{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,18]],"date-time":"2026-10-18T20:41:31Z","timestamp":1792356091088,"version":"4.4.0"},"reference-count":73,"publisher":"Wiley","license":[{"start":{"date-parts":[[2026,10,18]],"date-time":"2026-10-18T00:00:00Z","timestamp":1792281600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,10,18]],"date-time":"2026-10-18T00:00:00Z","timestamp":1792281600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/501100001164","name":"Australian Synchrotron","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100001164","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Small"],"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>\n                    Bio\u2010aerogels are a class of ultra\u2010lightweight, extremely porous, solid materials that are engineered from biopolymers, e.g., polysaccharides, proteins, or peptides. Such biomaterials are of interest for medical and environmental applications, such as molecular filtration, wound healing, or tissue engineering. In this context, ultrashort peptides, defined as sequences of up to ten amino acids, are attractive self\u2010assembling building blocks for bio\u2010aerogels, due to their low\u2010cost synthesis, chemical tunability, and potential biocompatibility. Building on our previous report demonstrating the intrinsic self\u2010assembly of the human tachykinin Substance P into semi\u2010flexible nanotubes, we focus on the tachykinin consensus sequence FFGLM\u2010NH\n                    <jats:sub>2<\/jats:sub>\n                    , proposed here as the core motif driving native tachykinin self\u2010assembly. Named tachycontide\u20101, the consensus pentapeptide can self\u2010assemble into hydrogels and alcogels, a rare property for short peptides. As a result, the peptide aerogels can be fabricated by direct supercritical drying of a one\u2010pot reaction mixture in ethanol. Using a set of biophysical techniques, including fluorescence spectroscopy, infrared spectroscopy, rheology, optical\/electron microscopy, synchrotron small\/wide\u2010angle X\u2010ray scattering, nitrogen adsorption\u2010desorption analysis, and atomistic simulations, we examine the solvent influence on peptide self\u2010assembly and its impact on the resulting aerogel structure, crystallinity, and physical properties.\n                  <\/jats:p>","DOI":"10.1002\/smll.76351","type":"journal-article","created":{"date-parts":[[2026,10,18]],"date-time":"2026-10-18T20:35:11Z","timestamp":1792355711000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["One\u2010Pot Fabrication of Pentapeptide Bio\u2010Aerogel via Direct Alcogelation"],"prefix":"10.1002","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-6157-7119","authenticated-orcid":false,"given":"Brody","family":"McDonald","sequence":"first","affiliation":[{"name":"School of Health and Biomedical Sciences RMIT University  Melbourne Victoria Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4547-4712","authenticated-orcid":false,"given":"Durga","family":"Dharmadana","sequence":"additional","affiliation":[{"name":"School of Health and Biomedical Sciences RMIT University  Melbourne Victoria Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6358-2974","authenticated-orcid":false,"given":"Nevena","family":"Todorova","sequence":"additional","affiliation":[{"name":"School of Engineering RMIT University  Melbourne Victoria Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Boyin","family":"Liu","sequence":"additional","affiliation":[{"name":"Bioimaging Platform La Trobe University  Melbourne Victoria Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shuaiyu","family":"Jiang","sequence":"additional","affiliation":[{"name":"School of Science RMIT University  Melbourne Victoria Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0781-4926","authenticated-orcid":false,"given":"Ewan W.","family":"Blanch","sequence":"additional","affiliation":[{"name":"School of Science RMIT University  Melbourne Victoria Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4724-3651","authenticated-orcid":false,"given":"C\u00e9line","family":"Val\u00e9ry","sequence":"additional","affiliation":[{"name":"School of Health and Biomedical Sciences RMIT University  Melbourne Victoria Australia"},{"name":"School of Health Sciences Faculty of Medicine and Health UNSW Sydney  Sydney New South Wales Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,10,18]]},"reference":[{"key":"e_1_2_10_2_1","first-page":"1","volume-title":"Springer Handbook of Aerogels","author":"Steiner S. 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