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Current research focuses on developing advanced decellularized scaffolds and designing multifunctional structures to enhance tissue repair. In this study, a kind of polydopamine (PDA)\u2010integrated decellularized porcine small intestine tissue (dSI) and alginate (ALG) composite hydrogel microparticles (PDA@dSI\/ALG) are proposed for efficient wound healing. These PDA@dSI\/ALG are prepared via microfluidic electrospray technology combined with ionic crosslinking, followed by PDA coating. The dSI is derived from porcine small intestine tissue and is rich in various nutrients, which can promote the repair of damaged tissues. Moreover, incorporating PDA imparts the microparticles with superior photothermal responsiveness under near\u2010infrared irradiation, enabling efficient heat generation to eradicate bacteria. 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