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To address this challenge, we developed carrier\u2010free Cur\/DTX@ICG nanoparticles via molecular co\u2010assembly, achieving a high drug\u2010loading capacity of 66.7%. This theranostic platform integrates docetaxel, curcumin, and indocyanine green for chemotherapy, anti\u2010inflammatory chemosensitization, and fluorescence imaging. Cur\/DTX@ICG effectively inhibited triple\u2010negative breast cancer (TNBC) cell proliferation and migration in vitro. In vivo, it suppressed subcutaneous tumor growth by 74.5% and achieved 77.1% inhibition of postoperative lung metastasis while prolonging survival. Mechanistically, Cur\/DTX@ICG attenuated chemotherapy\u2010associated inflammatory responses by reducing serum TNF\u2010\u03b1, IL\u20106, and IL\u20101\u03b2 levels, suppressing nuclear factor\u2010\u03baB (NF\u2010\u03baB) activation, and partially reversing epithelial\u2013mesenchymal transition (EMT) progression. These findings suggest that Cur\/DTX@ICG represents a promising carrier\u2010free strategy for suppressing inflammation\u2010associated metastatic progression in TNBC.<\/jats:p>","DOI":"10.1002\/smll.76217","type":"journal-article","created":{"date-parts":[[2026,10,13]],"date-time":"2026-10-13T08:50:12Z","timestamp":1791881412000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Carrier\u2010Free Cur\/DTX@ICG Ternary Nanoparticles for Suppressing Lung Metastasis in Triple\u2010Negative Breast Cancer"],"prefix":"10.1002","author":[{"given":"Shupeng","family":"Han","sequence":"first","affiliation":[{"name":"Department of Breast Surgery The First Affiliated Hospital of Xi'an Jiaotong University  Xi'an Shaanxi China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Meichen","family":"Zheng","sequence":"additional","affiliation":[{"name":"School of Public Health Health Science Center Xi'an Jiaotong 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