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Here, we present an x\u2010ray\u2010sensitive engineered bacterium, composed of\n                    <jats:italic>Escherichia coli<\/jats:italic>\n                    (\n                    <jats:italic>E. coli<\/jats:italic>\n                    ) and gold\u2010silver nanorods (Ec\u2010GS NRs), for synergistic radioimmunotherapy and photoacoustic (PA) immunomonitoring of triple\u2010negative breast cancer (TNBC). Upon x\u2010ray irradiation, Ag\n                    <jats:sup>+<\/jats:sup>\n                    release induces bacterial damage, stimulating the host immune system and triggering immunogenic tumor cell death. Moreover, radiation\u2010induced etching alters nanorod optoacoustic properties, enabling noninvasive PA monitoring of immunotherapy initiation. In TNBC models, Ec\u2010GS NRs combined with x\u2010ray irradiation achieved near\u2010complete tumor regression through enhanced radioimmunotherapy. Concurrently, PA signal ratio (PA\n                    <jats:sub>808<\/jats:sub>\n                    \/PA\n                    <jats:sub>1064<\/jats:sub>\n                    ) increased 127\u2010fold, allowing in situ monitoring of immune activation. Notably, Ec\u2010GS NRs elicited a strong abscopal effect, suppressing distant metastases and extending overall survival. This study thus establishes a bacteria\u2010enabled radioimmunotheranostic strategy integrating x\u2010ray\u2010controllable immune activation, radiosensitization, and PA\u2010immunomonitoring to address limitations in precision cancer therapy.\n                  <\/jats:p>","DOI":"10.1002\/smll.75931","type":"journal-article","created":{"date-parts":[[2026,10,7]],"date-time":"2026-10-07T11:09:32Z","timestamp":1791371372000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["X\u2010Ray\u2010Responsive Engineered Bacteria for Synergistic Radioimmunotherapy and Photoacoustic Immunomonitoring of Triple\u2010Negative Breast Cancer"],"prefix":"10.1002","author":[{"given":"Si","family":"Zheng","sequence":"first","affiliation":[{"name":"Department of Medicine Ultrasonics Nanfang Hospital Southern Medical University  Guangzhou China"},{"name":"Research Center for Advanced Detection Materials and Medical Imaging Devices 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