{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,7]],"date-time":"2026-10-07T11:51:13Z","timestamp":1791373873856,"version":"4.3.1"},"reference-count":54,"publisher":"Wiley","license":[{"start":{"date-parts":[[2026,10,7]],"date-time":"2026-10-07T00:00:00Z","timestamp":1791331200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2026,10,7]],"date-time":"2026-10-07T00:00:00Z","timestamp":1791331200000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Small"],"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>\n                    A multifunctional supramolecular hydrogel (TF\u2010MOD) through the synergistic integration of thioctic acid (TA), Fe\n                    <jats:sup>3+<\/jats:sup>\n                    , and MnO\n                    <jats:sub>2<\/jats:sub>\n                    @dopamine (DA) nanozymes was developed for diabetic wounds. The TA\u2010based dynamic disulfide network offered remarkable injectability, tissue adhesion, and controllable degradation. The Fe\n                    <jats:sup>3+<\/jats:sup>\n                    coordination significantly improved mechanical stability through metal\u2010ligand interactions. The incorporated MnO\n                    <jats:sub>2<\/jats:sub>\n                    @DA nanozymes created a triple therapeutic synergy through cooperative antioxidant effects (MnO\n                    <jats:sub>2<\/jats:sub>\n                    \u2019s catalase\u2010like activity, TA's redox activity achieving 92.3% H\n                    <jats:sub>2<\/jats:sub>\n                    O\n                    <jats:sub>2<\/jats:sub>\n                    clearance), antimicrobial action (photothermal therapy with a 26.1\u00b0C temperature increase and TA's inherent antibacterial properties), and enhanced anti\u2010inflammatory effects combined with pro\u2010angiogenic effects mediated by the nanozymes. Through rheological analysis, lap\u2010shear testing, and injectability assessments, the establishment of a stable yet dynamic network structure exhibited remarkable self\u2010healing, injectability, and tissue adhesion. The TF\u2010MOD hydrogel was designed to promote diabetic wound healing by providing sustained antibacterial efficacy (16.1% residual MRSA biofilm), anti\u2010inflammatory activity, and pro\u2010angiogenic effects, thereby enhancing collagen deposition (68.2%) and reducing wound area (15.2% remaining on day 10) significantly. Additionally, the TF\u2010MOD hydrogel demonstrated dual therapeutic effects for both infected wounds (12.4% residual area, 67.8% collagen deposition) and incisional wounds (214.8\u00a0\u00b5m width). The TF\u2010MOD hydrogel served as a novel and versatile platform for diabetic wound therapy.\n                  <\/jats:p>","DOI":"10.1002\/smll.76086","type":"journal-article","created":{"date-parts":[[2026,10,7]],"date-time":"2026-10-07T11:04:27Z","timestamp":1791371067000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Synergistic Effect of Anti\u2010Infection, Anti\u2010Inflammatory and Pro\u2010Angiogenic for Novel Nanozyme\u2010Reinforced Supramolecular Hydrogel in Diabetic Wound Healing"],"prefix":"10.1002","author":[{"ORCID":"https:\/\/orcid.org\/0009-0000-4038-3243","authenticated-orcid":false,"given":"Ye","family":"Zhang","sequence":"first","affiliation":[{"name":"State Key Laboratory of Food Nutrition and Safety Tianjin University of Science and Technology (TUST)  Tianjin People's Republic of 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Science and Technology Shandong Academy of Agricultural Sciences  Jinan People's Republic of China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wenjie","family":"Wang","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Food Nutrition and Safety Tianjin University of Science and Technology (TUST)  Tianjin People's Republic of China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5939-4700","authenticated-orcid":false,"given":"Tianxin","family":"Wang","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Food Nutrition and Safety Tianjin University of Science and Technology (TUST)  Tianjin People's Republic of China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Biao","family":"Wang","sequence":"additional","affiliation":[{"name":"College of Chemical Engineering and Material Science Tianjin University of Science and Technology  Tianjin People's Republic of 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