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The capabilities of tumor cells for rapid proliferation, resistance to death, and metastasis have become major hurdles in the successful treatment of cancer. Nanomotors, with distinct advantages such as tumor targeting and excellent biocompatibility, have emerged as a crucial research area in cancer therapy. This type of nanoscale dynamic system can convert external energy sources like magnetic fields, light fields, and sound fields, as well as endogenous chemical energy such as hydrogen peroxide, into autonomously driven mechanical energy. These distinctive motion characteristics remarkably enhance the penetration efficiency of nanocarriers into tumor tissue. This offers a promising approach to overcome the physiological barriers of the tumor microenvironment and improve therapeutic efficacy. In this review, the latest advancements in tumor treatment using nanomotors are systematically summarized. 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