{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,8]],"date-time":"2026-10-08T15:41:31Z","timestamp":1791474091557,"version":"4.3.4"},"reference-count":36,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2025,2,26]],"date-time":"2025-02-26T00:00:00Z","timestamp":1740528000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Smart Medicine"],"published-print":{"date-parts":[[2025,3]]},"abstract":"<jats:title>ABSTRACT<\/jats:title><jats:p>Allergic contact dermatitis (ACD) is an inflammatory dermatitis with a high morbidity and recurrence rate. Scientific attention is focused on the development of safe and comfortable therapeutics of ACD. Herein, we propose a natural matrine\u2010integrated pollen delivery system for the ACD treatment. Sunflower pollens were collected and defatted to serve as adhesive drug carriers for matrine. Specifically, the exquisite porous and hollow structures of the pollen shells can absorb matrine and realize the sustained drug release. Besides, the prickly surface morphology can strongly adhere to the inflamed skin sites, which can prolong the duration of the drug. By utilizing them in an ACD model and an acute pruritus model of mice, we have demonstrated that these matrine\u2010integrated pollen shells can decrease the swelling degree of mice ears and weight loss, down\u2010regulate inflammatory response, and improve the scratching times. These results indicate that our matrine\u2010integrated pollen delivery systems have great potential to serve as natural topical preparations for skin disease therapy.<\/jats:p>","DOI":"10.1002\/smmd.136","type":"journal-article","created":{"date-parts":[[2025,2,27]],"date-time":"2025-02-27T00:41:16Z","timestamp":1740616876000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":22,"title":["Natural Matrine\u2010Integrated Pollen Delivery Systems for Allergic Contact Dermatitis Treatment"],"prefix":"10.1002","volume":"4","author":[{"ORCID":"https:\/\/orcid.org\/0009-0003-0414-4490","authenticated-orcid":false,"given":"Yuwei","family":"Wang","sequence":"first","affiliation":[{"name":"Department of Rheumatology and Immunology Nanjing Drum Tower Hospital Clinical Medical College of Traditional Chinese and Western Medicine Nanjing University of Chinese Medicine  Nanjing China"},{"name":"Department of Rheumatology and Immunology Lianyungang Affiliated Hospital of Nanjing University of Chinese Medicine  Lianyungang China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lijun","family":"Cai","sequence":"additional","affiliation":[{"name":"School of Biological Science and Medical Engineering Southeast University  Nanjing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuanyuan","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of Dermatology and Venereology Nanjing Drum Tower Hospital Affiliated Hospital of Medical School Nanjing University  Nanjing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yan","family":"Cong","sequence":"additional","affiliation":[{"name":"Department of Rheumatology and Immunology Lianyungang Affiliated Hospital of Nanjing University of Chinese Medicine  Lianyungang 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