{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,30]],"date-time":"2026-09-30T00:18:40Z","timestamp":1790727520980,"version":"4.1.0"},"reference-count":37,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2026,3,19]],"date-time":"2026-03-19T00:00:00Z","timestamp":1773878400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,3,19]],"date-time":"2026-03-19T00:00:00Z","timestamp":1773878400000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Smart Medicine"],"published-print":{"date-parts":[[2026,4]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>Neuroinflammation is a core pathological mechanism in neurodegenerative diseases. Although natural many compounds, derived from traditional Chinese medicine have shown promise in modulating neuroinflammation, conventional evaluation methods remain inefficient and fail to meet modern drug development needs. This study aimed to develop a neuroinflammation\u2010on\u2010a\u2010chip for efficient and accurate evaluation of the anti\u2010neuroinflammatory activity of such compounds. By integrating gelatin methacryloyl (GelMA) hydrogel with a microchamber array structure into a multi\u2010channel concentration\u2010gradient microfluidic chip, we constructed a functional neuroinflammation\u2010on\u2010a\u2010chip suitable for high\u2010throughput drug screening. Preliminary results demonstrated that the chip can successfully model lipopolysaccharide (LPS)\u2010induced neuroinflammation and test the anti\u2010inflammatory effects of curcumin (Cur) and resveratrol (RSV). Relative to traditional approaches, the chip offers the advantages of low sample consumption, rapid detection, and high data reliability. This study provides a novel tool for the efficient evaluation of anti\u2010neuroinflammatory activity of traditional Chinese medicine active compounds and offers an innovative platform for research on neuroinflammation\u2010related diseases.<\/jats:p>","DOI":"10.1002\/smmd.70032","type":"journal-article","created":{"date-parts":[[2026,3,19]],"date-time":"2026-03-19T09:34:16Z","timestamp":1773912856000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Constructing Neuroinflammation\u2010On\u2010A\u2010Chip for Traditional Chinese Medicine Extracts Evaluation"],"prefix":"10.1002","volume":"5","author":[{"given":"Xirui","family":"Wang","sequence":"first","affiliation":[{"name":"School of Clinical Pharmacy Shenyang Pharmaceutical University  Shenyang China"},{"name":"Academy of Military Medical Sciences  Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiang","family":"Lin","sequence":"additional","affiliation":[{"name":"Pharmaceutical Sciences Laboratory \u00c5bo Akademi University  Turku Finland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yue","family":"Zhi","sequence":"additional","affiliation":[{"name":"School of Medicine Southeast University  Nanjing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7458-9100","authenticated-orcid":false,"given":"Luoran","family":"Shang","sequence":"additional","affiliation":[{"name":"Institutes of Biomedical Sciences Fudan University  Shanghai China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuan","family":"Luo","sequence":"additional","affiliation":[{"name":"Academy of Military Medical Sciences  Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yongan","family":"Wang","sequence":"additional","affiliation":[{"name":"School of Clinical Pharmacy Shenyang Pharmaceutical University  Shenyang China"},{"name":"Academy of Military Medical Sciences  Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,3,19]]},"reference":[{"key":"e_1_2_10_2_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41392-023-01588-0"},{"key":"e_1_2_10_3_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41392-025-02179-x"},{"key":"e_1_2_10_4_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41577-024-01104-7"},{"key":"e_1_2_10_5_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.add1236"},{"key":"e_1_2_10_6_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41586-020-2681-2"},{"key":"e_1_2_10_7_1","doi-asserted-by":"publisher","DOI":"10.1002\/alz.091295"},{"key":"e_1_2_10_8_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41531-024-00640-2"},{"issue":"1","key":"e_1_2_10_9_1","article-title":"Enrichment of Somatic Cancer Driver Mutations in Alzheimer\u2019s Disease Microglia and Its Association With Neuroinflammation","volume":"20","author":"Huang A. 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