{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,27]],"date-time":"2026-09-27T17:56:21Z","timestamp":1790531781325,"version":"4.1.0"},"reference-count":50,"publisher":"Wiley","license":[{"start":{"date-parts":[[2026,9,27]],"date-time":"2026-09-27T00:00:00Z","timestamp":1790467200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2026,9,27]],"date-time":"2026-09-27T00:00:00Z","timestamp":1790467200000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/501100012336","name":"Major State Basic Research Development Program of China","doi-asserted-by":"publisher","award":["2023YFB3810000"],"award-info":[{"award-number":["2023YFB3810000"]}],"id":[{"id":"10.13039\/501100012336","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100012336","name":"Major State Basic Research Development Program of China","doi-asserted-by":"publisher","award":["2023YFB3810002"],"award-info":[{"award-number":["2023YFB3810002"]}],"id":[{"id":"10.13039\/501100012336","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100012336","name":"Major State Basic Research Development Program of China","doi-asserted-by":"publisher","award":["2023YFB3810003"],"award-info":[{"award-number":["2023YFB3810003"]}],"id":[{"id":"10.13039\/501100012336","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["32271447"],"award-info":[{"award-number":["32271447"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["824B2054"],"award-info":[{"award-number":["824B2054"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["32301153"],"award-info":[{"award-number":["32301153"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["U22A20333"],"award-info":[{"award-number":["U22A20333"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["U24A20525"],"award-info":[{"award-number":["U24A20525"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003392","name":"Natural Science Foundation of Fujian Province","doi-asserted-by":"publisher","award":["2024J09005"],"award-info":[{"award-number":["2024J09005"]}],"id":[{"id":"10.13039\/501100003392","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Small"],"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>\n                    Uveitis poses a severe threat to vision and represents a critical clinical challenge. Conventional therapeutic approaches often exhibit limited efficacy in controlling disease progression and lack efficient mechanisms for managing localized oxidative stress. Given that molecular hydrogen (H\n                    <jats:sub>2<\/jats:sub>\n                    ) holds substantial promise for treating oxidative and inflammatory diseases via its selective antioxidant properties, we report a metal\u2013organic framework (MOF) nanozyme\u2010based hydrogen nanogenerator. This system integrates photocatalytic visible\u2010light\u2010triggered H\n                    <jats:sub>2<\/jats:sub>\n                    generation with multi\u2010enzyme\u2010like antioxidant functions for targeted uveitis management. The engineered Pt\u2010embedded MOF nanozymes (Pt@MOF) concurrently catalyze hydrogen evolution under visible light and display superoxide dismutase\u2010 and catalase\u2010like activities, achieving comprehensive scavenging of overproduced reactive oxygen species (ROS). Furthermore, camouflaging the nanozyme with M2 macrophage\u2010derived cell membrane vesicles (CMVs) endows the nanoplatform with active inflammation\u2010targeting ability, thereby enhancing the accumulation in inflamed ocular tissues. Following topical administration, this biomimetic nanomedicine successfully mitigates oxidative stress and suppresses pro\u2010inflammatory cytokines both in vitro and in a rat model of acute uveitis. Overall, this study underscores the immense potential of integrating light\u2010driven hydrogen therapy with nanozyme therapy, offering a highly effective strategy that could revolutionize future therapeutic interventions for inflammatory eye diseases.\n                  <\/jats:p>","DOI":"10.1002\/smll.75929","type":"journal-article","created":{"date-parts":[[2026,9,27]],"date-time":"2026-09-27T16:59:15Z","timestamp":1790528355000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["M2 Macrophage\u2010Mimetic Metal\u2010Organic Framework Nanozyme With Visible\u2010Light\u2010Driven Hydrogen Evolution for Uveitis Therapy"],"prefix":"10.1002","author":[{"given":"Shundong","family":"Cai","sequence":"first","affiliation":[{"name":"Xiamen University Affiliated Xiamen Eye Center Eye Institute of Xiamen University School of Medicine Xiamen University  Xiamen China"},{"name":"Fujian Provincial Key Laboratory of Ophthalmology and Visual Science Fujian Engineering and Research Center of Eye Regenerative Medicine  Xiamen China"},{"name":"School of Pharmacy Xiamen Medical College  Xiamen China"},{"name":"State Key Laboratory of Physical Chemistry of Solid Surfaces &amp; The MOE Key Laboratory of Spectrochemical Analysis &amp; Instrumentation College of Chemistry and Chemical Engineering Xiamen University  Xiamen China"},{"name":"State Key Laboratory of Cellular Stress Biology School of Life Science Xiamen University  Xiamen China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0000-0528-4741","authenticated-orcid":false,"given":"Mengdie","family":"Li","sequence":"additional","affiliation":[{"name":"Xiamen