{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,4]],"date-time":"2026-10-04T14:51:44Z","timestamp":1791125504497,"version":"4.1.0"},"reference-count":78,"publisher":"Wiley","license":[{"start":{"date-parts":[[2026,10,4]],"date-time":"2026-10-04T00:00:00Z","timestamp":1791072000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2026,10,4]],"date-time":"2026-10-04T00:00:00Z","timestamp":1791072000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82303705"],"award-info":[{"award-number":["82303705"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82572320"],"award-info":[{"award-number":["82572320"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100014418","name":"Harbin Medical University Cancer Hospital","doi-asserted-by":"publisher","award":["PDYS2024\u201014"],"award-info":[{"award-number":["PDYS2024\u201014"]}],"id":[{"id":"10.13039\/100014418","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Small"],"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>The inevitable recurrence of glioblastoma multiforme post\u2010resection is primarily driven by infiltrative residual cells and a profoundly immunosuppressive tumor microenvironment (TME) that evades innate immune surveillance. In the present study, an injectable, photo\u2010crosslinkable carboxymethyl chitosan (CMCS)\u2010based hydrogel (si\u2010HAX1&amp;Quercetin@Gel) was engineered to achieve localized, synergistic chemo\u2010immunotherapy within the surgical cavity. The findings demonstrate that the localized release of si\u2010HAX1 triggers robust endoplasmic reticulum stress\u2010mediated immunogenic cell death, leading to significant CRT surface translocation. Concurrently, Quercetin acts as a small\u2010molecule antagonist of the CD47\u2010signal regulatory protein \u03b1 axis, dismantling the \u201cdon't eat me\u201d shield that protects glioma cells from macrophage\u2010mediated phagocytosis. In an in vivo postoperative glioblastoma model, the si\u2010HAX1&amp;Quercetin@Gel effectively suppressed tumor regrowth, increased the M1\/M2 macrophage ratio and recruited CD8+ T cells, thereby extending median survival time. Moreover, this localized intervention sensitized residual tumors to intratumorally administered anti\u2010programmed cell death protein 1 therapy by upregulating IFN\u2010\u03b3 and remodeling the TME. By integrating biomaterial engineering with deep molecular targeting of HAX1 and CD47, we provide a robust strategy to transform the post\u2010surgical cavity into an active immunological zone, offering a potent solution to combat malignant glioma recurrence.<\/jats:p>","DOI":"10.1002\/smll.76032","type":"journal-article","created":{"date-parts":[[2026,10,4]],"date-time":"2026-10-04T13:52:46Z","timestamp":1791121966000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Dual\u2010Targeting of ER Stress and the CD47\u2010SIRP\u03b1 Axis via an In Situ Hydrogel Prevents Postoperative Glioblastoma Recurrence"],"prefix":"10.1002","author":[{"given":"Xue","family":"Guan","sequence":"first","affiliation":[{"name":"Animal Laboratory Center The Second Affiliated Hospital of Harbin Medical University  Harbin People's Republic of China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9073-6016","authenticated-orcid":false,"given":"Wei","family":"Zhang","sequence":"additional","affiliation":[{"name":"Key Laboratory of Bio\u2010based Material Science &amp; Technology (Ministry of Education) Northeast Forestry University  Harbin Heilongjiang People's Republic of China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yujie","family":"Wang","sequence":"additional","affiliation":[{"name":"The Department of Neurosurgery Harbin Medical University Cancer Hospital  Harbin Heilongjiang People's Republic of China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0001-1814-7946","authenticated-orcid":false,"given":"Jianheng","family":"Gu","sequence":"additional","affiliation":[{"name":"The Department of Neurosurgery Harbin Medical University Cancer Hospital  Harbin Heilongjiang People's Republic of China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhonghua","family":"Lv","sequence":"additional","affiliation":[{"name":"The Department of Neurosurgery Harbin Medical University Cancer Hospital  Harbin Heilongjiang People's Republic of China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zengfu","family":"Li","sequence":"additional","affiliation":[{"name":"The Department of Neurosurgery Harbin Medical University Cancer Hospital  Harbin Heilongjiang People's Republic of China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaoyang","family":"Sun","sequence":"additional","affiliation":[{"name":"The