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In this study, we established a diabetic rat wound model and found that the diabetic microenvironment significantly impaired angiogenesis, thereby delaying wound healing. To address this, a composite microneedle patch (M\u2010TCHb MN) enabling in situ oxygen release was designed. The M\u2010TCHb MN integrates TA\u2010Ce metal phenol networks\u2010encapsulated Hb nanoparticles (TA\u2010Ce@Hb NPs) encapsulated in silk fibroin (SF) at needle tips with MXene nanosheets encapsulated in PVA at the base layer. In vitro studies confirmed that the base layer inhibits bacterial infection via PTT. TA\u2010Ce@Hb NPs released from needle tips reduced oxidative stress and regulated macrophage polarization for inflammation resolution, while simultaneously catalyzing H\n                    <jats:sub>2<\/jats:sub>\n                    O\n                    <jats:sub>2<\/jats:sub>\n                    decomposition to generate O\n                    <jats:sub>2<\/jats:sub>\n                    . It works synergistically with Hb's oxygen release to reverse a hypoxic environment and promote angiogenesis. In vivo, M+TCHb MN suppressed infection, controlled inflammation, and enhanced angiogenesis. RNA sequencing analysis revealed that the relief of hypoxia enhances angiogenesis (upregulating the expression of VEGF) by activating the MEK1\/2\u2010ERK1\/2 pathway. Collectively, M\u2010TCHb MN represents an integrated strategy that combines antimicrobial, antioxidant, anti\u2010inflammatory, and pro\u2010angiogenic functions to synergistically accelerate diabetic wound healing, offering a translatable platform for clinical management.\n                  <\/jats:p>","DOI":"10.1002\/smll.76180","type":"journal-article","created":{"date-parts":[[2026,10,9]],"date-time":"2026-10-09T12:25:42Z","timestamp":1791548742000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["In Situ Oxygen\u2010Releasing Microneedle Regulates Hypoxic Microenvironment and Promotes Angiogenesis Through MEK1\/2\u2010ERK1\/2 Pathway for Diabetic Infected Wound Healing"],"prefix":"10.1002","author":[{"given":"Xuemin","family":"Ma","sequence":"first","affiliation":[{"name":"Oral &amp; Maxillofacial Reconstruction and Regeneration of Luzhou Key Laboratory The Affiliated Stomatological Hospital Southwest Medical 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