University Affiliated Xiamen Eye Center Eye Institute of Xiamen University School of Medicine Xiamen University  Xiamen China"},{"name":"Fujian Provincial Key Laboratory of Ophthalmology and Visual Science Fujian Engineering and Research Center of Eye Regenerative Medicine  Xiamen China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0007-6436-0485","authenticated-orcid":false,"given":"Jingbin","family":"Zhuang","sequence":"additional","affiliation":[{"name":"Xiamen University Affiliated Xiamen Eye Center Eye Institute of Xiamen University School of Medicine Xiamen University  Xiamen China"},{"name":"Fujian Provincial Key Laboratory of Ophthalmology and Visual Science Fujian Engineering and Research Center of Eye Regenerative Medicine  Xiamen China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jinfa","family":"Ye","sequence":"additional","affiliation":[{"name":"Xiamen University Affiliated Xiamen Eye Center Eye Institute of Xiamen University School of Medicine Xiamen University  Xiamen China"},{"name":"Fujian Provincial Key Laboratory of Ophthalmology and Visual Science Fujian Engineering and Research Center of Eye Regenerative Medicine  Xiamen China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Songyi","family":"Wang","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Physical Chemistry of Solid Surfaces &amp; The MOE Key Laboratory of Spectrochemical Analysis &amp; Instrumentation College of Chemistry and Chemical Engineering Xiamen University  Xiamen China"},{"name":"State Key Laboratory of Cellular Stress Biology School of Life Science Xiamen University  Xiamen China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jinglei","family":"Zhang","sequence":"additional","affiliation":[{"name":"Xiamen University Affiliated Xiamen Eye Center Eye Institute of Xiamen University School of Medicine Xiamen University  Xiamen China"},{"name":"Fujian Provincial Key Laboratory of Ophthalmology and Visual Science Fujian Engineering and Research Center of Eye Regenerative Medicine  Xiamen China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mingyou","family":"Zhang","sequence":"additional","affiliation":[{"name":"Xiamen University Affiliated Xiamen Eye Center Eye Institute of Xiamen University School of Medicine Xiamen University  Xiamen China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qixuan","family":"Dai","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Physical Chemistry of Solid Surfaces &amp; The MOE Key Laboratory of Spectrochemical Analysis &amp; Instrumentation College of Chemistry and Chemical Engineering Xiamen University  Xiamen China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yun","family":"Han","sequence":"additional","affiliation":[{"name":"Xiamen University Affiliated Xiamen Eye Center Eye Institute of Xiamen University School of Medicine Xiamen University  Xiamen China"},{"name":"Fujian Provincial Key Laboratory of Ophthalmology and Visual Science Fujian Engineering and Research Center of Eye Regenerative Medicine  Xiamen China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Min","family":"Su","sequence":"additional","affiliation":[{"name":"School of Pharmacy Xiamen Medical College  Xiamen China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7458-2590","authenticated-orcid":false,"given":"Wei","family":"Li","sequence":"additional","affiliation":[{"name":"Xiamen University Affiliated Xiamen Eye Center Eye Institute of Xiamen University School of Medicine Xiamen University  Xiamen China"},{"name":"Fujian Provincial Key Laboratory of Ophthalmology and Visual Science Fujian Engineering and Research Center of Eye Regenerative Medicine  Xiamen China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2613-7286","authenticated-orcid":false,"given":"Gang","family":"Liu","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Physical Chemistry of Solid Surfaces &amp; The MOE Key Laboratory of Spectrochemical Analysis &amp; Instrumentation College of Chemistry and Chemical Engineering Xiamen University  Xiamen China"},{"name":"State Key Laboratory of Cellular Stress Biology School of Life Science Xiamen University  Xiamen China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1694-9363","authenticated-orcid":false,"given":"Chengchao","family":"Chu","sequence":"additional","affiliation":[{"name":"Xiamen University Affiliated Xiamen Eye Center Eye Institute of Xiamen University School of Medicine Xiamen University  Xiamen China"},{"name":"Fujian Provincial Key Laboratory of Ophthalmology and Visual Science Fujian Engineering and Research Center of Eye Regenerative Medicine  Xiamen China"},{"name":"State Key Laboratory of Cellular Stress Biology School of Life Science Xiamen University  Xiamen