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Biotechnologies and biomedical engineering technologies provide new hope for the treatment of auditory diseases, which utilizes biological strategies or tissue engineering methods to achieve drug delivery and the regeneration of cells, tissues, and even organs. Here, the advancements in the applications of biotechnologies (including gene therapy and cochlear organoids) and biomedical engineering technologies (including drug delivery, electrode coating, electrical stimulation and bionic scaffolds) in the field of hearing reconstruction are presented. Moreover, we summarize the challenges and provide a perspective on this field.<\/jats:p>","DOI":"10.1002\/smmd.20230021","type":"journal-article","created":{"date-parts":[[2023,10,27]],"date-time":"2023-10-27T17:19:19Z","timestamp":1698427159000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":8,"title":["Emerging biotechnologies and biomedical engineering technologies for hearing reconstruction"],"prefix":"10.1002","volume":"2","author":[{"given":"Yangnan","family":"Hu","sequence":"first","affiliation":[{"name":"State Key Laboratory of Digital Medical Engineering Department of Otolaryngology Head and Neck Surgery Zhongda Hospital School of Life Sciences and Technology Advanced Institute for Life and Health Jiangsu Province High\u2010Tech Key Laboratory for Bio\u2010Medical Research Southeast University  Nanjing China"},{"name":"Co\u2010Innovation Center of Neuroregeneration Nantong University  Nantong 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