Department of Neurosurgery Harbin Medical University Cancer Hospital  Harbin Heilongjiang People's Republic of China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shouli","family":"Guo","sequence":"additional","affiliation":[{"name":"Animal Laboratory Center The Second Affiliated Hospital of Harbin Medical University  Harbin People's Republic of China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9394-5016","authenticated-orcid":false,"given":"Peng","family":"Liang","sequence":"additional","affiliation":[{"name":"The Department of Neurosurgery Harbin Medical University Cancer Hospital  Harbin Heilongjiang People's Republic of China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1822-928X","authenticated-orcid":false,"given":"Chenlong","family":"Li","sequence":"additional","affiliation":[{"name":"The Department of Neurosurgery Harbin Medical University Cancer Hospital  Harbin Heilongjiang People's Republic of China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,10,4]]},"reference":[{"key":"e_1_2_10_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ymthe.2025.12.019"},{"key":"e_1_2_10_3_1","doi-asserted-by":"publisher","DOI":"10.1097\/JS9.0000000000002488"},{"key":"e_1_2_10_4_1","doi-asserted-by":"publisher","DOI":"10.3390\/cancers12010018"},{"key":"e_1_2_10_5_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41467\u2010025\u201067415\u2010y"},{"key":"e_1_2_10_6_1","doi-asserted-by":"publisher","DOI":"10.1093\/neuonc\/noaf080"},{"key":"e_1_2_10_7_1","doi-asserted-by":"publisher","DOI":"10.1002\/cac2.12579"},{"key":"e_1_2_10_8_1","doi-asserted-by":"publisher","DOI":"10.3389\/fncel.2017.00420"},{"key":"e_1_2_10_9_1","doi-asserted-by":"publisher","DOI":"10.1002\/stem.2741"},{"key":"e_1_2_10_10_1","doi-asserted-by":"publisher","DOI":"10.1101\/cshperspect.a004184"},{"key":"e_1_2_10_11_1","doi-asserted-by":"publisher","DOI":"10.1517\/14728222.2011.561787"},{"key":"e_1_2_10_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jmb.2006.10.057"},{"key":"e_1_2_10_13_1","doi-asserted-by":"publisher","DOI":"10.1111\/cas.13663"},{"key":"e_1_2_10_14_1","doi-asserted-by":"publisher","DOI":"10.1142\/S0192415X2450023X"},{"key":"e_1_2_10_15_1","doi-asserted-by":"publisher","DOI":"10.1002\/adhm.202505171"},{"key":"e_1_2_10_16_1","doi-asserted-by":"publisher","DOI":"10.3390\/ijms231910991"},{"key":"e_1_2_10_17_1","doi-asserted-by":"publisher","DOI":"10.1002\/adhm.202101578"},{"key":"e_1_2_10_18_1","doi-asserted-by":"publisher","DOI":"10.1002\/advs.202412507"},{"key":"e_1_2_10_19_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.biomaterials.2022.121450"},{"key":"e_1_2_10_20_1","doi-asserted-by":"publisher","DOI":"10.1021\/acsami.5c08084"},{"key":"e_1_2_10_21_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12645\u2010018\u20100044\u20106"},{"key":"e_1_2_10_22_1","doi-asserted-by":"publisher","DOI":"10.1172\/JCI120481"},{"key":"e_1_2_10_23_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1521069113"},{"key":"e_1_2_10_24_1","doi-asserted-by":"publisher","DOI":"10.1093\/neuonc\/noy148.1052"},{"key":"e_1_2_10_25_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10495\u2010016\u20101286\u20106"},{"key":"e_1_2_10_26_1","doi-asserted-by":"publisher","DOI":"10.1186\/s11658\u2010023\u201000466\u20105"},{"key":"e_1_2_10_27_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41467\u2010022\u201029137\u20103"},{"key":"e_1_2_10_28_1","doi-asserted-by":"publisher","DOI":"10.1002\/adma.202418053"},{"key":"e_1_2_10_29_1","doi-asserted-by":"publisher","DOI":"10.1172\/JCI176851"},{"key":"e_1_2_10_30_1","doi-asserted-by":"publisher","DOI":"10.1146\/annurev\u2010immunol\u2010032713\u2010120142"},{"key":"e_1_2_10_31_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.coi.2012.01.010"},{"key":"e_1_2_10_32_1","doi-asserted-by":"publisher","DOI":"10.1093\/neuonc\/noaa222.545"},{"key":"e_1_2_10_33_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1470\u20102045(24)00656\u20109"},{"key":"e_1_2_10_34_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41467\u2010023\u201037328\u20109"},{"key":"e_1_2_10_35_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ophtha.2018.12.045"},{"key":"e_1_2_10_36_1","doi-asserted-by":"publisher","DOI":"10.1126\/scitranslmed.aag2942"},{"key":"e_1_2_10_37_1","doi-asserted-by":"publisher","DOI":"10.1136\/jitc\u20102019\u2010000337"},{"key":"e_1_2_10_38_1","doi-asserted-by":"publisher","DOI":"10.4161\/21624011.2014.955691"},{"key":"e_1_2_10_39_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrd2742"},{"key":"e_1_2_10_40_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrd1775"},{"key":"e_1_2_