China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,9,27]]},"reference":[{"key":"e_1_2_10_2_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1509852"},{"key":"e_1_2_10_3_1","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.m4979"},{"key":"e_1_2_10_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ophtha.2025.05.026"},{"key":"e_1_2_10_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.preteyeres.2025.101380"},{"key":"e_1_2_10_6_1","doi-asserted-by":"publisher","DOI":"10.1021\/acsnano.3c08869"},{"key":"e_1_2_10_7_1","doi-asserted-by":"publisher","DOI":"10.1021\/acsami.4c00564"},{"key":"e_1_2_10_8_1","doi-asserted-by":"publisher","DOI":"10.1038\/s44286\u2010025\u201000259\u2010x"},{"key":"e_1_2_10_9_1","doi-asserted-by":"publisher","DOI":"10.1002\/adma.202311429"},{"key":"e_1_2_10_10_1","doi-asserted-by":"publisher","DOI":"10.1021\/jacs.5c02114"},{"key":"e_1_2_10_11_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41467\u2010022\u201033475\u20107"},{"key":"e_1_2_10_12_1","doi-asserted-by":"publisher","DOI":"10.1021\/acsnano.5c10754"},{"key":"e_1_2_10_13_1","doi-asserted-by":"publisher","DOI":"10.1039\/c8cs00457a"},{"key":"e_1_2_10_14_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12951\u2010026\u201004604\u2010x"},{"key":"e_1_2_10_15_1","doi-asserted-by":"publisher","DOI":"10.1002\/adhm.202402066"},{"key":"e_1_2_10_16_1","doi-asserted-by":"publisher","DOI":"10.1002\/anie.201209903"},{"key":"e_1_2_10_17_1","doi-asserted-by":"publisher","DOI":"10.1002\/bmm2.70029"},{"key":"e_1_2_10_18_1","doi-asserted-by":"publisher","DOI":"10.7150\/thno.83543"},{"key":"e_1_2_10_19_1","doi-asserted-by":"publisher","DOI":"10.1002\/adma.202205324"},{"key":"e_1_2_10_20_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41565\u2010023\u201001346\u2010x"},{"key":"e_1_2_10_21_1","doi-asserted-by":"publisher","DOI":"10.1002\/adma.202206861"},{"key":"e_1_2_10_22_1","doi-asserted-by":"publisher","DOI":"10.1002\/adma.202411030"},{"key":"e_1_2_10_23_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jcis.2026.140968"},{"key":"e_1_2_10_24_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41571\u2010022\u201000699\u2010x"},{"key":"e_1_2_10_25_1","doi-asserted-by":"publisher","DOI":"10.1002\/adfm.202402724"},{"key":"e_1_2_10_26_1","doi-asserted-by":"publisher","DOI":"10.1002\/adma.202304123"},{"key":"e_1_2_10_27_1","doi-asserted-by":"publisher","DOI":"10.1126\/sciadv.ado6798"},{"key":"e_1_2_10_28_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bios.2025.117393"},{"key":"e_1_2_10_29_1","doi-asserted-by":"publisher","DOI":"10.1021\/acsami.5c01695"},{"key":"e_1_2_10_30_1","doi-asserted-by":"publisher","DOI":"10.1021\/acsami.0c04349"},{"key":"e_1_2_10_31_1","doi-asserted-by":"publisher","DOI":"10.1021\/acsnano.4c08157"},{"key":"e_1_2_10_32_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.biomaterials.2024.122764"},{"key":"e_1_2_10_33_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.mtbio.2022.100214"},{"key":"e_1_2_10_34_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.biomaterials.2025.123353"},{"key":"e_1_2_10_35_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jconrel.2022.02.033"},{"key":"e_1_2_10_36_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.biomaterials.2022.121437"},{"key":"e_1_2_10_37_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41467\u2010023\u201040280\u20103"},{"key":"e_1_2_10_38_1","doi-asserted-by":"publisher","DOI":"10.1002\/adma.202108817"},{"key":"e_1_2_10_39_1","doi-asserted-by":"publisher","DOI":"10.1126\/sciadv.abf7820"},{"key":"e_1_2_10_40_1","doi-asserted-by":"publisher","DOI":"10.1021\/acsnano.1c08689"},{"key":"e_1_2_10_41_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41467\u2010020\u201016439\u20107"},{"key":"e_1_2_10_42_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1308887110"},{"key":"e_1_2_10_43_1","doi-asserted-by":"publisher","DOI":"10.1186\/s13287\u2010024\u201004025\u20103"},{"key":"e_1_2_10_44_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bioactmat.2024.02.015"},{"key":"e_1_2_10_45_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41565\u2010024\u201001618\u20100"},{"key":"e_1_2_10_46_1","doi-asserted-by":"publisher","DOI":"10.1126\/sciadv.aaz0748"},{"key":"e_1_2_10_47_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.preteyeres.2012.10.004"},{"key":"e_1_2_10_48_1","doi-asserted-by":"publisher","DOI":"10.1021\/acsnano.3c12580"},{"key":"e_1_2_10_49_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41420\u2010023\u201001564\u20101"},{"key":"e_1_2_10_50_1","doi-asserted-by":"publisher","DOI":"10.1038\/nature19763"},{"key":"e_1_2_10_51_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1421815112"}],"container-title":["Small"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/smll.75929","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1002\/smll.75929","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/smll.75929","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,9,27]],"date-time":"2026-09-27T16:59:17Z","timestamp":1790528357000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/smll.75929"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,9,27]]},"references-count":50,"alternative-id":["10.1002\/smll.75929"],"URL":"https:\/\/doi.org\/10.1002\/smll.75929","archive":["Portico"],"relation":{},"ISSN":["1613-6810","1613-6829"],"issn-type":[{"value":"1613-6810","type":"print"},{"value":"1613-6829","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,9,27]]},"assertion":[{"value":"2026-06-06","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-09-17","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-09-27","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e75929"}}