{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,19]],"date-time":"2026-10-19T12:43:55Z","timestamp":1792413835600,"version":"4.4.0"},"reference-count":38,"publisher":"Wiley","license":[{"start":{"date-parts":[[2026,10,19]],"date-time":"2026-10-19T00:00:00Z","timestamp":1792368000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2026,10,19]],"date-time":"2026-10-19T00:00:00Z","timestamp":1792368000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["32271394"],"award-info":[{"award-number":["32271394"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Small"],"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>\n                    Metal oxides are important nanocatalytic materials for small\u2010molecule activation, owing to their variable valence states and efficient charge\u2010transfer capabilities. This activation is governed by coupled oxide\u2013molecule interfacial processes, for which conventional descriptors such as morphology, composition, and defects remain insufficiently precise. Here, we establish crystal facets as descriptors for oxide surface regulation and use laser desorption\/ionization mass spectrometry (LDI\u2010MS) as a high\u2010throughput readout of metabolite activation. Across CeO\n                    <jats:sub>2<\/jats:sub>\n                    , Co\n                    <jats:sub>3<\/jats:sub>\n                    O\n                    <jats:sub>4<\/jats:sub>\n                    , and Cu\n                    <jats:sub>2<\/jats:sub>\n                    O, exposed facets strongly regulate metabolite desorption\/ionization, with the (110) facet consistently exhibiting superior activity. Mechanistic studies and density functional theory calculations reveal that facet exposure modulates surface valence states, oxygen\u2010vacancy formation, charge transfer, carrier dynamics, and energy dissipation. In particular, (110) CeO\n                    <jats:sub>2<\/jats:sub>\n                    integrates favorable defect structures, low work function, efficient charge separation, and localized energy confinement, enabling enhanced metabolite activation with up to three orders of magnitude signal improvement, high reproducibility, and salt\/protein tolerance. The optimized (110) CeO\n                    <jats:sub>2<\/jats:sub>\n                    matrix enables serum metabolic fingerprinting for AI\u2010assisted discrimination of hepatocellular carcinoma from chronic liver disease and biomarker identification. This work demonstrates facet engineering as a strategy for designing oxide nanointerfaces that translate molecular activation into chemically informative fingerprints for disease screening.\n                  <\/jats:p>","DOI":"10.1002\/smll.76193","type":"journal-article","created":{"date-parts":[[2026,10,19]],"date-time":"2026-10-19T12:05:17Z","timestamp":1792411517000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Facet\u2010Programmed Oxide Nanointerfaces for Metabolite Activation and AI\u2010Assisted Disease Screening"],"prefix":"10.1002","author":[{"given":"Shaoxuan","family":"Shui","sequence":"first","affiliation":[{"name":"National Engineering Research Center for Biomaterials College of Biomedical Engineering Sichuan University  Chengdu China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yujia","family":"Jiang","sequence":"additional","affiliation":[{"name":"National Engineering Research Center for Biomaterials College of Biomedical Engineering Sichuan University  Chengdu China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Juan","family":"Zhou","sequence":"additional","affiliation":[{"name":"Department of Laboratory Medicine West China Hospital Sichuan University  Chengdu China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Haoyu","family":"Qiu","sequence":"additional","affiliation":[{"name":"National Engineering Research Center for Biomaterials College of Biomedical Engineering Sichuan University  Chengdu China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jianhua","family":"Lu","sequence":"additional","affiliation":[{"name":"National Engineering Research Center for Biomaterials College of Biomedical Engineering Sichuan University  Chengdu China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fang","family":"Lan","sequence":"additional","affiliation":[{"name":"National Engineering 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