10_41_1","doi-asserted-by":"publisher","DOI":"10.1021\/ja9037615"},{"key":"e_1_2_10_42_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijbiomac.2017.12.078"},{"key":"e_1_2_10_43_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.addr.2009.08.004"},{"key":"e_1_2_10_44_1","doi-asserted-by":"publisher","DOI":"10.1038\/natrevmats.2016.71"},{"key":"e_1_2_10_45_1","doi-asserted-by":"publisher","DOI":"10.3389\/fbioe.2021.723490"},{"key":"e_1_2_10_46_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41573\u2010024\u201000920\u20109"},{"key":"e_1_2_10_47_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41573\u2010018\u20100006\u2010z"},{"key":"e_1_2_10_48_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41565\u2010020\u201000843\u20107"},{"key":"e_1_2_10_49_1","doi-asserted-by":"publisher","DOI":"10.1089\/ten.TEA.2020.0124"},{"key":"e_1_2_10_50_1","doi-asserted-by":"publisher","DOI":"10.7150\/thno.35606"},{"key":"e_1_2_10_51_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.actbio.2018.09.020"},{"key":"e_1_2_10_52_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.actbio.2017.09.011"},{"key":"e_1_2_10_53_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41586\u2010018\u20100368\u20108"},{"key":"e_1_2_10_54_1","doi-asserted-by":"publisher","DOI":"10.1021\/acs.chemrev.5c00182"},{"key":"e_1_2_10_55_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.carbpol.2018.03.031"},{"key":"e_1_2_10_56_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.trecan.2020.02.022"},{"key":"e_1_2_10_57_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12943\u2010025\u201002477\u20106"},{"key":"e_1_2_10_58_1","doi-asserted-by":"publisher","DOI":"10.1002\/advs.201900069"},{"key":"e_1_2_10_59_1","doi-asserted-by":"publisher","DOI":"10.1155\/2017\/5285890"},{"key":"e_1_2_10_60_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.isci.2020.101341"},{"key":"e_1_2_10_61_1","doi-asserted-by":"publisher","DOI":"10.1186\/s13045\u2010022\u201001385\u20102"},{"key":"e_1_2_10_62_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jconrel.2025.02.042"},{"key":"e_1_2_10_63_1","doi-asserted-by":"publisher","DOI":"10.1111\/1541\u20104337.70146"},{"key":"e_1_2_10_64_1","doi-asserted-by":"publisher","DOI":"10.1002\/jcp.25588"},{"key":"e_1_2_10_65_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41592\u2010020\u20100906\u20109"},{"key":"e_1_2_10_66_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41467\u2010020\u201016272\u2010y"},{"key":"e_1_2_10_67_1","doi-asserted-by":"publisher","DOI":"10.3390\/gels8090573"},{"key":"e_1_2_10_68_1","doi-asserted-by":"publisher","DOI":"10.3390\/antiox10091476"},{"key":"e_1_2_10_69_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.biopha.2018.07.106"},{"key":"e_1_2_10_70_1","doi-asserted-by":"publisher","DOI":"10.1021\/ja300174v"},{"key":"e_1_2_10_71_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bioactmat.2025.07.024"},{"key":"e_1_2_10_72_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.carbpol.2025.123355"},{"key":"e_1_2_10_73_1","doi-asserted-by":"publisher","DOI":"10.1038\/nmeth.2956"},{"key":"e_1_2_10_74_1","doi-asserted-by":"publisher","DOI":"10.1002\/1878\u20100261.13190"},{"key":"e_1_2_10_75_1","doi-asserted-by":"publisher","DOI":"10.1093\/database\/bav082"},{"key":"e_1_2_10_76_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.omtn.2019.12.011"},{"key":"e_1_2_10_77_1","doi-asserted-by":"publisher","DOI":"10.1002\/jcc.21334"},{"key":"e_1_2_10_78_1","doi-asserted-by":"publisher","DOI":"10.1093\/nar\/gky439"},{"key":"e_1_2_10_79_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140\u20106736(25)00822\u20100"}],"container-title":["Small"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/smll.76032","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1002\/smll.76032","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/smll.76032","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,10,4]],"date-time":"2026-10-04T13:52:48Z","timestamp":1791121968000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/smll.76032"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,10,4]]},"references-count":78,"alternative-id":["10.1002\/smll.76032"],"URL":"https:\/\/doi.org\/10.1002\/smll.76032","archive":["Portico"],"relation":{},"ISSN":["1613-6810","1613-6829"],"issn-type":[{"value":"1613-6810","type":"print"},{"value":"1613-6829","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,10,4]]},"assertion":[{"value":"2026-06-18","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-09-22","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-10-04","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e76032"}}