{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,11]],"date-time":"2026-10-11T16:46:09Z","timestamp":1791737169733,"version":"4.3.4"},"reference-count":41,"publisher":"Wiley","license":[{"start":{"date-parts":[[2026,10,11]],"date-time":"2026-10-11T00:00:00Z","timestamp":1791676800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2026,10,11]],"date-time":"2026-10-11T00:00:00Z","timestamp":1791676800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/501100003787","name":"Natural Science Foundation of Hebei Province","doi-asserted-by":"publisher","award":["B2026202010"],"award-info":[{"award-number":["B2026202010"]}],"id":[{"id":"10.13039\/501100003787","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Small"],"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>\n                    Essential micronutrient Vitamin B\n                    <jats:sub>2<\/jats:sub>\n                    (VB\n                    <jats:sub>2<\/jats:sub>\n                    ) is a bioactive compound with sonodynamic activity; however, it suffers from hydrophilic limitations. Herein, a dynamic prodrug nanocomplex (PTX\u2010PBA\/VB\n                    <jats:sub>2<\/jats:sub>\n                    ) was constructed via phenylboronic acid\u2010diol interaction between VB\n                    <jats:sub>2<\/jats:sub>\n                    and phenylboronic acid\u2010functionalized paclitaxel prodrug (PTX\u2010PBA). This reversible boronate ester linkage ensures colloidal stability while enabling external stimuli\u2010 or tumor microenvironment\u2010triggered drug release. Under ultrasound irradiation, the nanocomplex generates singlet oxygen (\n                    <jats:sup>1<\/jats:sup>\n                    O\n                    <jats:sub>2<\/jats:sub>\n                    ) and hydroxyl radical, inducing prodrug cleavage, on\u2010demand paclitaxel release, glutathione depletion, and glutathione peroxidase 4 downregulation, leading to amplified oxidative stress and immunogenic cell death. Prolonged intratumoral retention (&gt;7 days) was realized by loading PTX\u2010PBA\/VB\n                    <jats:sub>2<\/jats:sub>\n                    nanocomplex into an injectable poly(amino acid) hydrogel. In vivo study presented remarkable tumor suppression in 4T1\u2010bearing mice, attributed to enhanced intratumoral reactive oxygen species levels and lipid peroxidation accompanied by robust immune activation. This work establishes a promising dynamic covalent prodrug strategy for precise sonoimmunotherapy.\n                  <\/jats:p>","DOI":"10.1002\/smll.76195","type":"journal-article","created":{"date-parts":[[2026,10,11]],"date-time":"2026-10-11T15:56:26Z","timestamp":1791734186000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Dynamic Covalent Prodrug Nanocomplex for Ultrasound\u2010Triggered Oxidative Stress Amplification and Synergistic Sonochemotherapy"],"prefix":"10.1002","author":[{"given":"Hancheng","family":"Jiang","sequence":"first","affiliation":[{"name":"Institute of Polymer Science and Engineering School of Chemical Engineering Hebei University of Technology  Tianjin People's Republic of China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jianxin","family":"Rong","sequence":"additional","affiliation":[{"name":"Institute of Polymer Science and Engineering School of Chemical Engineering Hebei University of Technology  Tianjin People's Republic of China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yu","family":"Guo","sequence":"additional","affiliation":[{"name":"Institute of Polymer Science and Engineering School of Chemical Engineering Hebei University of Technology  Tianjin People's Republic of China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yingjian","family":"Cui","sequence":"additional","affiliation":[{"name":"Institute of Polymer Science and Engineering School of Chemical Engineering Hebei University of Technology  Tianjin People's Republic of China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaoya","family":"Wu","sequence":"additional","affiliation":[{"name":"Institute of Polymer Science and Engineering School of Chemical Engineering Hebei University of Technology  Tianjin People's Republic of 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