet remains largely unexplored. A key advancement of this study lies in bridging the divide between controlled LA\/vinyl copolymerization and practical materials, by fabricating biodegradable anti\u2010melanoma nanomedicine derived from well\u2010defined self\u2010immolative poly(disulfide)s. To do so, reversible addition\u2013fragmentation chain transfer (RAFT) copolymerization of LA and 2,6\u2010diaminopyridine\u2010substituted vinyl monomer (DAP) is first conducted, endowing glutathione (GSH)\u2010degradable amphiphilic poly(disulfide)s vehicles, P(DAP\u2010\n                    <jats:italic>co<\/jats:italic>\n                    \u2010LANa), equipping hetero\u2010complementary H\u2010bonding DAP motifs toward the chemotherapeutic fluorouracil\u20101\u2010acetic acid (FUA). On the other hand, FUA is tethered onto the photothermal agent IR780 to afford multifunctional prodrug FUA780, incorporating an H\u2010bonding array, chemotherapeutic, and photothermal activities. DAP\/FUA H\u2010bonding interaction\u2010mediated assembly thus endow the construction of targeted smart nanomedicine FUA780@P(DAP\u2010\n                    <jats:italic>co<\/jats:italic>\n                    \u2010LANa). Moreover, to effectively cross the skin barrier, FUA780@P(DAP\u2010\n                    <jats:italic>co<\/jats:italic>\n                    \u2010LANa) is embedded within dissolvable microneedles, indeed standing out in malignant melanoma treatment, via spatiotemporal cargo delivery and synergistic chemo\/photothermal therapy (CT\/PTT). Such a controlled synthetic approach and well\u2010defined structural characteristics through LA\/vinyl copolymerization are anticipated to serve as a pivotal foundation for advancing the design principles underlying dynamic material paradigms.\n                  <\/jats:p>","DOI":"10.1002\/smll.75910","type":"journal-article","created":{"date-parts":[[2026,9,24]],"date-time":"2026-09-24T14:27:00Z","timestamp":1790260020000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Materializing RAFT\u2010Made Self\u2010Immolative Poly(Disulfide)s From \u03b1\u2010Lipoic Acid: Fabrication of Microneedle\u2010Enabled Biodegradable Nanomedicine for Anti\u2010Melanoma Therapy"],"prefix":"10.1002","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-5965-0268","authenticated-orcid":false,"given":"Zhijie","family":"Qiu","sequence":"first","affiliation":[{"name":"Hubei Engineering Research Center for Biomaterials and Medical Protective Materials School of Chemistry and Chemical Engineering Huazhong University of Science and Technology  Wuhan China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zeke","family":"Li","sequence":"additional","affiliation":[{"name":"Hubei Engineering Research Center for Biomaterials and Medical Protective Materials School of Chemistry and Chemical Engineering Huazhong University of Science and Technology  Wuhan China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5599-6819","authenticated-orcid":false,"given":"Senbin","family":"Chen","sequence":"additional","affiliation":[{"name":"Hubei Engineering Research Center for Biomaterials and Medical Protective Materials School of Chemistry and Chemical Engineering Huazhong University of Science and Technology  Wuhan China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jintao","family":"Zhu","sequence":"additional","affiliation":[{"name":"Hubei Engineering Research Center for Biomaterials and Medical Protective Materials School of Chemistry and Chemical Engineering Huazhong University of Science and Technology  Wuhan