{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,30]],"date-time":"2026-09-30T06:57:10Z","timestamp":1790751430510,"version":"4.1.0"},"reference-count":47,"publisher":"Wiley","license":[{"start":{"date-parts":[[2026,9,29]],"date-time":"2026-09-29T00:00:00Z","timestamp":1790640000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2026,9,29]],"date-time":"2026-09-29T00:00:00Z","timestamp":1790640000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/501100012226","name":"Fundamental Research Funds for the Central Universities","doi-asserted-by":"publisher","award":["E2EG6802X2"],"award-info":[{"award-number":["E2EG6802X2"]}],"id":[{"id":"10.13039\/501100012226","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Small"],"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>\n                    Inflammatory bowel disease (IBD) is characterized by chronic inflammation and excessive reactive oxygen species (ROS) production, leading to mucosal damage and impaired immune homeostasis. Here, we report the development of a core\u2013shell structured barium titanate @ cerium oxide nanozyme (BTO@CeO\n                    <jats:sub>x<\/jats:sub>\n                    , x = 1.9, 1.8, and 1.85), functioning as an orally administered \u201cbarium meal\u201d for targeted IBD imaging and treatment. Leveraging the inherent piezoelectric properties of BaTiO\n                    <jats:sub>3<\/jats:sub>\n                    , we imbue this nanozyme with a built\u2010in piezoelectric electron sponge effect, enhancing its catalytic efficiency. Upon ultrasound stimulation, the piezoelectric interface dynamically modulates charges that sustain redox reactions in CeO\n                    <jats:sub>x<\/jats:sub>\n                    , enhancing its superoxide dismutase (SOD)\u2010 and catalase (CAT)\u2010 like catalytic activities for scavenging ROS and producing oxygen. Following oral administration, BTO@CeO\n                    <jats:sub>x<\/jats:sub>\n                    demonstrates excellent gastrointestinal stability, selectively accumulating at IBD lesions, enabling real\u2010time computed tomography (CT) imaging and lesion tracking. Concurrently, it efficiently catalyzes ROS elimination, alleviates inflammation, restores immune balance, and reconstructs the intestinal mucosal barrier. The synergy of ultrasound\u2010triggered piezoelectric modulation and nanozyme catalysis offer a controllable, noninvasive, and lesion\u2010specific approach to the treatment of inflammatory diseases.\n                  <\/jats:p>","DOI":"10.1002\/smll.76043","type":"journal-article","created":{"date-parts":[[2026,9,30]],"date-time":"2026-09-30T06:09:23Z","timestamp":1790748563000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Engineering a Built\u2010in Piezoelectric Electron Sponge in Swallow Nanozyme for Inflammatory Bowel Disease Therapy"],"prefix":"10.1002","author":[{"given":"Zhuoheng","family":"Jiang","sequence":"first","affiliation":[{"name":"Beijing Institute of Nanoenergy and Nanosystems Chinese Academy of Sciences  Beijing People's Republic of China"},{"name":"School of Nanoscience and Engineering University of Chinese Academy of Sciences  Beijing People's Republic of China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhaoyang","family":"Yue","sequence":"additional","affiliation":[{"name":"Beijing Institute of Nanoenergy and Nanosystems Chinese Academy of Sciences  Beijing People's Republic of China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qinyu","family":"Zhao","sequence":"additional","affiliation":[{"name":"Beijing Institute of Nanoenergy and Nanosystems Chinese Academy of Sciences  Beijing People's Republic of China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Quanhong","family":"Hu","sequence":"additional","affiliation":[{"name":"Beijing Institute of Nanoenergy and Nanosystems Chinese Academy of Sciences  Beijing People's Republic of China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yunchao","family":"Zhao","sequence":"additional","affiliation":[{"name":"Beijing Institute of Nanoenergy and Nanosystems Chinese Academy of Sciences  Beijing People's Republic of 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China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1041-4533","authenticated-orcid":false,"given":"Linlin","family":"Li","sequence":"additional","affiliation":[{"name":"School of Biomedical Engineering Qilu Hospital Shandong University  Jinan People's Republic of China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,9,29]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrgastro.2017.136"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.1038\/ncpgasthep1004"},{"key":"e_1_2_9_4_1","doi-asserted-by":"crossref","first-page":"123","DOI":"10.1016\/S0140-6736(19)32545-0","article-title":"Colorectal Cancer in Ulcerative Colitis: A Scandinavian Population\u2010Based Cohort Study","volume":"395","author":"Ol\u00e9n 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