China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,9,24]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.1002\/adma.202415157"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.freeradbiomed.2019.10.410"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.1039\/c2sc20098h"},{"key":"e_1_2_9_5_1","doi-asserted-by":"publisher","DOI":"10.1021\/ja311961k"},{"key":"e_1_2_9_6_1","doi-asserted-by":"publisher","DOI":"10.1021\/acsmaterialslett.3c01265"},{"key":"e_1_2_9_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.biomaterials.2025.123527"},{"key":"e_1_2_9_8_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41467\u2010025\u201056507\u20104"},{"key":"e_1_2_9_9_1","doi-asserted-by":"publisher","DOI":"10.1021\/jacs.4c00395"},{"key":"e_1_2_9_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.actbio.2023.01.029"},{"key":"e_1_2_9_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cclet.2024.110570"},{"key":"e_1_2_9_12_1","doi-asserted-by":"publisher","DOI":"10.1021\/jacs.3c08248"},{"key":"e_1_2_9_13_1","doi-asserted-by":"publisher","DOI":"10.1002\/anie.202516164"},{"key":"e_1_2_9_14_1","doi-asserted-by":"publisher","DOI":"10.1021\/jacs.6c02848"},{"key":"e_1_2_9_15_1","doi-asserted-by":"publisher","DOI":"10.1021\/jacs.5c14377"},{"key":"e_1_2_9_16_1","doi-asserted-by":"publisher","DOI":"10.1021\/acsmacrolett.4c00839"},{"key":"e_1_2_9_17_1","doi-asserted-by":"publisher","DOI":"10.1021\/jacs.4c12438"},{"key":"e_1_2_9_18_1","doi-asserted-by":"publisher","DOI":"10.1021\/jacs.9b08957"},{"key":"e_1_2_9_19_1","doi-asserted-by":"publisher","DOI":"10.1021\/jacs.1c10359"},{"key":"e_1_2_9_20_1","doi-asserted-by":"publisher","DOI":"10.1021\/acs.accounts.5c00689"},{"key":"e_1_2_9_21_1","doi-asserted-by":"publisher","DOI":"10.1021\/acs.macromol.5c01498"},{"key":"e_1_2_9_22_1","doi-asserted-by":"publisher","DOI":"10.1002\/1521\u20103773(20020315)41:6<898::AID\u2010ANIE898>3.0.CO;2\u2010E"},{"key":"e_1_2_9_23_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.8511582"},{"key":"e_1_2_9_24_1","doi-asserted-by":"publisher","DOI":"10.1021\/cr990125q"},{"key":"e_1_2_9_25_1","doi-asserted-by":"publisher","DOI":"10.1039\/D1PY01061A"},{"key":"e_1_2_9_26_1","doi-asserted-by":"publisher","DOI":"10.1039\/b804260h"},{"key":"e_1_2_9_27_1","doi-asserted-by":"publisher","DOI":"10.1002\/adfm.202307543"},{"key":"e_1_2_9_28_1","doi-asserted-by":"publisher","DOI":"10.1002\/adfm.202523389"},{"key":"e_1_2_9_29_1","doi-asserted-by":"publisher","DOI":"10.1002\/adma.202502416"},{"key":"e_1_2_9_30_1","doi-asserted-by":"publisher","DOI":"10.1021\/acsnano.3c08359"},{"key":"e_1_2_9_31_1","doi-asserted-by":"publisher","DOI":"10.1002\/anie.202012315"},{"key":"e_1_2_9_32_1","doi-asserted-by":"publisher","DOI":"10.1039\/C5SM02843D"},{"key":"e_1_2_9_33_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.actbio.2022.12.067"},{"key":"e_1_2_9_34_1","doi-asserted-by":"publisher","DOI":"10.1002\/anie.202110028"},{"key":"e_1_2_9_35_1","doi-asserted-by":"publisher","DOI":"10.1021\/acsami.5c07590"},{"key":"e_1_2_9_36_1","doi-asserted-by":"crossref","DOI":"10.1021\/acsnano.5c01744","article-title":"Nanoigniter\u2010Integrated Microneedle Patches for Boosted Photothermal\u2010Mediated Multimodal Therapy: In Situ Tumor Microenvironment Igniting Strategy","volume":"19","author":"Peng S.","year":"2025","journal-title":"ACS Nano"},{"key":"e_1_2_9_37_1","doi-asserted-by":"publisher","DOI":"10.1002\/adma.202311246"},{"key":"e_1_2_9_38_1","doi-asserted-by":"publisher","DOI":"10.1021\/acsnano.2c08979"}],"container-title":["Small"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/smll.75910","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1002\/smll.75910","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/smll.75910","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,9,24]],"date-time":"2026-09-24T14:27:02Z","timestamp":1790260022000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/smll.75910"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,9,24]]},"references-count":37,"alternative-id":["10.1002\/smll.75910"],"URL":"https:\/\/doi.org\/10.1002\/smll.75910","archive":["Portico"],"relation":{},"ISSN":["1613-6810","1613-6829"],"issn-type":[{"value":"1613-6810","type":"print"},{"value":"1613-6829","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,9,24]]},"assertion":[{"value":"2026-07-24","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-09-16","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-09-24","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e75910"}}